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Comparison of the clinical and laboratory outcomes in adolescent and adults with polycystic ovary syndromeComparison of the clinical and laboratory outcomes in adolescent and adults with polycystic ovary syndrome

Year 2014, Volume: 11 Issue: 3, 82 - 84, 01.07.2014

Abstract

Background: Polycystic Ovary Syndrome PCOS is the leading cause of anovulation, hirsutism, and infertility in women of all ages. It is associated with ovulatory dysfunction beginning in the perimenarchal period, hyperandrogenism, hyperinsulinemia, and insulin resistance. For adult women the prevalence of PCOS ranges from 3% to 23%. There are no established diagnostic criteria for the diagnosis of PCOS in adolescents. Both the National Institutes of Health and the Rotterdam criteria are used in practice. We used Rotterdam criteria for the diagnosis. In current study, we compared the clinical and laboratory outcomes in adolescents and adults with PCOS.Materials and Methods: Females aged 10 to 18 years old for the adolescent group and aged 25 to 32 years old for the reproductive age group with a diagnosis of PCOS using the Rotterdam criteria enrolled in the study. Risk factors were recorded; BMI body mass index, Waist/hip, FSH, LH, E2, PRL, TSH, Total Testosterone, Free Testosterone, Insulin, HOMA IR.Results: There was no statistical significance between the groups in terms of BMI, waist/hip, FSH, E2, LH/FSH, PRL, TSH. However, LH, Total Testosterone, Free Testosterone, Insulin, HOMA-IR values were statistically significantly different between the groups.Conclusion: Our study showed that hyperandrogenism, and insulin values are seen higher in adolescent PCOS than adult PCOS. In our opinion, there may be a likely relationship between these findings and metabolic differences in puberty.

References

  • Orsino A, Van Eyk N, Hamilton J. Clinical features, investigations and management of adolescents with polycystic ovary syndrome. Paediatr Child Health. 2005;10:602-8.
  • Rotterdam ESHRE/ASRM - Sporsored PCOS consensus workshop groups. Revised 2003 consensus on diagnostic criteria and long- term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41-7.
  • Cırık DA, Dilbaz B. What do we know about metabolic syndrome in adolescents with PCOS? J Turk Ger Gynecol Assoc. 2014;15:49- 55.
  • Khan U. Polycystic ovary syndrome in adolescents. J Pediatr Adolesc Gynecol. 2007;20:101-4.
  • Lewy VD, Danadian K, Witchel SF, Arslanian S. Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome. J Pediatr. 2001;138:38-44.
  • Christensen SB, Black MH, Smith N, Martinez MM, Jacobsen SJ, Porter AH, et al. Prevalence of polycystic ovary syndrome in adolescents. Fertil Steril. 2013;100:470-7.
  • Eagleson CA, Gingrich MB, Pastor CL, Arora TK, Burt CM, Evans WS, et al. Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J C Endocrinol Metabol 2000;85:4047-52.
  • Arslanian SA, Lewy VD, Danadian K. Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease. J Clin Endocrinol Metab. 2001;86:66-71.
  • Bloch CA, Clemons P, Sperling MA. Puberty decreases insulin sensitivity. J Pediatr. 1987;110:481-7.
  • Amiel SA, Caprio S, Sherwin RS, Plewe G, Haymond MW, Tamborlane WV. Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism. J Clin Endocrinol Metabol 1991;72:277-82.
  • Smith CP, Archibald HR, Thomas JM, Tarn AC, Williams AJ, Gale EA, et al. Basal and stimulated insulin levels rise with advancing puberty. Clin Endocrinol 1988;28:7-14.
  • Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487-95.
  • Sultan C, Paris F. Clinical expression of polycystic ovary syndrome in adolescent girls. Fertil Steril. 2006;86 Suppl 1:S6.
  • van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Endocrine features of polycystic ovary syndrome in a random population sample of 14-16 year old adolescents. Human Reprod 1999;14:2223-9.
  • Diamanti-Kandarakis E. PCOS in adolescents. Best Pract Res Clin Obstet Gynaecol. 2010;24:173-83.
  • Gooding HC, Milliren C, St Paul M, Mansfield MJ, Divasta A. Diagnosing Dysglycemia in Adolescents With Polycystic Ovary Syndrome. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. 2014.
  • Pasquali R, Gambineri A. Therapy in endocrine disease: treatment of hirsutism in the polycystic ovary syndrome. Eur J Endocrinol. 2014;170:R75-90.
  • Kirchengast S, Peterson B, Hauser G, Knogler W. Body composition characteristics are associated with the bone density of the proximal femur end in middle- and old-aged women and men. Maturitas. 2001;39:133-45.
  • Carmina E, Lobo RA. Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 2004;82:661-5.
  • Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol. 2013;6:1-13.

