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Environmental And Occupational Exposure to Toxicants As Risk Factor For Neural Tube Defects

Year 2017, Volume: 14 Issue: 2, 82 - 86, 01.04.2017

Abstract

Aim: Neural tube defects NTD constitute one of the most common congenital malformations of the central nervous system which originate during embryogenesis. The failure in the morphogenetic process of neural tube closure results with NTD. Genetic and environmental factors play role in the pathogenesis of NTD. Gene polymorphisms in folate metabolism is accepted as the primary determinant while environmental and occupational factors contribute to etiology. A number of epidemiologic and clinical studies have investigated the potential association between environmental and occupational exposure to noxious chemicals and NTD. We reviewed some of these studies which have investigated the potential etiological role of heavy metals lead, arsenic, mercury, cadmium and manganese , pesticides, solvents and polycyclic aromatic hydrocarbons in NTD.

References

  • Copp, A. J., Stanier, P., Greene, N.. Neural tube defects: recent advances, unsolved questions, and controversies. The Lancet Neurology. 2013; 12: 799-810
  • Aksu H., Sevil Ü. Yurtsev E., Güvendiren G., Nöral tüp defektleri ve folik asit. Maltepe Üniversitesi Hemşirelik Bilim ve Sanat Dergisi 2010; 2,139- 144.
  • Tunçbilek, Ergül. “Türkiye’deki yüksek nöral tüp defekti sıklığı ve önlemek için yapılabilecekler.” Çocuk Sağlığı ve Hastalıkları Dergisi. 2004; 47.2 : 79-84.
  • Padmanabhan R. Etiology, pathogenesis and prevention of neural tube defects.Congenit Anom (Kyoto). 2006;46:55-67
  • Salih MA, Murshid WR, Seidahmed MZ. Classification, clinical features, and genetics of neural tube defects. Saudi Med J. 2014 ;35:5-14.
  • Beaudin AE, Stover PJ. Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol 2009; 85: 274-284.
  • Copp AJ, Stanier P, Greene ND. Neural tube defects: recent advances, un- solved questions, and controversies. Lancet Neurol. 2013;12:799-810
  • Alagüney, M. E., Bal, C., Hocaoglu, A., Büyükşekerci, M., Tutkun, L., & Yılmaz, O. H. (2015). The trace element pattern in occupationallead exposed workers. Toxicology Letters, 238, S147-S148.
  • Cengiz B, Söylemez F, Oztürk E, Cavdar AO. Serum zinc, selenium, cop- per, and lead levels in women with second-trimester induced abortion resulting from neural tube defects: a preliminary study. Biol Trace Elem Res. 2004;97:225-35.
  • Bound JP, Harvey PW, Francis BJ, Awwad F, Gatrell AC. Involvementof- deprivationandenviron mental lead in neural tube defects: a matched ca- se-control study. ArchDis Child. 1997;76:107-12.
  • Irgens A, Krüger K, Skorve AH, Irgens LM. Reproductive outcome in of- fspring of parents occupationally exposed to lead in Norway. Am J Ind Med. 1998;34:431-7
  • Yakub, Mohsin, and Mohammad Perwaiz Iqbal. “Association of blood lead (Pb) and plasma homocysteine: a crosssectional survey in Karachi, Pakistan.”PLoS One 2010;5.7
  • Büyükşekerci, M., Bal, C., Alagüney, M. E., Ağış, E. R., Gündüzöz, M., Hocaoğlu, A., ve ark Evaluation of folate and vitamin B12 levels in lead exposed workers. 2015; Dicle Tıp Dergisi, 42(3).
  • Brender JD, Suarez L, Felkner M, Gilani Z, Stinchcomb D, Moody K, Hen- ry J,Hendricks K. Maternal exposure to arsenic, cadmium, lead, and mer- cury and neural tube defects in offspring. Environ Res. 2006; 101:132-9
  • Carrillo-Ponce Mde L, Martínez-Ordaz VA, Velasco-Rodríguez VM, Her- nández-García A, Hernández-Serrano MC, Sanmiguel F. Serum lead, cadmium, andzinclevels in newborns with neural tube defects from a pollutedzone in Mexico. Reprod Toxicol. 2004;19:149-54.
  • Mohammed Abdul KS, Jayasinghe SS, Chandana EP, Jayasumana C, De Silva PM. Arsenic and human health effects: A review. Environ Toxicol Pharmacol. 2015; 40:828-46
  • Mazumdar M, Valeri L, Rodrigues EG, Ibne Hasan MO, Hamid R, Paul L, Selhub J, Silva F, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC. Polymorphisms in maternal folate pathway genes interact with arse- nic in drinking water to influence risk of myelomeningocele. Birth Defects Res A Clin Mol Teratol. 2015;103:754-62
  • Mazumdar M, Ibne Hasan MO, Hamid R, Valeri L, Paul L, Selhub J, Rod- rigues EG, Silva F, Mia S, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC. Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh. Envi- ron Health. 2015;14:34.
