AN EVALUATION OF THE EFFECT OF USING SELECTIVE SERATONIN RE-UPTAKE INHIBITORS ON PERIOPERATIVE BLEEDING IN GYNECOLOGY PATIENTS

Abstract

Aim:The aim of this study was to examine the effects of the use of SSRI by patients in different gynecological operations, through an evaluation of operation type, bleeding amount, requirement for blood and amount of blood transfused. Material and Methods: A retrospective evaluation was made of patients who underwent gynecological surgery. Patients who were taking and not taking SSRI were compared in respect of preoperative and postoperative hemoglobin, hematocrit, platelet count, activated partial thromboplastin time (APTT), INR values, requirement for blood transfusion, and amount of blood transfused. Results: The use of antidepressant drugs by gynaecology patients was not seen to increase bleeding and caused no decrease in hemoglobin or hematocrit values. No statistically significant difference was determined between the groups in respect of the requirement and amount of blood transfusions. Conclusion: There is no need to terminate the use of SSRI because of potential bleeding effects or to evaluate patients in respect of these effects. It can be considered sufficient to monitor these patients closely perioperatively and to carefully follow the bleeding protocol.

Keywords

• selective seratonin re-uptake inhibitors
• intraoperative bleeding
• gynecologic operations
• blood transfusion

JİNEKOLOJİ HASTALARINDA SELEKTİF SERATONİN GERİ ALIM İNHİBİTÖRLERİ KULLANMANIN KANAMA ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ

Abstract

Amaç: Çalışmanın amacı SSRİ kullanan ve değişik jinekolojik operasyonlar geçien hastalarda operasyon tipi, kanama miktarı, kan transfüzyon ihtiyacı ve transfüzyon yapılan kan miktarını değerlendirmektir. Gereç ve yöntem: Jinekolojik operasyon geçiren hastalarda retrospektif değerlendirme yapıldı. SSRİ kullanan ve kullanmayan hastalar peroperatif ve postoperatif hemoglobin, hematokrit, trombosit sayısı, aktive parsiyel tromboplastin zamanı (APTT), INR değeri; kan transfüzyonu ihtiyacı ve transfüze edilen kan miktarı açısından karşılaştırıldı. Bulgular: Jinekolojik operasyon geçiren hastalarda SSRİ grubundan antidepresan ilaçların kanamada artmaya ve hemoglobin ve hematokrit değerlerinde düşmeye neden olmadığı görüldü. Gruplar arasında kan transfüzyonu ihtiyacı ve miktarı açısından istatistiksel olarak anlamlı fark bulunamadı. Sonuç: Potansiyel kanama etkisi yüzünden SSRİ'lerinin preoperatif dönemde kullanımının kesilmesine gerek yoktur. Bu hastaları perioperatif dönemde yakın takip edilmesi ve kanama protokolünün dikkatli izlenmesi yeterlidir.

Keywords

• selektif seratonin geri alım inhibitörleri
• intraoperatif kanama
• jinekolojik orerasyonlar
• kan transfüzyonu

References

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