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A Crosssectional Study Of 25 Hydroxy Vitamin D And Parathroid Hormone Status During Pregnancy In Ankara Turkey

Year 2019, Volume: 16 Issue: 3, 152 - 154, 01.07.2019
https://doi.org/10.4274/jcrpe.4706

Abstract

Aim: Vitamin D deficiency is common during pregnancy. We aimed to assess the incidence of vitamin D deficiency and vitamin supplementation rates during pregnancy in a relatively large cohort of pregnant Turkish women.Material and Methods: Pregnant women who admitted to the antenatal follow-up clinic between June and December 2013 fulfilled a survey which includes information about eating habits, lifestyleand vitamin supplementation. Blood samples were obtained to measure vitamin D and Parathyroid hormone levels from the pregnant who gave a written consent.Results: A total of 1088 pregnant women were analyzed. Mean vitamin D concentration was 17.5±9.9 ng/mL and PTH was 18.7±11.4 pg/ ml. Vitamin D deficiency < 20 ng/ml was observed in 693 63.6 % women. Five 0.45% women received vitamin D supplementation alone, 71 6.5 % received multivitamins. Multi-nominal logistic regression analysis revealed that, summer season OR: 92.7, 95% CI 36.4-236; p

References

  • Holick MF. Vitamin D: evolutionary, physiological and health perspecti- ves. Curr Drug Targets2011; 12: 4-18.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96:1911–30.
  • Xiao JP, Zang J, Pei JJ, Xu F, Zhu Y, Liao XP. Low maternal vitamin D sta- tus during the second trimester of pregnancy: a cross-sectional study in Wuxi, China. PLoS One 2015 6;10(2):e0117748.
  • Gür EB, Turan GA, Tatar S, Gökduman A, Karadeniz M, Celik G, et al. Theeffect of place of residenceandlifestyle on vitamin D deficiency in pregnancy: Comparison of easternand western parts of Turkey. J Turk GerGynecolAssoc 2014;15:149-55.
  • Gür G, Abaci A, Köksoy AY, Anik A, Catli G, Kişlal FM, et al. Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a prelimi- narystudy. Turk J Med Sci 2014; 44: 616-23.
  • https://www.saglik.gov.tr/TR,11158/gebelere-d-vitamini-destek-progra- mi.html
  • Marshall I, Mehta R, Petrova A. Vitamin D in the maternal–fetal–neonatal interface: Clinical implications and requirements for supplementation. J Matern Fetal Neonatal Med 2013;26:633–8
  • Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011;26:2341–57
  • Song SJ, Zhou L, Si S, et al. The high prevalence of vitamin D deficiency and its related maternal factors in pregnant women in Beijing. PLoS One 2013;8: e85081.
  • Shibata M, Suzuki A, Sekiya T, et al. High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab 2011;29:615–20
  • Milman N, Hvas AM, Bergholt T. Vitamin D status during normal preg- nancy and postpartum. A longitudinal study in 141 Danish women. J Perinat Med 2011;40:57–61 .
  • Özdemir AA, Ercan Gündemir Y, Küçük M, Yıldıran Sarıcı D, Elgörmüş Y, Çağ Y, Bilek G.Vitamin D Deficiency in Pregnant Women and Their Infants.J Clin Res Pediatr Endocrinol 2018 Mar 1;10(1):44-50. doi: 10.4274/jcrpe.4706
  • Kılıcaslan AÖ, Kutlu R, Kilinc I, Ozberk DI.The effects of vitamin D supp- lementation during pregnancy and maternal vitamin D levels on neonatal vitamin D levels and birth parameters.J Matern Fetal Neonatal Med 2018 Jul;31(13):1727-1734
  • Gür G, Abaci A, Köksoy AY, Anik A, Catli G, Kişlal FM, Akin KO, Andiran N.Incidence of maternal vitamin D deficiency in a region of Ankara, Tur- key: a preliminary study.Turk J Med Sci 2014;44(4):616-23.
  • Aydogmus S, Kelekci S, Aydogmus H, Eriş S, Desdicioğlu R, Yilmaz B, Sağlam G.High prevalence of vitamin D deficiency among pregnant wo- men in a Turkish population and impact on perinatal outcomes.J Matern Fetal Neonatal Med 2015;28(15):1828-32
  • Parlak M, Kalay S, Kalay Z, Kirecci A, Guney O, Koklu E.Severe vitamin D deficiency among pregnant women and their newborns in Turkey.J Matern Fetal Neonatal Med 2015 Mar;28(5):548-51
  • van der Pligt P, Willcox J, Szymlek-Gay EA, Murray E, Worsley A, Daly RM.Associations of Maternal Vitamin D Deficiency with Pregnancy and Neonatal Complications in Developing Countries: A Systematic Review. Nutrients 2018 May 18;10(5). pii: E640. doi: 10.3390/nu10050640
  • http://www.who.int/elena/titles/vitamind_supp_pregnancy/en/
  • ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol 2011 Jul;118(1):197-8. doi: 10.1097/AOG.0b013e318227f06b.
  • Canadian Pediatric Society. Vitamin D supplementation: Recommenda- tions for Canadian mothers and infants. J Paediatr Child Health 2007;12: 583–598.

