Premenapozal dönemde eksize edilen endometrial poliplerin farklı vücut kitle indekslerine göre histopatolojik sonuçlarının karşılaştırılması

Abstract

Amaç: Premenapozal dönemde eksize edilen semptomatik endometrial poliplerin histopatolojik özelliklerini farklı vücut kitle indeksine sahip kadınlarda karşılaştırmak ve obezite varlığının poliplerin premalign/malign dejenerasyonu için bir risk faktörü olup olamayacağını araştırmak Yöntem: Anormal uterin kanama nedeniyle başvuran ve endometrial polip ön tansıyla operatif histereskopi uygulanan premenapozal dönemdeki kadınların histopatolojik sonuçları retrospektif olarak incelenmiştir. Sonuçları; benign (polip), premalign (hiperplastik polip±nükleer atipi), malign (polip zemininde gelişmiş karsinom) olarak kaydedilmiştir. Bulgular: Altıyüz onsekiz kadının 23 (%3.7) tanesinde premalign lezyon tespit edilirken, hiçbir olguda malignite izlenmemiştir. Premalign bulguların olduğu gruptaki obezite sıklığı benign bulgular tespit edilen gruba göre anlamlı derecede daha fazla idi. Regresyon analizi sonucunda obezite varlığı premalign endometrial polip ihtimalini normal kilolulara göre yaklaşık 4.5 kat arttırmaktaydı. Sonuç: Premenapozal dönemde anormal uterin kanama etyolojisinde tespit edilen endometrial poliplerin premalign/malign olma ihtimali oldukça düşüktür. Ancak, obezite varlığında bu ihtimalin gerçekleşmesi anlamlı derecede artmaktadır.

Keywords

• endometrial polip
• premenapoz dönem
• histopatoloji
• vücut kitle indeksi

Comparison of Histopathological Findings of Endometrial Polyps Excised in The Premenopausal Period According to Different Body Mass Indexes

Abstract

Objective: To compare the histopathological features of symptomatic endometrial polyps excised in the premenopausal period in women with different body mass index and to investigate whether the presence of obesity may be a risk factor for premalignant / malignant degeneration of polyps. Methods: The histopathological findings of premenopausal women who applied for abnormal uterine bleeding and underwent operative hysteroscopy for endometrial polyps were retrospectively analyzed. Findings were recorded as benign (polyp), premalignant (hyperplastic polyp ± nuclear atypia), malignant (carcinoma developed on the basis of polyp). Results: While premalignant lesions were detected in 23 (3.7%) of six hundred and eighteen women, malignancy was not observed in any of the cases. The frequency of obesity in the group with premalignant findings was significantly higher than the group with benign findings. As a result of the regression analysis, the presence of obesity increased the probability of premalignant endometrial polyp approximately 4.5 times compared to normal weight individuals. Conclusion: Endometrial polyps detected in the etiology of abnormal uterine bleeding in the premenopausal period are unlikely to be premalignant / malignant. However, the realization of this possibility increases significantly in the presence of obesity.

Keywords

• endometrial polyp
• premenopausal period
• histopathology
• body mass index

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