  • Jin L, Zhang L, Li Z, Liu JM, Ye R, Ren A. Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population. Reprod Toxicol. 2013;35:25-31
  • Guzzi G, La Porta CA. Molecular mechanism striggered by mercury. Toxi- cology. 2008; 3;244:1-12.
  • Agency for Toxic Substances and Disease Registry, Division of Toxico- logy, 1999. Toxicolgical Profi le for Mercury . Update Draft for Public Comments. ATSDR, Atlanta GA.
  • Farina M, Avila DS, da Rocha JB, Aschner M. Metals, oxidative stres and neurode generation: a focus on iron, manganese and mercury. Neuroc- hem Int. 2013:62:575-94.
  • Domingo JL. Metal-induced developmental toxicity in mammals: a re- view. J Toxicol Environ Health. 1994;42:123-41.
  • Luevano J, Damodaran C. A review of molecular events of cadmium-in- duced carcinogenesis. J Environ Pathol Toxicol Oncol. 2014;33:183-94.
  • A gency for Toxic Substances and Disease Registry, Division of Toxico- logy, 2012.Toxicolgical Profile for manganese . Update Draft for Public Comments. ATSDR, Atlanta GA.
  • Agency for Toxic Substances and Disease Registry, Division of Toxico- logy, 2012. Toxicolgical Profile for Manganese. Update Draft for Public Comments. ATSDR, Atlanta GA.
  • Liu J, Jin L, Zhang L, Li Z, Wang L, Ye R, Zhang Y, Ren A. Placental concentrations of manganese and the risk of fetal neural tube defects. J Trace Elem Med Biol. 2013;27:322-5
  • Mamane A, Raherison C, Tessier JF, Baldi I, Bouvier G. Environmen- tal exposure to pesticides and respiratory health. Eur Respir Rev. 2015;24:462-73.
  • Anwar WA. Biomarkers of human expo sure to pesticides. Environ Health Perspect.1997;105; 4:801-6.
  • Wang B, Yi D, Jin L, Li Z, Liu J, Zhang Y, Qiu X, Liu W, Tao S, Ren A.Or- ganochlorine pesticide levels in maternal serum and risk of neural tube defectsin offspring in Shanxi Province, China: a case-control study. Sci Total Environ. 2014;490:1037-43
  • Brender, J. D., Felkner, M., Suarez, L., Canfield, M. A., & Henry, J. P.). Ma- ternal pesticide exposure and neural tube defects in Mexican .Americans. Annals of epidemiology, 2010; 20, 16-22.
  • Desrosiers TA, Lawson CC, Meyer RE, Richardson DB, Daniels JL, Wa- ters MA, et al.Defects Prevention Study. Maternal occupational expo sure to organic solvents during early pregnancy and risks of neural tube defe- cts and oro facial clefts. Occup Environ Med. 2012;69:493-9
  • Lupo PJ, Symanski E, Waller DK, Chan W, Langlois PH, Canfield MA, Mit- chell LE.Maternal exposure to ambient levels of benzene and neural tube defects among off spring: Texas, 1999-2004. Environ Health Perspect. 2011;119:397-402.
  • Brender JD, Shinde MU, Zhan FB, Gong X, Langlois PH. Maternal resi- dential proximity to chlorinated solvent emissions and birth defects in offspring: a case-control study. Environ Health. 2014;13:96.
  • Aguilar-Garduño C, Lacasaña M, Blanco-Muñoz J, Borja-Aburto VH, Gar- cía AM. Parental occupational exposure to organic solvents and anen- cephaly in Mexico. Occup Environ Med. 2010;67:32-7.
  • Logman JF, de Vries LE, Hemels ME, Khattak S, Einarson TR. Paternal organic solvent exposure and adverse pregnancy outcomes: a meta-a- nalysis. Am J Ind Med. 2005;47:37-44
  • Brender JD, Suarez L. Paternal occupation and anencephaly. Am J Epide- miol. 1990 ;131:517-21.
  • Kamal A, Cincinelli A, Martellini T, Malik RN. A review of PAH exposure from the combustion of biomass fuel and their less survey e deffect on the blood parameters. Environ Sci Pollut Res Int. 2015;22:4076-98.
  • Wang B, Jin L, Ren A, Yuan Y, Liu J, Li Z, et al.. Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring. Environ Sci Technol. 2015;49:588-96
  • Yi D, Yuan Y, Jin L, Zhou G, Zhu H, Finnell RH, Ren A. Levels of PAH-DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population. Neurotoxicology. 2015;46:73-8.
  • Langlois PH, Hoyt AT, Lupo PJ, Lawson CC, Waters MA, Desrosiers TA, Shaw GM,Romitti PA, Lammer EJ; National Birth Defects Prevention Study. Maternal occupational exposure to polycyclic aromatic hydrocar- bons and risk of neural tube defect-affected pregnancies. Birth Defects Res A Clin Mol Teratol. 2012;94:693-700
  • Ren A, Qiu X, Jin L, Ma J, Li Z, Zhang L, Zhu H, Finnell RH, Zhu T. Asso- ciation of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proc Natl Acad Sci U S A. 2011;108:12770-5.

