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Analysis Of The Therapeutic Pregnancy Terminations For Fetal Reasons In a Perinatology Center

Year 2017, Volume: 14 Issue: 2, 70 - 73, 01.04.2017

Abstract

Aim: This study was intended to analyze the therapeutic pregnancy terminations for fetal reasons in our perinatology clinic and describe the spectrum of fetal anomalies. Material and Methods: This retrospective study included patients who applied for therapeutic pregnancy terminations for fetal reasons to University of Health Sciences Zekai Tahir Burak Women Health, Research and Practice Center between January and December 2015. Patients’ demographic characteristics, congenital anomaly diagnose center, final decision of Health Board, spectrum of pregnancy termination reasons, and the results of chromosomal analysis of fetuses after termination are recorded for this descriptive analysis. Results: During the study period, a total of 268 pregnant women applied to our Health Board for pregnancy termination and 96% of these pregnancies n=258 had fetal reasons. The most common application for therapeutic pregnancy termination was NTDs 40.6% followed by chromosomal abnormalities 14.7% , anhydramnios 14.2% , central nervous system abnormalities 6.2% , hydrops fetalis 4.6% , urinary system abnormalities 4.2% , fetal multiple organ abnormalities syndromes 3.8% , cardiac malformations 3.1% , teratogenic drug use 2.3% , skeletal dysplasias 1.1% , intrauterine infections 1.1% , abdominal wall defects 0.7% , fetal metabolic diseases 0.3% . Postmortem genetic analysis was applied to 50 fetus 19.3 % and abnormal chromosomal caryotype was found in 18 of them 36 % . Conclusion: In Turkey researchers are in need of birth defects monitoring programs which would enlight causative factors of birth defects.

References

  • Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. Abortion. Williams Obstetrics. 24th ed. 2014;Chapter 18, p363.
  • Grimes, DA; Stuart, G. Abortion jabberwocky: the need for better termi- nology. Contraception 2010; 81 (2): 93–6.
  • EUROCAT Working Group. Eurocat report 7: 15 years of surveillance of congenital anomalies in Europe 1980-1994.
  • EUROCAT(2009) http://www.eurocatnetwork.eu/ACCESSPREVALENCE- DATA/Prevalence
  • Turkish penal code 99-6.
  • The Population Planning Law. Law No. 2827 of 24 May 1983.
  • Adzick NS, Thom EA, Spong CY, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D’Alton ME, Farmer DL. A randomized trial of prenatal versus post- natal repair of myelomeningocele. N Engl J Med 2011; 364: 993–1004.
  • EURO-PERISTAT Project, with SCPE, EUROCAT, EURONEOSTAT, (2008) European Perinatal Health Report. Chapter 9: Congenital Anomalies: EUROCAT
  • Dolk H (B) EUROCAT Central Registry, Faculty of Life and Health Sciences, University of Ulster, Newtownabbey, Co Antrim, BT37 0QB, UK. Khoury MJ. Epidemiology of birth defects. Epidemiol Rev 1989;11:244–8.
  • Dolk H, Loane M, Garne E: The prevalence of congenital anomalies in Europe. Adv Exp Med Biol 2010;686:349.
  • Wilson RD, De Bie I, Armour CM at all. Joint SOGC-CCMG Opinion for Reproductive Genetic Carrier Screening: An Update for All Canadian Providers of Maternity and Reproductive Healthcare in the Era of Dire- ct-to-Consumer Testing. J Obstet Gynaecol Can 2016; 38:742-762

Perinatoloji Merkezinde Fetal Nedenlerden Dolayı Yapılan Terapötik Gebelik Terminasyonlarının Analizi

