Premature Rupture of Membranes: How Does It Affect Neonatal Outcomes in Premature Infants?

Abstract

Aim: Premature rupture of membranes (PROM) can cause preterm birth, neonatal morbidity and mortality. In this study, we aim to examine the effect of PROM on the early prognosis of premature infants <30 weeks, provide a basis for the management of premature infants and prenatal consultation. Materials and Method:710 premature infants with a gestational age of 240-296 weeks who were followed up in a tertiary neonatal intensive care unit between 2014-2018 were retrospectively evaluated. According to the presence of PROM, infants were divided into two groups: PROM group (n = 147) and no-PROM group (n = 563). Maternal and neonatal data were analyzed. Results:In the study, the median (min-max) gestational age (GA) was 27 weeks (24-29) in PROM group, and 28 weeks (25-29) in no-PROM group (p <0.001).The median (min-max) PROM duration was 115 (18-850) hours. Histological chorioamnionitis, the number of babies <28 weeks and early neonatal sepsis were higher in PROM group compared to no-PROM group (p<0.001). Conclusion: PROM may cause poor fetal and neonatal outcomes by increasing the risk of chorioamnionitis and preterm labor. It has been thought that with appropriate follow-up and treatment of pregnant women with PROM in terms of the development of chorioamnionitis, preterm birth and development of neonatal infection might be prevented.

Keywords

• Preterm premature rupture of membranes
• prematurite
• prognosis

Project Number

yok

Erken Membran Rüptürü: Prematüre Bebeklerde Neonatal Sonuçları Nasıl Etkiler?

Abstract

Amaç: Erken membran rüptürü (EMR) preterm doğuma, neonatal morbiditelere ve mortaliteye sebep olabilir. Bu çalışmadaki amacımız EMR’nin <30 hafta prematüre bebeklerin erken prognozu üzerindeki etkisini incelemek, prematüre bebeklerin yönetimi ve prenatal konsültasyon için bir temel sağlamaktır. Gereçler ve Yöntem: 2014-2018 yıllarında, gebelik yaşı 240-296 hafta arasında olan ve üçüncü düzey bir yenidoğan yoğun bakım ünitesinde izlenen toplam 710 prematüre bebek retrospektif olarak değerlendirildi. Hastalar EMR varlığına veya yokluğuna göre EMR grubu (n = 147) ve EMR olmayan grup (n =563) olarak iki gruba ayrıldı. Maternal ve neonatal veriler analiz edildi. Bulgular: Çalışmaya dahil edilen bebeklerden EMR olan grupta median (min-maks) gebelik haftası (GH) 27 hafta (24-29), EMR olmayan grupta 28 hafta (25-29) (p<0.001) idi. EMR süresinin median değeri (min-maks) 115 saat (18-850) olarak saptandı. EMR olmayan grupla karşılaştırıldığında, EMR olan grupta histolojik koryoamniyonit, <28 hafta olan bebek sayısı ve erken neonatal sepsis daha yüksek oranda tespit edildi (p<0.001). Sonuç: EMR, koryoamniyonit ve preterm doğum riskini arttırarak kötü fetal-neonatal sonuçlara sebep olabilir. EMR’li gebelere koryoamniyonit gelişimi açısından uygulanacak uygun takip ve tedavi ile preterm doğum ve neonatal enfeksiyon gelişiminin önlenebileceği düşünüldü.

Keywords

• Erken membran rüptürü
• prematürite
• prognoz

Supporting Institution

yok

Project Number

yok

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