Nöral Tüp Defekti Risk Faktörü Olarak Çevresel ve Mesleki Toksik Madde Maruziyeti

Year 2017, Volume: 14 Issue: 2, 82 - 86, 01.04.2017

Abstract

Amaç: Nöral tüp defektleri NTD embriyonik gelişim esnasında ortaya çıkan ve santral sinir sisteminin en sık rastlanan doğumsal anomalisidir. Nöral tüpün morfogenetik kapanmasındaki bozukluk NTD ile sonuçlanır. NTD patogenezinde genetik ve çevresel faktörler rol alır. NTD etiyolojisinde folat metabolizmasındaki gen polimorfizmleri asıl etken olarak kabul edilirken çevresel ve mesleki faktörlerin de katkısı vardır. Çok sayıda epidemiyolojik ve klinik araştırmada NTD ile çevresel ve mesleki toksik madde maruziyeti ilişkisi incelenmiştir. Bizler bu makalede NTD etiyolojisinde ağır metaller kurşun, arsenik, civa, kadmiyum, ve manganez , pestisitler, solventler ve polisiklik aromatik hidrokarbonların etkilerini inceleyen çalışmaları derledik.

References

  • Copp, A. J., Stanier, P., Greene, N.. Neural tube defects: recent advances, unsolved questions, and controversies. The Lancet Neurology. 2013; 12: 799-810
  • Aksu H., Sevil Ü. Yurtsev E., Güvendiren G., Nöral tüp defektleri ve folik asit. Maltepe Üniversitesi Hemşirelik Bilim ve Sanat Dergisi 2010; 2,139- 144.
  • Tunçbilek, Ergül. “Türkiye’deki yüksek nöral tüp defekti sıklığı ve önlemek için yapılabilecekler.” Çocuk Sağlığı ve Hastalıkları Dergisi. 2004; 47.2 : 79-84.
  • Padmanabhan R. Etiology, pathogenesis and prevention of neural tube defects.Congenit Anom (Kyoto). 2006;46:55-67
  • Salih MA, Murshid WR, Seidahmed MZ. Classification, clinical features, and genetics of neural tube defects. Saudi Med J. 2014 ;35:5-14.
  • Beaudin AE, Stover PJ. Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol 2009; 85: 274-284.
  • Copp AJ, Stanier P, Greene ND. Neural tube defects: recent advances, un- solved questions, and controversies. Lancet Neurol. 2013;12:799-810
  • Alagüney, M. E., Bal, C., Hocaoglu, A., Büyükşekerci, M., Tutkun, L., & Yılmaz, O. H. (2015). The trace element pattern in occupationallead exposed workers. Toxicology Letters, 238, S147-S148.
  • Cengiz B, Söylemez F, Oztürk E, Cavdar AO. Serum zinc, selenium, cop- per, and lead levels in women with second-trimester induced abortion resulting from neural tube defects: a preliminary study. Biol Trace Elem Res. 2004;97:225-35.
  • Bound JP, Harvey PW, Francis BJ, Awwad F, Gatrell AC. Involvementof- deprivationandenviron mental lead in neural tube defects: a matched ca- se-control study. ArchDis Child. 1997;76:107-12.
  • Irgens A, Krüger K, Skorve AH, Irgens LM. Reproductive outcome in of- fspring of parents occupationally exposed to lead in Norway. Am J Ind Med. 1998;34:431-7
  • Yakub, Mohsin, and Mohammad Perwaiz Iqbal. “Association of blood lead (Pb) and plasma homocysteine: a crosssectional survey in Karachi, Pakistan.”PLoS One 2010;5.7
  • Büyükşekerci, M., Bal, C., Alagüney, M. E., Ağış, E. R., Gündüzöz, M., Hocaoğlu, A., ve ark Evaluation of folate and vitamin B12 levels in lead exposed workers. 2015; Dicle Tıp Dergisi, 42(3).
