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Perinataland Maternal Consequences of Pregnancies Complicated with Sickle Cell Anemia

Year 2014, Volume: 11 Issue: 2, 33 - 36, 01.04.2014

Abstract

Background: Although most of the pregnancies with maternal sickle cell anemia SCA give live births, these pregnancies have increased risk for maternal and fetal complications.The aim of present study is to investigate maternal and fetal complications in pregnancies with SCA and SCA trait in Hatay city. Methods:The study population consisted of 150 pregnancies who applied to obstetrics and gynecology outpatient clinics 50 SCA pregnancies, 50 SCA trait pregnancies and 50 pregnancies without chronic disease . Patients’ blood count, number of the transfusions during pregnancy, maternal and fetal complications gestational age at delivery, mode of delivery, birth weight, 1 and 5 minute APGAR scores were recorded. Results:The number of blood transfusions during pregnancy was higher in SCA and SCA trait groups p

References

  • 1. Patra PK, Chauhan VS, Khodiar PK, Dalla AR, Serjeant GR. Screening for the sickle cell gene in Chhattisgarh state, India: an approach to a major public health problem. Journal of Community Genetics. 2011;2:147-51.
  • 2. Bunn HF. Pathogenesis and treatment of sickle cell disease. New England JMed 1997;337:762-9.
  • 3. Smith JA, Espeland M, Bellevue R, Bonds D, Brown AK, Koshy M. Pregnancy in sickle cell disease: experience of the Cooperative Study of Sickle Cell Disease. ObstetGynecol. 1996;87:199-204.
  • 4. Serjeant GR, Loy LL, Crowther M, Hambleton IR, Thame M. Outcome of pregnancy in homozygous sickle cell disease. Obstet and gynecol 2004;103:1278-85..
  • 5. Pregnancy, contraception and fertility. In: Standards for the Clinical Care of Adults with Sickle Cell Disease in the UK, 2008. p.59.
  • 6. Leborgne-Samuel Y, Kadhel P, Ryan C, Vendittelli F. [Sickle cell disease and pregnancy]. La Revue du praticien. 2004;54:1578-82. Epub 2004/11/24. La femme enceinte drepanocytaire.
  • 7. Villers MS, Jamison MG, De Castro LM, James AH. Morbidity associated with sickle cell disease in pregnancy. AmJ Obstet Gynecol 2008;199:125 e1-5.
  • 8. Al Jama FE, Gasem T, Burshaid S, Rahman J, Al Suleiman SA, Rahman MS. Pregnancy outcome in patients with homozygous sickle cell disease in a university hospital, Eastern Saudi Arabia. Arch Gynecol Obstet 2009;280:793-7.
  • 9. Diallo D, Tchernia G. Sickle cell disease in Africa. Current opinion in hematology. 2002;9:111-6. 10. Altay Ç. Abnormal Hemoglobins in Turkey. Turk J Haematol. 2002;19:63–74.
  • 11. Sağlık Bakanlığı Riskli Gebelikler Yönetim Rehberi; 2014.
  • 12. Asnani MR, McCaw-Binns AM, Reid ME. Excess risk of maternal death from sickle cell disease in Jamaica: 1998-2007. PloS one. 2011;6:e26281.
  • 13. Boulet SL, Okoroh EM, Azonobi I, Grant A, Craig Hooper W. Sickle cell disease in pregnancy: maternal complications in a Medicaid-enrolled population. Maternal and child health journal. 2013;17:200-7.
  • 14. el-Shafei AM, Sandhu AK, Dhaliwal JK. Maternal mortality in Bahrain with special reference to sickle cell disease. Australian New ZealJ Obstet Gynecol 1988;28:41-4.
  • 15. Pintova S, Cohen HW, Billett HH. Sickle cell trait: is there an increased VTE risk in pregnancy and the postpartum? PloS one. 2013;8:e64141.
  • 16. Koh MB, Lao ZT, Rhodes E. Managing haematological disorders during pregnancy. Best Prac Res Clin Obstet Gynecol 2013;27:855-65.
  • 17. Reducing the Risk of Thrombosis and Embolism during Pregnancy and the Puerperium (Green-top 37a). Royal college of medicine guideline 2009.
  • 18. Zia S, Rafique M. Comparison of pregnancy outcomes in women with sickle cell disease and trait. JPMA 2013;63:743-6.

