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The Diagnostic Utility Of Clinical Features And Tumor Marker Levels In Patients With Ovarian Mature Cystic Teratoma

Year 2015, Volume: 12 Issue: 5, 171 - 173, 01.09.2015

Abstract

Aim: The aim of this study is to evaluate the effect of clinical features and tumor marker levels to preoperative diagnosis in patients with ovarian mature cystic teratomas MCT .Material and Methods: Demographic features, clinical features and tumor markers of 201 patients, who were operated at our hospital from 2012 to 2015 and confirmed pathologically as having ovarian MCT were evaluated retrospectively. Age of the patients, gravida, parity, menopausal status, bilaterality, clinical symptoms, operation type and tumor marker levels are evaluated and expressed as mean± standard deviation, and percents.Results: The mean age of the patients was 34, 76 ±12,83 years. 79,7% of the patients were at reproductive age group. 13,4% of the patients were at post menoposal age, 4,4% of the patients were pregnant and 2,5% of the patients were at premenarchial period. Bilaterality rate was 10,2%. The most common clinical symptom was pelvic pain with 67,7% and laparoscopy was with 68,2% the most common operation performed. Mean tumor marker levels like AFP, CEA, Ca 19-9 and Ca-125 were 4,0; 1,5; 18,5 and 29,4 IU/ml, respectively.Conclusion: Clinical features especially ultrasound have been shown to be significant markers for the diagnosis of ovarian MCT. We believe a good clinical evaluation preoperatively will make the main contribution to the diagnosis.

References

  • Ayhan A, Bükülmez O, Genç C, Karamürsel BS, Ayhan A, Mature cystic teratomas of the ovary: Case series from one institution over 34 years. Eur J Obstet Gynecol Reprod Biol 2000;88:153-7.
  • Vercellini P, Chapron C, De Giorgi O, Consonni D, Frontino G, Crosignani PG. Coagulation or excision of ovarian endometriomas? Am J Obstet Gynecol 2003; 188:606-610.
  • Mecke H, Savvas V. Laparoscopic surgery of dermoidcysts-intra operati- vespillage and complications. Obstet Gynecol Reprod Biol 2001; 96:80- 84.
  • Ferrari MM, Mezzopane R, Bulfoni A, Grijuela B, Carminati R, Ferrazzi E, PardiG. Surgical treatment of ovarian dermoid cysts: a comparison between laparoscopic and vaginal removal. Eur J Obstet Gynecol Reprod Biol 2003; 109:88-91.
  • Outwater EK, Siegelman ES, Hunt JL. Ovarian teratomas: Tumor types and imaging characteristics. Radiographics 2001;21:475-90.
  • Emin U, Tayfun G, Cantekin I, Özlem UB, Ümit B, Leyla M. Tumor mar- kers in mature cystic teratomas of the ovary. Arch Gynecol Obstet 2009;279:145-7.
  • Martange G, Ditto A, LaMarco A, Trotta V, De Leo V. Surgical treatment of ovarian dermoid cysts. Obstet Gynecol 1988; 81:47-50.
  • Sah SP, Uprety D, Rani S. Germ cell tumors of the ovary: A clinicopatho- logic study of 121 cases from Nepal. J Obstet Gynecol Res 2004;30:303- 8.
  • Özgür T, Atik E, Silfeler DB, Toprak S. Mature cystic teratomas in our se- ries with review of the literatüre and retrospective analysis. Arch Gynecol Obstet 2012;285:1099-101.
  • Walid MS, Boddy MG. Bilateral dermoid cysts of the ovary in a pregnant woman: Case report and review of the literatüre. Arch Gynecol Obstet 2009;279:105-8.
  • Sah SP, Verma K, Rani S. Neurogeniccyst of ovary: an unusual massive monodermalteratoma. J Obstet Gynaecol Res 2001; 27:21–25
  • Papadias K, Kairi-Vassilatou K, ArgeitisJ, Kondis-Pafitis A, Greatsas G. Teratomas of theovary: A clinico-pathological evaluation of 87 patients from one institution during a 10-year period. Eur J Gynecol Oncol 2005; 26: 446-8.
  • Patel MD, Feldstein VA, Lipson SD, Chen DC, Filly RA. Cystic terato- mas of the ovary: Diagnostic value of sonography. AJR Am J Roentgenol 1998;171:1061-5.
  • Kikkawa F, Nawa A, Tamakoshi K, Ishikawa H, Kuzuya K, Suganuma N, et al. Diagnosis of squamouscell carcinomaa rising from mature cystic teratoma of the ovary. Cancer 1998;82:2249-55.