  • Brender JD, Suarez L, Felkner M, Gilani Z, Stinchcomb D, Moody K, Hen- ry J,Hendricks K. Maternal exposure to arsenic, cadmium, lead, and mer- cury and neural tube defects in offspring. Environ Res. 2006; 101:132-9
  • Carrillo-Ponce Mde L, Martínez-Ordaz VA, Velasco-Rodríguez VM, Her- nández-García A, Hernández-Serrano MC, Sanmiguel F. Serum lead, cadmium, andzinclevels in newborns with neural tube defects from a pollutedzone in Mexico. Reprod Toxicol. 2004;19:149-54.
  • Mohammed Abdul KS, Jayasinghe SS, Chandana EP, Jayasumana C, De Silva PM. Arsenic and human health effects: A review. Environ Toxicol Pharmacol. 2015; 40:828-46
  • Mazumdar M, Valeri L, Rodrigues EG, Ibne Hasan MO, Hamid R, Paul L, Selhub J, Silva F, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC. Polymorphisms in maternal folate pathway genes interact with arse- nic in drinking water to influence risk of myelomeningocele. Birth Defects Res A Clin Mol Teratol. 2015;103:754-62
  • Mazumdar M, Ibne Hasan MO, Hamid R, Valeri L, Paul L, Selhub J, Rod- rigues EG, Silva F, Mia S, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC. Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh. Envi- ron Health. 2015;14:34.
  • Jin L, Zhang L, Li Z, Liu JM, Ye R, Ren A. Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population. Reprod Toxicol. 2013;35:25-31
  • Guzzi G, La Porta CA. Molecular mechanism striggered by mercury. Toxi- cology. 2008; 3;244:1-12.
  • Agency for Toxic Substances and Disease Registry, Division of Toxico- logy, 1999. Toxicolgical Profi le for Mercury . Update Draft for Public Comments. ATSDR, Atlanta GA.
  • Farina M, Avila DS, da Rocha JB, Aschner M. Metals, oxidative stres and neurode generation: a focus on iron, manganese and mercury. Neuroc- hem Int. 2013:62:575-94.
  • Domingo JL. Metal-induced developmental toxicity in mammals: a re- view. J Toxicol Environ Health. 1994;42:123-41.
  • Luevano J, Damodaran C. A review of molecular events of cadmium-in- duced carcinogenesis. J Environ Pathol Toxicol Oncol. 2014;33:183-94.
  • A gency for Toxic Substances and Disease Registry, Division of Toxico- logy, 2012.Toxicolgical Profile for manganese . Update Draft for Public Comments. ATSDR, Atlanta GA.
  • Agency for Toxic Substances and Disease Registry, Division of Toxico- logy, 2012. Toxicolgical Profile for Manganese. Update Draft for Public Comments. ATSDR, Atlanta GA.
  • Liu J, Jin L, Zhang L, Li Z, Wang L, Ye R, Zhang Y, Ren A. Placental concentrations of manganese and the risk of fetal neural tube defects. J Trace Elem Med Biol. 2013;27:322-5
  • Mamane A, Raherison C, Tessier JF, Baldi I, Bouvier G. Environmen- tal exposure to pesticides and respiratory health. Eur Respir Rev. 2015;24:462-73.
  • Anwar WA. Biomarkers of human expo sure to pesticides. Environ Health Perspect.1997;105; 4:801-6.
