Prematürenin Geçici Klitoromegalisi: Üç Olgunun Değerlendirilmesi

Year 2020, Volume: 17 Issue: 2, 402 - 404, 25.06.2020

Zeynep Uzan Tatlı , Nihal Hatipoğlu , Selim Kurtoglu

https://doi.org/10.38136/jgon.673453

Abstract

Yenidoğan prematüre bebeklerde anneden veya bebeğin kendisinden kaynaklanabilen çeşitli nedenlerle klitoromegali saptanabilmektedir. Yenidoğan bebeklerde klitoromegali varlığında, konjenital adrenal hiperplazi başta olmak üzere, adrenal kitleler, klitoris yerleşimli yer kaplayıcı lezyonlar araştırılmalıdır. Bu sebeplerin dışında yenidoğan prematüre bebeklerde geçici, selim klitoromegali gelişimi tanımlanmıştır. Prematüreliğe bağlı yağ dokusu azlığı, fetal adrenal korteks aktivitesi gibi nedenlerle açıklanmaya çalışılan bu durum bazen hastanın gereksiz tedaviler almasına bile neden olabilir. Dolayısıyla, prematüre bebeklerde görülen klitoromegali dikkatle ele alınması gereken bir bulgudur.

Keywords

klitoromegali, prematüre, adrenal bez, yenidoğan

References

• Referans1: Litwin A, Aitkin I, Merlob P. Clitoral length assessment in newborn infants of 30 to 41 weeks gestational age. Eur J Obstet Gynecol Reprod Biol. 1991 Feb 25;38(3):209-12. PubMed PMID: 2007446.
• Referans2: Jarrett OO, Ayoola OO, Jonsson B, Albertsson-Wikland K, Ritzen M. Country-based reference values and international comparisons of clitoral size in healthy Nigerian newborn infants. Acta Paediatr. 2015 Dec;104(12):1286-90. doi:10.1111/apa.13219. PubMed PMID: 26524391.
• Referans3: Oberfield SE, Mondok A, Shahrivar F, Klein JF, Levine LS. Clitoral size in full-term infants. Am J Perinatol. 1989 Oct;6(4):453-4. PubMed PMID: 2789544.
• Referans4: Akçurin S, Türkkahraman D, Kim WY, Durmaz E, Shin JG, Lee SJ. A Novel NullMutation in P450 Aromatase Gene (CYP19A1) Associated with Development of Hypoplastic Ovaries in Humans. J Clin Res Pediatr Endocrinol. 2016 Jun 5;8(2):205-10. doi: 10.4274/jcrpe.2761. Epub 2016 Apr 18. PubMed PMID: 27086564; PubMed Central PMCID: PMC5096477.
• Referans5: Kirk JM, Perry LA, Shand WS, Kirby RS, Besser GM, Savage MO. Female pseudohermaphroditism due to a maternal adrenocortical tumor. J Clin Endocrinol Metab. 1990 May;70(5):1280-4. Review. PubMed PMID: 2186056.
• Referans6: Akçam M, Topaloglu Ak. Extremely immature infant who developed clitoromegaly during the second month of her postnatal life probably due to frequent whole blood transfusion from an adult male. Pediatr Int. 2003 Jun;45(3):347-8. PubMed PMID: 12828595.
• Refarans7: Mondal R, Chatterjee K, Samanta M, Hazra A, Ray S, Sabui TK, Banerjee B, DasvS, Roychowdhury D, Biswas R. Clitoral Length and Anogenital Ratio in Indian Newborn Girls. Indian Pediatr. 2016 Apr;53(4):299-303. PubMed PMID: 27156541.
• Referans8: Singh A, Chitragar SS, Dadhwal V, Jindal VL, Sharma AK, Suri V, Mittal S. Vascular hamartoma: an unusual cause of clitoromegaly in an 18-year-old patient. J Low Genit Tract Dis. 2012 Jul;16(3):325-7. doi: 10.1097/LGT.0b013e3182422c54. PubMed PMID: 22453757.
• Referans9: Schober MS, Hendrickson BW, Alpert SA. Spontaneous clitoral hood epidermal inclusion cyst mimicking clitoromegaly in a pediatric patient. Urology. 2014 Jul;84(1):206-8. doi: 10.1016/j.urology.2014.03.008. Epub 2014 Apr 29. PubMed PMID: 24793002.
• Referans10: Karabouta Z, Rousso I, Athanassiadou-Piperopoulou F. Clitoromegaly as first presentation of a neurocutaneous syndrome in a 3-year-old girl. Clin Case Rep. 2015 Sep;3(9):767-8. doi: 10.1002/ccr3.320. Epub 2015 Jul 29. PubMed PMID: 26401284; PubMed Central PMCID: PMC4574795.
• Referans11: Nayyar S, Liaqat N, Sultan N, Dar SH. Cavernous haemangioma mimicking as clitoral hypertrophy. Afr J Paediatr Surg. 2014 Jan-Mar;11(1):65-6. doi: 10.4103/0189 6725.129238. PubMed PMID: 24647298.
• Referans12: Ishimoto H, Jaffe RB. Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit. Endocr Rev. 2011 Jun;32(3):317-55. doi: 10.1210/er.2010-0001. Epub 2010 Nov 4. Review. PubMed PMID: 21051591; PubMed Central PMCID: PMC3365797.
• Referans13: Couch R, Girgis R. Postnatal virilization mimicking 21-hydroxylase deficiency in 3 very premature infants. Pediatrics. 2012 May;129(5):e1364-7. doi: 10.1542/peds.2011-1895. Epub 2012 Apr 2. PubMed PMID: 22473363.
• Referans14: KUTLU, Hatice Alev; AKBIYIK, Fatih. Clitoral length in female newborns: a new approach to the assessment of clitoromegaly. Turkish Journal of Medical Sciences, 2011, 41.3: 495-499.