Ovaryan Matür Kistik Teratom Olgularında Tanıya Yaklaşımda Tümör Belirteçlerinin ve Klinik Özelliklerin Önemi

Year 2015, Volume: 12 Issue: 5, 171 - 173, 01.09.2015

Abstract

Amaç: Bu çalışmanın amacı ovaryan matür kistik teratomlu MKT olgulardaki klinik özelliklerin ve tümör belirteçlerinin preoperatif tanıya olan etkilerinin araştırılmasıdır.Gereç ve Yöntemler: Hastanemizde 2012-2015 tarihleri arasında opere edilen ve kesin patoloji sonucu ovaryan MKT olan 201 hastanın demografik, klinik özellikleri ve tümör markerları retrospektif olarak taranmıştır. Hastaların yaş, gravida, parite, menapozal durum, bilateralite, klinik semptom, yapılan operasyonun şekli ve tümör marker seviyeleri değerlendirilerek sonuçlar, ortalama ± standart deviasyon ve yüzdelik dilimler olarak belirtilmiştir.Bulgular: Hastaların ortalama yaşı 34,76 ±12,83 olarak saptandı. Reprodüktif dönemde olan hasta oranı %79,7 iken, % 13,4’ü postmenopozal dönemde, %4,4‘ü gebe kalan %2,5 ise premenarşal dönemdeydi. Bilateralite oranı %10,2 saptandı. En sık klinik semptom %66,7 ile kasık ağrısı ve en sık yapılan operasyon şekli %68,2 ile laparoskopiydi. Tümör markerlarından AFP, CEA, Ca 19-9 ve Ca-125 ortalama seviyeleri sırasıyla 4,0; 1,5; 18,5 ve 29,4 IU/ml olarak tespit edildi.Sonuç: Ovaryan MKT’ların tanısında başta ultrasonografi olmak üzere, klinik özelliklerin önemli belirteçler olduğu görülmüştür. Preoperatif dönemde iyi bir klinik değerlendirme yapılmasının, tanıya en çok katkıyı sağlayacağı kanaatindeyiz.

References

  • Ayhan A, Bükülmez O, Genç C, Karamürsel BS, Ayhan A, Mature cystic teratomas of the ovary: Case series from one institution over 34 years. Eur J Obstet Gynecol Reprod Biol 2000;88:153-7.
  • Vercellini P, Chapron C, De Giorgi O, Consonni D, Frontino G, Crosignani PG. Coagulation or excision of ovarian endometriomas? Am J Obstet Gynecol 2003; 188:606-610.
  • Mecke H, Savvas V. Laparoscopic surgery of dermoidcysts-intra operati- vespillage and complications. Obstet Gynecol Reprod Biol 2001; 96:80- 84.
  • Ferrari MM, Mezzopane R, Bulfoni A, Grijuela B, Carminati R, Ferrazzi E, PardiG. Surgical treatment of ovarian dermoid cysts: a comparison between laparoscopic and vaginal removal. Eur J Obstet Gynecol Reprod Biol 2003; 109:88-91.
  • Outwater EK, Siegelman ES, Hunt JL. Ovarian teratomas: Tumor types and imaging characteristics. Radiographics 2001;21:475-90.
  • Emin U, Tayfun G, Cantekin I, Özlem UB, Ümit B, Leyla M. Tumor mar- kers in mature cystic teratomas of the ovary. Arch Gynecol Obstet 2009;279:145-7.
  • Martange G, Ditto A, LaMarco A, Trotta V, De Leo V. Surgical treatment of ovarian dermoid cysts. Obstet Gynecol 1988; 81:47-50.
  • Sah SP, Uprety D, Rani S. Germ cell tumors of the ovary: A clinicopatho- logic study of 121 cases from Nepal. J Obstet Gynecol Res 2004;30:303- 8.
  • Özgür T, Atik E, Silfeler DB, Toprak S. Mature cystic teratomas in our se- ries with review of the literatüre and retrospective analysis. Arch Gynecol Obstet 2012;285:1099-101.
  • Walid MS, Boddy MG. Bilateral dermoid cysts of the ovary in a pregnant woman: Case report and review of the literatüre. Arch Gynecol Obstet 2009;279:105-8.
  • Sah SP, Verma K, Rani S. Neurogeniccyst of ovary: an unusual massive monodermalteratoma. J Obstet Gynaecol Res 2001; 27:21–25
  • Papadias K, Kairi-Vassilatou K, ArgeitisJ, Kondis-Pafitis A, Greatsas G. Teratomas of theovary: A clinico-pathological evaluation of 87 patients from one institution during a 10-year period. Eur J Gynecol Oncol 2005; 26: 446-8.
  • Patel MD, Feldstein VA, Lipson SD, Chen DC, Filly RA. Cystic terato- mas of the ovary: Diagnostic value of sonography. AJR Am J Roentgenol 1998;171:1061-5.
  • Kikkawa F, Nawa A, Tamakoshi K, Ishikawa H, Kuzuya K, Suganuma N, et al. Diagnosis of squamouscell carcinomaa rising from mature cystic teratoma of the ovary. Cancer 1998;82:2249-55.
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Kerem Doğa Seçkin This is me

Berna Aslan Çetin This is me

Mehmet Fatih Karslı This is me

Çağdaş Özdemir This is me

Burak Yücel This is me

Ali Emre Tahaoğlu This is me

Hüseyin Kıyak This is me

Gökhan Yıldırım This is me

Publication Date September 1, 2015
Published in Issue Year 2015 Volume: 12 Issue: 5

Cite

Vancouver Seçkin KD, Çetin BA, Karslı MF, Özdemir Ç, Yücel B, Tahaoğlu AE, Kıyak H, Yıldırım G. Ovaryan Matür Kistik Teratom Olgularında Tanıya Yaklaşımda Tümör Belirteçlerinin ve Klinik Özelliklerin Önemi. JGON. 2015;12(5):171-3.