  • Wang B, Yi D, Jin L, Li Z, Liu J, Zhang Y, Qiu X, Liu W, Tao S, Ren A.Or- ganochlorine pesticide levels in maternal serum and risk of neural tube defectsin offspring in Shanxi Province, China: a case-control study. Sci Total Environ. 2014;490:1037-43
  • Brender, J. D., Felkner, M., Suarez, L., Canfield, M. A., & Henry, J. P.). Ma- ternal pesticide exposure and neural tube defects in Mexican .Americans. Annals of epidemiology, 2010; 20, 16-22.
  • Desrosiers TA, Lawson CC, Meyer RE, Richardson DB, Daniels JL, Wa- ters MA, et al.Defects Prevention Study. Maternal occupational expo sure to organic solvents during early pregnancy and risks of neural tube defe- cts and oro facial clefts. Occup Environ Med. 2012;69:493-9
  • Lupo PJ, Symanski E, Waller DK, Chan W, Langlois PH, Canfield MA, Mit- chell LE.Maternal exposure to ambient levels of benzene and neural tube defects among off spring: Texas, 1999-2004. Environ Health Perspect. 2011;119:397-402.
  • Brender JD, Shinde MU, Zhan FB, Gong X, Langlois PH. Maternal resi- dential proximity to chlorinated solvent emissions and birth defects in offspring: a case-control study. Environ Health. 2014;13:96.
  • Aguilar-Garduño C, Lacasaña M, Blanco-Muñoz J, Borja-Aburto VH, Gar- cía AM. Parental occupational exposure to organic solvents and anen- cephaly in Mexico. Occup Environ Med. 2010;67:32-7.
  • Logman JF, de Vries LE, Hemels ME, Khattak S, Einarson TR. Paternal organic solvent exposure and adverse pregnancy outcomes: a meta-a- nalysis. Am J Ind Med. 2005;47:37-44
  • Brender JD, Suarez L. Paternal occupation and anencephaly. Am J Epide- miol. 1990 ;131:517-21.
  • Kamal A, Cincinelli A, Martellini T, Malik RN. A review of PAH exposure from the combustion of biomass fuel and their less survey e deffect on the blood parameters. Environ Sci Pollut Res Int. 2015;22:4076-98.
  • Wang B, Jin L, Ren A, Yuan Y, Liu J, Li Z, et al.. Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring. Environ Sci Technol. 2015;49:588-96
  • Yi D, Yuan Y, Jin L, Zhou G, Zhu H, Finnell RH, Ren A. Levels of PAH-DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population. Neurotoxicology. 2015;46:73-8.
  • Langlois PH, Hoyt AT, Lupo PJ, Lawson CC, Waters MA, Desrosiers TA, Shaw GM,Romitti PA, Lammer EJ; National Birth Defects Prevention Study. Maternal occupational exposure to polycyclic aromatic hydrocar- bons and risk of neural tube defect-affected pregnancies. Birth Defects Res A Clin Mol Teratol. 2012;94:693-700
  • Ren A, Qiu X, Jin L, Ma J, Li Z, Zhang L, Zhu H, Finnell RH, Zhu T. Asso- ciation of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proc Natl Acad Sci U S A. 2011;108:12770-5.
There are 42 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Murat Büyükşekerci This is me

Ömer Hınç Yılmaz This is me

Fatma Meriç Yılmaz This is me

Publication Date April 1, 2017
Published in Issue Year 2017 Volume: 14 Issue: 2

Cite

Vancouver Büyükşekerci M, Yılmaz ÖH, Yılmaz FM. Nöral Tüp Defekti Risk Faktörü Olarak Çevresel ve Mesleki Toksik Madde Maruziyeti. JGON. 2017;14(2):82-6.