Orak Hücre Anemisi Olan Gebelerde Perinatal ve Maternal Sonuçlar

Year 2014, Volume: 11 Issue: 2, 33 - 36, 01.04.2014

Abstract

Amaç: Maternal orak hücreli anemi hastalığı SCA olan gebeliklerin çoğu canlı doğum ile sonuçlanmasına karşın, bu gebeliklerde fetal ve maternal komplikasyonlar için artmış risk söz konusudur. Çalışmanın amacı Hatay ilinde orak hücreli anemisi ve SCA taşıyıcı olan gebelerde maternal ve fetal komplikasyonları araştırmaktır. Gereç ve Yöntem: Çalışmaya kadın doğum polikliniğine başvuran 150 gebe dahil edildi 50 SCA gebe, 50 SCA taşıyıcısı olan gebe ve 50 kronik hastalığı olmayan gebe . Hastaların hemogram değerleri, gebeliğinde yapılan transfüzyon sayısı, maternal ve fetal komplikasyonlar, doğum haftası, doğum şekli, doğum ağırlığı, 1. ve5. dakika APGAR skoru kaydedildi. Bulgular: Gebelikte transfüzyon yapılan gebe sayısı SCA ve SCA taşıyıcı grupta daha fazlaydı p

References

  • 1. Patra PK, Chauhan VS, Khodiar PK, Dalla AR, Serjeant GR. Screening for the sickle cell gene in Chhattisgarh state, India: an approach to a major public health problem. Journal of Community Genetics. 2011;2:147-51.
  • 2. Bunn HF. Pathogenesis and treatment of sickle cell disease. New England JMed 1997;337:762-9.
  • 3. Smith JA, Espeland M, Bellevue R, Bonds D, Brown AK, Koshy M. Pregnancy in sickle cell disease: experience of the Cooperative Study of Sickle Cell Disease. ObstetGynecol. 1996;87:199-204.
  • 4. Serjeant GR, Loy LL, Crowther M, Hambleton IR, Thame M. Outcome of pregnancy in homozygous sickle cell disease. Obstet and gynecol 2004;103:1278-85..
  • 5. Pregnancy, contraception and fertility. In: Standards for the Clinical Care of Adults with Sickle Cell Disease in the UK, 2008. p.59.
  • 6. Leborgne-Samuel Y, Kadhel P, Ryan C, Vendittelli F. [Sickle cell disease and pregnancy]. La Revue du praticien. 2004;54:1578-82. Epub 2004/11/24. La femme enceinte drepanocytaire.
  • 7. Villers MS, Jamison MG, De Castro LM, James AH. Morbidity associated with sickle cell disease in pregnancy. AmJ Obstet Gynecol 2008;199:125 e1-5.
  • 8. Al Jama FE, Gasem T, Burshaid S, Rahman J, Al Suleiman SA, Rahman MS. Pregnancy outcome in patients with homozygous sickle cell disease in a university hospital, Eastern Saudi Arabia. Arch Gynecol Obstet 2009;280:793-7.
  • 9. Diallo D, Tchernia G. Sickle cell disease in Africa. Current opinion in hematology. 2002;9:111-6. 10. Altay Ç. Abnormal Hemoglobins in Turkey. Turk J Haematol. 2002;19:63–74.
  • 11. Sağlık Bakanlığı Riskli Gebelikler Yönetim Rehberi; 2014.
  • 12. Asnani MR, McCaw-Binns AM, Reid ME. Excess risk of maternal death from sickle cell disease in Jamaica: 1998-2007. PloS one. 2011;6:e26281.
  • 13. Boulet SL, Okoroh EM, Azonobi I, Grant A, Craig Hooper W. Sickle cell disease in pregnancy: maternal complications in a Medicaid-enrolled population. Maternal and child health journal. 2013;17:200-7.
  • 14. el-Shafei AM, Sandhu AK, Dhaliwal JK. Maternal mortality in Bahrain with special reference to sickle cell disease. Australian New ZealJ Obstet Gynecol 1988;28:41-4.
  • 15. Pintova S, Cohen HW, Billett HH. Sickle cell trait: is there an increased VTE risk in pregnancy and the postpartum? PloS one. 2013;8:e64141.
  • 16. Koh MB, Lao ZT, Rhodes E. Managing haematological disorders during pregnancy. Best Prac Res Clin Obstet Gynecol 2013;27:855-65.
  • 17. Reducing the Risk of Thrombosis and Embolism during Pregnancy and the Puerperium (Green-top 37a). Royal college of medicine guideline 2009.
  • 18. Zia S, Rafique M. Comparison of pregnancy outcomes in women with sickle cell disease and trait. JPMA 2013;63:743-6.
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Raziye Keskin Kurt This is me

Arif Güngören This is me

Ali Ulvi Hakverdi This is me

Kenan Serdar Dolapçıoğlu This is me

Dilek Benk Silfeler This is me

Oya Soylu Karapinar This is me

Atilla Karateke This is me

Publication Date April 1, 2014
Published in Issue Year 2014 Volume: 11 Issue: 2

Cite

Vancouver Keskin Kurt R, Güngören A, Hakverdi AU, Dolapçıoğlu KS, Silfeler DB, Soylu Karapinar O, Karateke A. Orak Hücre Anemisi Olan Gebelerde Perinatal ve Maternal Sonuçlar. JGON. 2014;11(2):33-6.