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Comparison Of Some Cycle Characteristics Between Poor Responder Women With And Without Oocyte Retrieval Following Transvaginal Follicle Aspiration

Year 2017, Volume: 14 Issue: 4, 151 - 154, 01.10.2017

Bülent Emre Bilgiç Enis Özkaya Tayfun Kutlu Semra Kayataş Eser İlhan Sanverdi Simge Bağcı Türkmen

Abstract

Aim: The aim of this study was to figure out the differences in the cycle characteristics differences between poor responder women with and without oocyte retrieval with transvaginal follicle aspiration.Material and Method: Some cycle characteristics of sixty-eight women with no oocyte retrieval were compared with sixty women with at least one oocyte retrieval following transvaginal follicle aspiration. All women had poor ovarian reserve determined by basal FSH, estradiol, AMH levels and antral follicle count. Diminished ovarian reserve was defined according to the basal FSH value >10 IU/L, antral follicle count

Keywords

empty follicle syndrome granulosa cell apoptosis poor ovarian reserve

References

  • Kim JH, Jee BC. Empty follicle syndrome. Clin Exp Reprod Med. 2012 Dec;39(4):132-7.
  • Uygur D, Alkan RN, Batuoğlu S. Recurrent empty follicle syndrome. J Assist Reprod Genet. 2003 Sep;20(9):390-2.
  • Reichman DE, Greenwood E, Meyer L, Kligman I, Rosenwaks Z. Can in vitro fertilization cycles be salvaged by repeat administration of intra- muscular human chorionic gonadotropin the day after failed injection? Fertil Steril. 2012 Sep;98(3):671-4.
  • Zegers-Hochschild F, Fernández E, Mackenna A, Fabres C, Altieri E, Lo- pez T. The empty follicle syndrome: a pharmaceutical industry syndrome. Hum Reprod. 1995 Sep;10(9):2262-5.
  • Stevenson TL, Lashen H. Empty follicle syndrome: the reality of a contro- versial syndrome, a systematic review. Fertil Steril. 2008 Sep;90(3):691- 8.
  • Hourvitz A, Maman E, Brengauz M, Machtinger R, Dor J. In vitro matura- tion for patients with repeated in vitro fertilization failure due to “oocyte maturation abnormalities”. Fertil Steril. 2010 Jul;94(2):496-501.
  • Tsuiki A, Rose BI, Hung TT. Steroid profiles of follicular fluids from a pa- tient with the empty follicle syndrome. Fertil Steril 1988 Jan;49(1):104- 107.
  • MeniruGI,CraftIL. Evidencefromasalvagedtreatmentcycle supports an aetiology for the empty follicle syndrome that is related to terminal folli- cular developmental events. Hum Reprod 1997 Nov;12(11):2385-2387.
  • Aktas M, Beckers NG, van Inzen WG, Verhoeff A, de Jong D. Oocy- tes in the empty follicle: a controversial syndrome. Fertil Steril 2005 Dec;84(6):1643-1648.
  • Baum M, Machtinger R, Yerushalmi GM, Maman E, Seidman DS, Dor J, et al. Recurrence of empty follicle syndrome with stimulated IVF cycles. Gynecol Endocrinol 2012 Apr;28(4):293-295.
  • Castillo JC, Garcia-Velasco J, Humaidan P. Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS. J Assist Reprod Genet 2012 Mar;29(3):249-253.
  • Zhang J. Luteal phase ovarian stimulation following oocyte retrieval: is it helpful for poor responders?. Reprod Biol Endocrinol. 2015 Jul 25;13:76.
  • Cohen J, Chabbert-Buffet N, Darai E. Diminished ovarian reserve, prema- ture ovarian failure, poor ovarian responder--a plea for universal definiti- ons. J Assist Reprod Genet. 2015 Dec;32(12):1709-12.
  • Zreik TG, Garcia-Velasco JA, Vergara TM, Arici A, Olive D, Jones EE. Empty follicle syndrome: evidence for recurrence. Hum Reprod 2000 May;15(5):999-1002.
  • Younis JS, Skournik A, Radin O, Haddad S, Bar-Ami S, Ben- Ami M. Poor oocyte retrieval is a manifestation of low ovarian reserve. Fertil Steril 2005 Feb;83(2):504-507.
  • Beck-Fruchter R, Weiss A, Lavee M, Geslevich Y, Shalev E. Empty follicle syndrome: successful treatment in a recurrent case and review of the literature. Hum Reprod 2012 May;27(5):1357-1367.
  • Bustillo M. Unsuccessful oocyte retrieval: technical artefact or genuine ‘empty follicle syndrome’? Reprod Biomed Online 2004 Jan;8(1):59-67.
  • Madani T, Jahangiri N. Empty Follicle Syndrome: The Possible Cause of Occurrence. Oman Med J. 2015 Nov;30(6):417-20.
  • Billig H, Chun SY, Eisenhauer K, Hsueh AJ. Gonadal cell apoptosis: hormone-regulated cell demise. Hum Reprod Update. 1996 Mar- Apr;2(2):103-17.
  • Greenseid K, Jindal S, Zapantis A, Nihsen M, Hurwitz J, Pal L. Declining ovarian reserve adversely influences granulosa cell viability. Fertil Steril. 2009 Jun;91(6):2611-5.
  • Y. Fan, L. Wei, Y. Shi, J. Chen, X. Liang. Apoptosis of granulosa cells and clinical outcomes between normal and poor ovarian reserve patients undergoing IVF/ICSI. P-43 Tuesday, October 18, 2016
  • Ahmed K. Allow, Sadek S. M. Abdulmogny A2, Bracamonte Maryam3, Khilood Naji Ghafouri Al- Ani4, Muhammed-Baqir Fakhrildin4 and Wael Muhamad. The Relationship between Duration of Infertility and Intrauteri- ne Insemination: A Multi-Centers Study. Journal of Clinical Developmen- tal Biology 2016; 1(3):1-7