Year 2017, Volume: 14 Issue: 2, 70 - 73, 01.04.2017

Abstract

Giriş: Bu çalışma perinatoloji kliniğimizde fetal nedenlerden dolayı yapılan terapötik gebelik terminasyonlarını analiz etmeyi ve anomalilerin spektrumunu tanımlamayı amaçladı. Gerec ve Yöntemler: Bu retrospektif calışma, 1 Ocak - 31 Aralik 2015 tarihleri arası Sağlık Bilimleri Üniversitesi Zekai Tahir Burak Kadın Sağlığı, Uygulama ve Araştırma merkezine fetal nedenlerden dolayi terapötik gebelik terminasyonu icin basvuran hastaları içerdi. Hastaların demografik özellikleri, konjenital anomali tanısı aldıkları merkez, Sağlık Kurulunun son kararı, terminasyon yapılacak anomalilerin spektrumu ve terminasyon yapılan fetüslerin kromozomal analiz sonuçları bu tanımlayıcı çalışma için kaydedildi. Bulgular: Sağlık Kurulumuza, çalışma süreci boyunca gebelik terminasyonu talebi ile 268 gebe başvurdu ve bu gebeliklerin %96’sı fetal nedenlere sahipti. Terapötik gebelik terminasyonu için en yaygın başvuru nedeni nöral tüp defektleri NTD idi %40.6 ve bunu sırasıyla kromozomal anormallikler %14.7 , anhidramnioz %14.2 , santral sinir sistemi anormallikleri %6.2 , hidrops fetalis %4.6 , üriner sistem anormallikleri %4.2 , fetal çoklu organ anomalileri Sendromlar %3.8 , kardiyak malformasyonlar %3.1 , kistik higroma %2.3 , teratojenik ilaç kullanımı %2.3 , iskelet displazileri %1.1 , intrauterin enfeksiyonlar %1.1 , karın ön duvarı defektleri %0.7 ve fetal metabolik hastalıklar %0.3 takip etti. Postmortem genetik analiz 50 fetuse %19.3 uygulandı ve bu fetuslerin 18’inde anormal kromozomal karyotip %36 bulundu. Sonuc: Türkiye’de araştırmacılar, doğum defektlerinin etkenlerini aydınlatacak doğum defektleri izleme programlarına ihtiyaç duymaktadırlar.

References

  • Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. Abortion. Williams Obstetrics. 24th ed. 2014;Chapter 18, p363.
  • Grimes, DA; Stuart, G. Abortion jabberwocky: the need for better termi- nology. Contraception 2010; 81 (2): 93–6.
  • EUROCAT Working Group. Eurocat report 7: 15 years of surveillance of congenital anomalies in Europe 1980-1994.
  • EUROCAT(2009) http://www.eurocatnetwork.eu/ACCESSPREVALENCE- DATA/Prevalence
  • Turkish penal code 99-6.
  • The Population Planning Law. Law No. 2827 of 24 May 1983.
  • Adzick NS, Thom EA, Spong CY, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D’Alton ME, Farmer DL. A randomized trial of prenatal versus post- natal repair of myelomeningocele. N Engl J Med 2011; 364: 993–1004.
  • EURO-PERISTAT Project, with SCPE, EUROCAT, EURONEOSTAT, (2008) European Perinatal Health Report. Chapter 9: Congenital Anomalies: EUROCAT
  • Dolk H (B) EUROCAT Central Registry, Faculty of Life and Health Sciences, University of Ulster, Newtownabbey, Co Antrim, BT37 0QB, UK. Khoury MJ. Epidemiology of birth defects. Epidemiol Rev 1989;11:244–8.
  • Dolk H, Loane M, Garne E: The prevalence of congenital anomalies in Europe. Adv Exp Med Biol 2010;686:349.
  • Wilson RD, De Bie I, Armour CM at all. Joint SOGC-CCMG Opinion for Reproductive Genetic Carrier Screening: An Update for All Canadian Providers of Maternity and Reproductive Healthcare in the Era of Dire- ct-to-Consumer Testing. J Obstet Gynaecol Can 2016; 38:742-762
There are 11 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Şule Özel This is me

Erdinç Sarıdoğan This is me

Esra Şükran Çakar This is me

Hatice Çelik This is me

Aykan Yücel This is me

Salim Erkaya This is me

Yaprak Üstün Engin This is me

Publication Date April 1, 2017
Published in Issue Year 2017 Volume: 14 Issue: 2

Cite

Vancouver Özel Ş, Sarıdoğan E, Çakar EŞ, Çelik H, Yücel A, Erkaya S, Üstün Engin Y. Perinatoloji Merkezinde Fetal Nedenlerden Dolayı Yapılan Terapötik Gebelik Terminasyonlarının Analizi. JGON. 2017;14(2):70-3.