Is there a relationship between bone mineral density and platelet indices?

Abstract

Aim: To investigate whether there is a relationship between bone mineral density measurements and thrombocyte indices. Material and Methods: Bone mineral density measurements and thrombocyte indices of postmenopausal women with and without osteoporosis were recorded retrospectively. Platelet count, mean thrombocyte volume and platelet distribution width values were noted as platelet indices. Results: The mean platelet volume and platelet distribution width were significantly higher in patients with osteoporosis than those without. There was a negative correlation between these two platelet indices values and lumbar 1-4 vertebra and femur total bone mineral density values. Conclusion: There is a significant relationship between bone mineral density values and mean platelet volume and platelet distribution width values. This suggests that bone metabolism and platelet metabolism are related.

Keywords

• bone mineral density
• osteoporosis
• platelets

Kemik mineral yoğunluğu ile trombosit endeksleri arasında ilişki var mıdır?

Abstract

Amaç: Kemik mineral yoğunluğu ölçümleri ile trombosit endeksleri arasında bir ilişki olup olmadığını araştırmak Gereç ve Yöntemler: Postmenapozal kadınlar arasından osteoporoz olan ve olmayanların kemik mineral yoğunluk ölçümleri ve ölçüm günü bakılan trombosit endeksleri retrospektif olarak kaydedildi. Trombosit endeksleri olarak trombosit sayısı, ortalama tombosit hacmi ve trombosit dağılım genişliği değerleri not edildi. Bulgular: Osteoporoz olanlarda ortalama trombosit hacmi ve trombosit dağılım genişliği olmayanlara göre anlamlı derecede daha fazlaydı. Bu iki trombosit endeks değerleri ile lumbar 1-4 vertebra ve Femur total kemik mineral yoğunluğu değerleri arasında negatif yönde ilişki mevcuttu. Sonuç: Kemik mineral yoğunluğu değerleri ile ortalama trombosit hacmi ve trombosit dağılım genişliği değerleri anlamlı ilişki mevcuttur. Bu durum kemik metabolizması ile trombosit metabolizmasının bağlantılı olduğunu düşündürmektedir.

Keywords

• kemik mineral yoğunluğu
• osteoporoz
• trombosit

References

1. 1- Armas LA, Recker RR. Pathophysiology of osteoporosis: new mechanistic insights. Endocrinol Metab Clin North Am. 2012 Sep;41(3):475-86
2. 2- Compston JE, McClung MR, Leslie WD. Osteoporosis. Lancet. 2019;393(10169):364-76
3. 3- Li S, Guo H, Liu Y, Wu F, Zhang H, Zhang Z, et al. Relationships of serum lipid profiles and bone mineral density in postmenopausal Chinese women. Clin Endocrinol (Oxf). 2015;82(1):53-8
4. 4- Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and metaanalysis. J Thromb Haemost 2010;8(1):148-56
5. 5- Yang TL, Shen H, Liu A, Dong SS, Zhang L, Deng FY, et al. A road map for understanding molecular and genetic determinants of osteoporosis. Nat Rev Endocrinol. 2020 Feb;16(2):91-103
6. 6- Marino M, Scuderi F, Ponte E, Maiuri MT, De Cristofaro R, Provenzano C, et al. Novel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets. J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):841-52
7. 7- Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, et al. Executive summary of the Stages of Reproductive Aging Workshop +10: Addressing the unfinished agenda of staging reproductive aging. Fertil Steril. 2012;97:843-5
8. 8- WHO. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis Report of a WHO Study Group. Geneva WHO, 1994, World Health Organ Tech Rep Ser 1994;843:1-129

9. 9-Li X-s, Zhang JR, Meng SY, Li Y, Wang RT. Mean platelet volume is negatively associated with bone mineral density in postmenopausal women. J Bone Miner Metab 2012;30:660-5
10. 10-Akbal A, Gökmen F, Gencer M, İnceer B, Kömürcü E. Mean platelet volume and platelet distribution width can be related to bone mineralization. Osteoporos Int 2014;25:2291-5
11. 11-Aypak C, Türedi Ö, Bircan MA, Civelek GM, Araz M. Association between mean platelet volume and bone mineral density in postmenopausal women. J Phys Ther Sci 2016;28:1753-8
12. 12-Vural M, Mert M, Erhan B, Gunduz B, Keles BY, Erdem AE, et al. Is there any relationship between mean platelet volume, bone mineral density and vitamin d in postmenopausal women? Acta Med. Mediterr. 2017; 33: 443
13. 13- Salamanna F, Maglio M, Sartori M, Tschon M, Fini M. Platelet Features and Derivatives in Osteoporosis: A Rational and Systematic Review on the Best Evidence. Int J Mol Sci. 2020 Mar 4;21(5):1762
14. 14- Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis. Circ Res. 2018 Jan 19;122(2):337-51
15. 15- Assinger A, Schrottmaier WC, Salzmann M, Rayes J. Platelets in Sepsis: An Update on Experimental Models and Clinical Data. Front Immunol. 2019 Jul 17;10:1687
16. 16-Signorello MG, Giacobbe E, Segantin A, Avigliano L, Sinigaglia F, Maccarrone M, et al. - Activation of human platelets by 2-arachidonoylglycerol: role of PKC in NO/cGMP pathway modulation. Curr Neurovasc Res. 2011 Aug 1;8(3):200-9
17. 17- Giles H, Smith RE, Martin JF. Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction. Eur J Clin Invest 1994;24(1):69-72
18. 18-Bath P, Algert C, Chapman N, Neal B. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease. Stroke 2004;35(3):622-6
19. 19-Cil H, Yavuz C, Islamoglu Y, Tekbas EO, Demirtas S, Atilgan ZA et al. Platelet count and mean platelet volume in patients with in-hospital deep venous thrombosis. Clin Appl Thromb Hemost 2012;18(6):650-3
20. 20-Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events?. Stroke 2004;35(7):1688-91
21. 21- Varol E, Akpinar A. Relationship between mean platelet volume and major depression. J Clin Psychopharmacol. 2013 Oct;33(5):723