Comparison Of Hematologic Parameters In Patients With Positive vs. Negative Surgical Margins After Conization

Year 2018, Volume: 15 Issue: 1, 10 - 13, 01.01.2018

İbrahim Yalçın , Mustafa Erkan Sarı Hanifi Şahin Vakkas Korkmaz Nazlı Topfedaisi Özkan Mehmet Mutlu Meydanlı Tayfun Güngör

Abstract

Aim: To evaluate the utility of complete blood count to predict positive surgical margins after cold knife conization CKC .Material and Methods: Woman who underwent CKC because of biopsy - proven high-grade squamous intraepithelial lesions HSIL between 2009 and 2013 were retrospectively analyzed. Out of 231 woman in total, primarily referring 63 surgical margin positive women were included as the study group Group 1 , 168 surgical margin negative women were selected as the control group Group 2 . The relation between the positive surgical margins and age, height of cone, depth of cone, diameter of cone, complete blood count parameters was assessed.Results: The mean age of the patients were 41.9 years. The conization result of all patients’ in Group 1 was HSIL. The conization results of Group 2 were microinvasive carcinoma, HSIL, low-grade squamous lesion LSIL and no residual disease for 5, 108, 35 and 20 patients, respectively. 52 women in Group 1 underwent either repeat excisional procedure or simple hysterectomy and 24 of them showed residual disease. There was no statistically significant difference in regard to neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and mean platelet volume MPV occurred between two groups p=0.7, p=0.96 and p=0.81 respectively .Conclusion: Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and MPV do not seem to be useful in predicting positive surgical margins after CKC.

Keywords

Cold knife conization, mean platelet volume, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, surgical margin

Konizasyon Sonrası Pozitif Ve Negatif Cerrahi Sınırı Olan Hastalarda Hematolojik Parametrelerin Karşılaştırılması

Abstract

Giriş: Tam kan sayımı parametrelerinin soğuk konizasyon sonrası cerrahi sınır pozitifliğini predikte etmesindeki faydasının değerlendirilmesi.Gereç ve Yöntemler: 2009 – 2013 yılları arasında biyopsi tanısı yüksek grade skuamöz intraepitelyal lezyon olup soğuk konizasyon uygulanan hastalar retrospektif olarak incelendi. 63 cerrahi sınır pozitif hasta çalışma grubu Grup 1 ve 168 cerrahi sınır negatif hasta kontrol grubu Grup 2 olmak üzere toplamda 231 hasta çalışmaya dahil edildi. Pozitif cerrahi sınırlar ile yaş, koni boyu, koni derinliği, koni çapı ve tam kan sayımı parametrelerinin ilişkisi değerlendirildi.Bulgular: Hastaların ortalama yaşı 41.9’du. Grup 1’deki bütün hastaların konizasyon sonrası patoloji sonucu yüksek grade skuamöz intraepitelyal lezyondu. Grup 2’deki 5 hastanın konizasyon sonrası patoloji sonucu mikroinvaziv karsinom, 108 hastanın yüksek grade skuamöz intraepitelyal lezyon, 35 hastanın düşük grade skuamöz intraepitelyal lezyon ve 20 hastanın patoloji sonucu ise normal olarak raporlandı. Grup 1’deki 52 hastaya tekrar eksizyonel prosedür veya basit histerektomi uygulandı. Bu hastaların 24’ünde rezidüel hastalık saptandı. Her iki grup arasında nötrofil/lenfosit oranı, platelet/lenfosit oranı ve ortalama platelet volümü açısından istatistiksel olarak anlamlı bir farklılık saptanmadı Sırasıyla p=0.7, p=0.96 ve p=0.81 .Sonuç: Nötrofil/lenfosit oranı, platelet/lenfosit oranı ve ortalama platelet volümü soğuk konizasyon sonrası pozitif cerrahi sınırı predikte etmede faydalı olarak gözükmemektedir.

Keywords

Cerrahi sınır, nötrofil/lenfosit oranı, ortalama platelet volümü, platelet/lenfosit oranı, soğuk konizasyon

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