Polikistik over sendromunun adolesan ve erişkinlerde klinik ve laboratuar parametreler açısından karşılaştırılması

Year 2014, Volume: 11 Issue: 3, 82 - 84, 01.07.2014

Abstract

Amaç: Polikistik over sendromu PKOS kadınlarda anovulasyon, hirşutism ve infertilitenin en önemli nedenidir. Perimenarş döneminde başlayan ovulatuar disfonksiyon, hiperandrojenizm, hiperinsülinemi ve insülin resistansıyla ilişkilidir. Reprodüktif çağdaki kadınlarda prevelansı %3-23 arasında değişmektedir. Adolesanlarda PKOS tanısı için tanımlanmış kriterler mevcut değildir. National Institutes of Health ve Rotterdam kriterleri pratikte halen kullanılmaktadır. Biz çalışmamızda; Rotterdam kriterlerini tanı için kullandık ve polikistik over sendromu tanısı almış adolesan ve reprodüktif çağdaki kadınları klinik ve laboratuar parametreler açısından karşılaştırdık. Gereç ve Yöntemler: Çalışmamıza Rotterdam kriterlerine göre PKOS tanısı konulmuş 14-18 yaşları arasındaki adolesan kızlar ve 25-32 yaşları arasında reprodüktif çağdaki kadınlar dahil edildi. Vücut kitle endeksi VKI , bel-kalça oranı ve serum FSH, LH, E2, PRL, TSH, total testosteron, serbest testosteron, insülin, HOMA-IR düzeyleri her iki grupta hesaplandı. Bulgular: VKI, bel-kalça oranı, serum FSH, E2, PRL, TSH ve LH/FSH oranı her iki grupta benzer bulundu. Ancak serum LH, total testosteron, serbest testosteron, insülin, HOMA-IR değerleri gruplar arasında istatistiksel olarak farklı bulundu. Sonuç: Çalışmamızda, hiperandrojenizm ve insülin değerleri adolesan PKOS’larda erişkin çağdaki PKOS’lu kadınlara göre daha yüksek bulundu. Bize göre, bu bulgular ile pubertede meydana gelen metabolik değişiklikler arasında ilişki olabilir.

References

  • Orsino A, Van Eyk N, Hamilton J. Clinical features, investigations and management of adolescents with polycystic ovary syndrome. Paediatr Child Health. 2005;10:602-8.
  • Rotterdam ESHRE/ASRM - Sporsored PCOS consensus workshop groups. Revised 2003 consensus on diagnostic criteria and long- term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41-7.
  • Cırık DA, Dilbaz B. What do we know about metabolic syndrome in adolescents with PCOS? J Turk Ger Gynecol Assoc. 2014;15:49- 55.
  • Khan U. Polycystic ovary syndrome in adolescents. J Pediatr Adolesc Gynecol. 2007;20:101-4.
  • Lewy VD, Danadian K, Witchel SF, Arslanian S. Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome. J Pediatr. 2001;138:38-44.
  • Christensen SB, Black MH, Smith N, Martinez MM, Jacobsen SJ, Porter AH, et al. Prevalence of polycystic ovary syndrome in adolescents. Fertil Steril. 2013;100:470-7.
  • Eagleson CA, Gingrich MB, Pastor CL, Arora TK, Burt CM, Evans WS, et al. Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J C Endocrinol Metabol 2000;85:4047-52.
  • Arslanian SA, Lewy VD, Danadian K. Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease. J Clin Endocrinol Metab. 2001;86:66-71.
  • Bloch CA, Clemons P, Sperling MA. Puberty decreases insulin sensitivity. J Pediatr. 1987;110:481-7.
  • Amiel SA, Caprio S, Sherwin RS, Plewe G, Haymond MW, Tamborlane WV. Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism. J Clin Endocrinol Metabol 1991;72:277-82.
  • Smith CP, Archibald HR, Thomas JM, Tarn AC, Williams AJ, Gale EA, et al. Basal and stimulated insulin levels rise with advancing puberty. Clin Endocrinol 1988;28:7-14.
  • Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487-95.
  • Sultan C, Paris F. Clinical expression of polycystic ovary syndrome in adolescent girls. Fertil Steril. 2006;86 Suppl 1:S6.
  • van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Endocrine features of polycystic ovary syndrome in a random population sample of 14-16 year old adolescents. Human Reprod 1999;14:2223-9.
  • Diamanti-Kandarakis E. PCOS in adolescents. Best Pract Res Clin Obstet Gynaecol. 2010;24:173-83.
  • Gooding HC, Milliren C, St Paul M, Mansfield MJ, Divasta A. Diagnosing Dysglycemia in Adolescents With Polycystic Ovary Syndrome. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. 2014.
  • Pasquali R, Gambineri A. Therapy in endocrine disease: treatment of hirsutism in the polycystic ovary syndrome. Eur J Endocrinol. 2014;170:R75-90.
  • Kirchengast S, Peterson B, Hauser G, Knogler W. Body composition characteristics are associated with the bone density of the proximal femur end in middle- and old-aged women and men. Maturitas. 2001;39:133-45.
  • Carmina E, Lobo RA. Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 2004;82:661-5.
  • Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol. 2013;6:1-13.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Hasan Onur Topcu This is me

Seda Topçu This is me

Aslı Oskovi This is me

Ali İrfan Güzel This is me

Yaprak Engin Üstün This is me

Nedim Çiçek This is me

Nafiye Yılmaz This is me

Publication Date July 1, 2014
Published in Issue Year 2014 Volume: 11 Issue: 3

Cite

Vancouver Topcu HO, Topçu S, Oskovi A, Güzel Aİ, Üstün YE, Çiçek N, Yılmaz N. Polikistik over sendromunun adolesan ve erişkinlerde klinik ve laboratuar parametreler açısından karşılaştırılması. JGON. 2014;11(3):82-4.