Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes

Year 2020, Volume: 17 Issue: 1, 262 - 265, 31.03.2020

Alparslan Deniz

Abstract

Objective: This study aims to compare the placental alpha microglobulin-1 (PAMG-1) versus insulin-like growth factor binding protein-1 (IGFBP-1) and nitrazine test for the prediction of rupture of membranes (ROM) in women with known and unknown rupture status.
Methods: This prospective study included a total of 90 patients with known and unknown rupture status who were between 24 and 42 weeks of gestation at Okmeydani Training and Research Hospital, Obstetrics and Gynecology outpatient clinics between September 2006 and May 2007. In patients with known rupture status, diagnosis was based on conventional methods, while the PAMG-1, IGFBP-1, and nitrazine tests were performed in patients with unknown rupture status. The patients were divided into three groups as Group 1 (n=30) without any signs of ROM, Group 2 (n=30) with typical signs of spontaneous ROM, and Group 3 (n=30) with symptoms suggestive of ROM who were unable to be diagnosed using conventional methods. Performance metrics of PAMG-1, IGFBP-1, and nitrazine tests were calculated and compared.
Results: Of the patients, the mean age was 28. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of nitrazine was 94.4%, 50.0%, 73.9%, and 85.7%, respectively. These values were 77.8%, 83.3%, 87.5%, and 71.4% for the IGFBP-1, respectively and 94.4%, 100%, 100%, and 92.3% for the PAMG-1, respectively. Accordingly, the PAMG-1 showed the highest diagnostic value in both the overall population and those with an equivocal status of ROM.
Conclusion: Our study results suggest that IGFBP-1 and nitrazine are not suitable for the diagnosis of unknown ROM and the PAMG-1 is a more accurate biomarker in patients with both known and unknown status of ROM. In addition, it is a simple and effective tool for the diagnosis of ROM in patients with unknown rupture status.

Keywords

premature rupture of membranes, placental alpha microglobulin-1, insulin- like growth factor binding protein-1, nitrazine

Project Number

Okmeydanı Eğitim ve Araştırma Hastanesi -Uzmanlık Tezi 2007-1a

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