Transvajinal Folikül Aspirasyonunu Takiben Oosit Toplanabilen ve Toplanamayan Kötü Yanıtlı Hastaların Siklus Karakteristiklerinin Karşılaştırılması

Year 2017, Volume: 14 Issue: 4, 151 - 154, 01.10.2017

Bülent Emre Bilgiç Enis Özkaya Tayfun Kutlu Semra Kayataş Eser İlhan Sanverdi Simge Bağcı Türkmen

Abstract

Giriş: Bu çalışmanın amacı, zayıf yanıtlı hastalarda transvajinal folikül aspirasyonu sonrası oosit elde edilen ve edilmeyen grupların siklus özelliklerini belirlemektir.Gereç ve Yöntem: Zayıf yanıtlı olup folikül aspirasyonu sonrası hiç oosit çıkmayan 68 hasta ile en az bir oosit çıkan 60 hastalanın bazı siklus özellikleri karşılaştırıldı. Tüm hastalarda bazal FSH, estradiol ve AMH değerlerine göre karar verilen düşük over rezervi mevcuttu. Düşük over rezervi, FSH değeri > 10 IU/L, antral folikül sayısı < 6 veya AMH < 1.1 ng/ml veya daha önceden zayıf cevap olarak tanımlandı.Sonuçlar: İki grup arasında, infertilite süresi, bazal östradiol süresi ve 14 mm nin üzerindeki folikül sayısı ve tetikleme günü pik estradiol düzeyleri 397 versus 1301 pg/ml bakımından anlamlı fark mevcuttu. Çok değişkenli regresyon analizinde, infertilite süresi ve pik estradiol süresi oosit toplama prosedürü sonrası hiç oosit çıkmaması ile ilişkili saptanmıştır. Pik östradiol düzeyi AUC=0.888, P < 0.001 ve infertilite süresi AUC=0.776, P < 0.001 hiç oosit çıkmamasını anlamlı öngörmekteydi. Pik östradiol için optimal eşik değer 412 pg/ml 88% sensitivite, 70% spesifisite % , infertilite süresi için ise 4.75 yıl 72 % sensitivite, 75% spesifisite olarak saptandı.Tartışma: Tetikleme günü bakılan pik östradiol düzeyi zayıf cevaplı hastalarda transvajinal oosit aspirasyon işlemi sonrası hiç oosit elde edilmemesini öngörmek üzere kullanılabilir.