Ankara İlinde Gebelerde 25-Hidroksi Vitamin D ve Paratiroid Hormon Düzeylerinin Kesitsel İncelemesi

Year 2019, Volume: 16 Issue: 3, 152 - 154, 01.07.2019
https://doi.org/10.4274/jcrpe.4706

Abstract

Amaç: Vitamin D eksikliği gebelikte sık görülür. Çalışmamızda geniş bir Türk gebe kohortu değerlendirildi, gebelik süresince D vitamini eksikliği insidansı ve vitamin desteği alma oranlarının saptanması amaçlandı.Gereç ve Yöntemler: Haziran - Aralık 2013 tarihleri arasında hastanemiz gebelik izlem poliklinliğine başvuran ve gönüllü olan gebeler ile , yeme alışkanlıkları, yaşam tarzları ve vitamin takviyesi ile ilgili soruların yer aldığı bir anket gerçekleştirdi. Yazılı onamı alınan gebelerden D vitamini ve Paratiroid hormon düzeylerini ölçmek için kan örnekleri alındı.Bulgular: Toplam 1088 gebe analiz edildi. Ortalama D vitamini düzeyi 17.5 ± 9.9 ng / mL ve PTH 18.7 ± 11.4 pg / ml idi. Vitamin D eksikliği

References

  • Holick MF. Vitamin D: evolutionary, physiological and health perspecti- ves. Curr Drug Targets2011; 12: 4-18.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96:1911–30.
  • Xiao JP, Zang J, Pei JJ, Xu F, Zhu Y, Liao XP. Low maternal vitamin D sta- tus during the second trimester of pregnancy: a cross-sectional study in Wuxi, China. PLoS One 2015 6;10(2):e0117748.
  • Gür EB, Turan GA, Tatar S, Gökduman A, Karadeniz M, Celik G, et al. Theeffect of place of residenceandlifestyle on vitamin D deficiency in pregnancy: Comparison of easternand western parts of Turkey. J Turk GerGynecolAssoc 2014;15:149-55.
  • Gür G, Abaci A, Köksoy AY, Anik A, Catli G, Kişlal FM, et al. Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a prelimi- narystudy. Turk J Med Sci 2014; 44: 616-23.
  • https://www.saglik.gov.tr/TR,11158/gebelere-d-vitamini-destek-progra- mi.html
  • Marshall I, Mehta R, Petrova A. Vitamin D in the maternal–fetal–neonatal interface: Clinical implications and requirements for supplementation. J Matern Fetal Neonatal Med 2013;26:633–8
  • Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011;26:2341–57
  • Song SJ, Zhou L, Si S, et al. The high prevalence of vitamin D deficiency and its related maternal factors in pregnant women in Beijing. PLoS One 2013;8: e85081.
  • Shibata M, Suzuki A, Sekiya T, et al. High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab 2011;29:615–20
  • Milman N, Hvas AM, Bergholt T. Vitamin D status during normal preg- nancy and postpartum. A longitudinal study in 141 Danish women. J Perinat Med 2011;40:57–61 .
  • Özdemir AA, Ercan Gündemir Y, Küçük M, Yıldıran Sarıcı D, Elgörmüş Y, Çağ Y, Bilek G.Vitamin D Deficiency in Pregnant Women and Their Infants.J Clin Res Pediatr Endocrinol 2018 Mar 1;10(1):44-50. doi: 10.4274/jcrpe.4706
  • Kılıcaslan AÖ, Kutlu R, Kilinc I, Ozberk DI.The effects of vitamin D supp- lementation during pregnancy and maternal vitamin D levels on neonatal vitamin D levels and birth parameters.J Matern Fetal Neonatal Med 2018 Jul;31(13):1727-1734
  • Gür G, Abaci A, Köksoy AY, Anik A, Catli G, Kişlal FM, Akin KO, Andiran N.Incidence of maternal vitamin D deficiency in a region of Ankara, Tur- key: a preliminary study.Turk J Med Sci 2014;44(4):616-23.
  • Aydogmus S, Kelekci S, Aydogmus H, Eriş S, Desdicioğlu R, Yilmaz B, Sağlam G.High prevalence of vitamin D deficiency among pregnant wo- men in a Turkish population and impact on perinatal outcomes.J Matern Fetal Neonatal Med 2015;28(15):1828-32
  • Parlak M, Kalay S, Kalay Z, Kirecci A, Guney O, Koklu E.Severe vitamin D deficiency among pregnant women and their newborns in Turkey.J Matern Fetal Neonatal Med 2015 Mar;28(5):548-51
  • van der Pligt P, Willcox J, Szymlek-Gay EA, Murray E, Worsley A, Daly RM.Associations of Maternal Vitamin D Deficiency with Pregnancy and Neonatal Complications in Developing Countries: A Systematic Review. Nutrients 2018 May 18;10(5). pii: E640. doi: 10.3390/nu10050640
  • http://www.who.int/elena/titles/vitamind_supp_pregnancy/en/
  • ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol 2011 Jul;118(1):197-8. doi: 10.1097/AOG.0b013e318227f06b.
  • Canadian Pediatric Society. Vitamin D supplementation: Recommenda- tions for Canadian mothers and infants. J Paediatr Child Health 2007;12: 583–598.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Gülsüm Kadıoğlu Şimşek This is me

Fuat Emre Canpolat This is me

Hayriye Gözde Kanmaz Kutmaz This is me

Sema Arayıcı This is me

Halil İbrahim Yakut This is me

Özlem Moraloğlu This is me

Behzat Özkan This is me

Publication Date July 1, 2019
Published in Issue Year 2019 Volume: 16 Issue: 3

Cite

Vancouver Kadıoğlu Şimşek G, Canpolat FE, Kanmaz Kutmaz HG, Arayıcı S, Yakut Hİ, Moraloğlu Ö, Özkan B. Ankara İlinde Gebelerde 25-Hidroksi Vitamin D ve Paratiroid Hormon Düzeylerinin Kesitsel İncelemesi. JGON. 2019;16(3):152-4.