Keywords

boş folikül sendromu granuloza hücre apoptozu düşük over rezervi

References

  • Kim JH, Jee BC. Empty follicle syndrome. Clin Exp Reprod Med. 2012 Dec;39(4):132-7.
  • Uygur D, Alkan RN, Batuoğlu S. Recurrent empty follicle syndrome. J Assist Reprod Genet. 2003 Sep;20(9):390-2.
  • Reichman DE, Greenwood E, Meyer L, Kligman I, Rosenwaks Z. Can in vitro fertilization cycles be salvaged by repeat administration of intra- muscular human chorionic gonadotropin the day after failed injection? Fertil Steril. 2012 Sep;98(3):671-4.
  • Zegers-Hochschild F, Fernández E, Mackenna A, Fabres C, Altieri E, Lo- pez T. The empty follicle syndrome: a pharmaceutical industry syndrome. Hum Reprod. 1995 Sep;10(9):2262-5.
  • Stevenson TL, Lashen H. Empty follicle syndrome: the reality of a contro- versial syndrome, a systematic review. Fertil Steril. 2008 Sep;90(3):691- 8.
  • Hourvitz A, Maman E, Brengauz M, Machtinger R, Dor J. In vitro matura- tion for patients with repeated in vitro fertilization failure due to “oocyte maturation abnormalities”. Fertil Steril. 2010 Jul;94(2):496-501.
  • Tsuiki A, Rose BI, Hung TT. Steroid profiles of follicular fluids from a pa- tient with the empty follicle syndrome. Fertil Steril 1988 Jan;49(1):104- 107.
  • MeniruGI,CraftIL. Evidencefromasalvagedtreatmentcycle supports an aetiology for the empty follicle syndrome that is related to terminal folli- cular developmental events. Hum Reprod 1997 Nov;12(11):2385-2387.
  • Aktas M, Beckers NG, van Inzen WG, Verhoeff A, de Jong D. Oocy- tes in the empty follicle: a controversial syndrome. Fertil Steril 2005 Dec;84(6):1643-1648.
  • Baum M, Machtinger R, Yerushalmi GM, Maman E, Seidman DS, Dor J, et al. Recurrence of empty follicle syndrome with stimulated IVF cycles. Gynecol Endocrinol 2012 Apr;28(4):293-295.
  • Castillo JC, Garcia-Velasco J, Humaidan P. Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS. J Assist Reprod Genet 2012 Mar;29(3):249-253.
  • Zhang J. Luteal phase ovarian stimulation following oocyte retrieval: is it helpful for poor responders?. Reprod Biol Endocrinol. 2015 Jul 25;13:76.
  • Cohen J, Chabbert-Buffet N, Darai E. Diminished ovarian reserve, prema- ture ovarian failure, poor ovarian responder--a plea for universal definiti- ons. J Assist Reprod Genet. 2015 Dec;32(12):1709-12.
  • Zreik TG, Garcia-Velasco JA, Vergara TM, Arici A, Olive D, Jones EE. Empty follicle syndrome: evidence for recurrence. Hum Reprod 2000 May;15(5):999-1002.
  • Younis JS, Skournik A, Radin O, Haddad S, Bar-Ami S, Ben- Ami M. Poor oocyte retrieval is a manifestation of low ovarian reserve. Fertil Steril 2005 Feb;83(2):504-507.
  • Beck-Fruchter R, Weiss A, Lavee M, Geslevich Y, Shalev E. Empty follicle syndrome: successful treatment in a recurrent case and review of the literature. Hum Reprod 2012 May;27(5):1357-1367.
  • Bustillo M. Unsuccessful oocyte retrieval: technical artefact or genuine ‘empty follicle syndrome’? Reprod Biomed Online 2004 Jan;8(1):59-67.
  • Madani T, Jahangiri N. Empty Follicle Syndrome: The Possible Cause of Occurrence. Oman Med J. 2015 Nov;30(6):417-20.
  • Billig H, Chun SY, Eisenhauer K, Hsueh AJ. Gonadal cell apoptosis: hormone-regulated cell demise. Hum Reprod Update. 1996 Mar- Apr;2(2):103-17.
  • Greenseid K, Jindal S, Zapantis A, Nihsen M, Hurwitz J, Pal L. Declining ovarian reserve adversely influences granulosa cell viability. Fertil Steril. 2009 Jun;91(6):2611-5.
  • Y. Fan, L. Wei, Y. Shi, J. Chen, X. Liang. Apoptosis of granulosa cells and clinical outcomes between normal and poor ovarian reserve patients undergoing IVF/ICSI. P-43 Tuesday, October 18, 2016
  • Ahmed K. Allow, Sadek S. M. Abdulmogny A2, Bracamonte Maryam3, Khilood Naji Ghafouri Al- Ani4, Muhammed-Baqir Fakhrildin4 and Wael Muhamad. The Relationship between Duration of Infertility and Intrauteri- ne Insemination: A Multi-Centers Study. Journal of Clinical Developmen- tal Biology 2016; 1(3):1-7
There are 22 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Bülent Emre Bilgiç This is me

Enis Özkaya This is me

Tayfun Kutlu This is me

Semra Kayataş Eser This is me

İlhan Sanverdi This is me

Simge Bağcı Türkmen This is me

Publication Date October 1, 2017
Published in Issue Year 2017 Volume: 14 Issue: 4

Cite

Vancouver Bilgiç BE, Özkaya E, Kutlu T, Kayataş Eser S, Sanverdi İ, Bağcı Türkmen S. Transvajinal Folikül Aspirasyonunu Takiben Oosit Toplanabilen ve Toplanamayan Kötü Yanıtlı Hastaların Siklus Karakteristiklerinin Karşılaştırılması. JGON. 2017;14(4):151-4.