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Comparison of Pregnancy Outcomes Among Pregnant Women with Epilepsy Diagnosis and Perinatal Outcomes with Non-Epileptic Pregnant Women Without Epilepsy Diagnosis: A Retrospective Study

Year 2024, Volume: 21 Issue: 2, 62 - 68, 30.06.2024
https://doi.org/10.38136/jgon.1142285

Abstract

Introduction: Research; This study was planned retrospectively in order to compare the problems experienced by women diagnosed with epilepsy during pregnancy, seizure status, drug use, and maternal and fetal outcomes with non-epileptic pregnant women. Materials and Methods: The study was carried out retrospectively on the records of pregnant women with and without epilepsy. The total sample group in the study consisted of 445 pregnant women (49 in the study group, 396 in the control group). The data of the study were collected by examining all birth records in the Obstetrics and Gynecology Clinic of a Medical Faculty Hospital in Konya between March 2015 and February 2020. The data of the study were recorded using the data collection form. Results: No statistically significant difference was found between the epileptic and non-epileptic pregnant women included in the study in terms of age, gravida and parity (p>0.05). It was determined that epileptic pregnants made their first doctor visits later in pregnancy, while the total number of antenatal visits was lower (p<0.05). It has been determined that the antenatal and postnatal complications of epileptic pregnant women are at low levels, the drug is used at a high rate, and although there is a small increase in seizures with pregnancy, this is not statistically significant. Conclusion: Epileptic pregnant women do not have worse antenatal, natal and postnatal outcomes compared to non-epileptic pregnant women. The importance of antenatal follow-up should be explained to epileptic pregnant women starting from the preconceptional period, and their awareness should be increased about the importance of using drugs that can prevent epileptic seizures and closely following dose settings.

References

  • Beghi E. The Epidemiology of Epilepsy. Neuroepidemiology. 2020;54(2):185–91.
  • Fiest KM, Sauro KM, Wiebe S, Patten SB, Dykeman J, Pringsheim T, et al. Prevalence and incidence of epilepsy A systematic review and meta-analysis of international studies. Neurology. 2017;(88):296–303.
  • Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197–223.
  • Pennell PB, French JA, Harden CL, Davis A, Bagiella E, Andreopoulos E, et al. Fertility and Birth Outcomes in Women With Epilepsy Seeking Pregnancy. JAMA Neurol. 2018 Aug 1;75(8):962.
  • Soontornpun A, Choovanichvong T, Tongsong T. Pregnancy outcomes among women with epilepsy : A retrospective cohort study. Epilepsy Behav. 2018;82:52–6.
  • Razaz N, Tomson T, Wikström A-K, Cnattingius S. Association Between Pregnancy and Perinatal Outcomes Among Women With Epilepsy. JAMA Neurol. 2017;74(8):983–91.
  • Erişgin Z, Ayyıldız M. GEBELİK ve EPİLEPSİ. Düzce Tıp Fakültesi Derg. 2016;18(1):35–41.
  • Çim N, Tolunay HE, Karaman E, Elçi GG, Aksin Ş. Epilepsinin Gebelik Sonuçları Üzerine Etkisi. Van Tıp Derg. 2018;25(2):180–7
  • Pak AT. Gebelerde Epilepsi Tedavisi Aygül. Düzce Üniversitesi Sağlık Bilim Enstitüsü Derg. 2020;10(1):111–5.
  • Tekin B. Epilepsi , Gebelik ve Antiepileptik İlaçlar. Epilepsi. 2018;24(Suppl.1):41–3.
  • Bayrak M, Bozdağ H, Karadağ C, Günay T, Göynümer G. Epilepsi Tanılı Gebelerde Obstetrik ve Perinatal Sonuçların Retrospektif Analizi. İKSST Derg. 2014;6(3):127–32.
  • Borthen I, Eide MG, Veiby G, Daltveit AK, Gilhus NE. Complications during pregnancy in women with epilepsy: population-based cohort study. BJOG [Internet]. 2009 Dec;116(13):1736–42.
  • MacDonald SC, Bateman BT, McElrath TF, Hernández-Díaz S. Mortality and Morbidity During Delivery Hospitalization Among Pregnant Women With Epilepsy in the United States. JAMA Neurol [Internet]. 2015 Sep;72(9):981–8.
  • Soydinç HE, Turgut A, Sak ME, Özler A, Evsen, Mehmet Başaranoğlu S, Yalınkaya A, et al. Pregnancy and epilepsy: a retrospective analysis of 46 patients, and comparison of perinatal outcomes with healthy pregnant women. Perinat J. 2013;21(1).
  • Güler SK, Kahvecioğlu D. Malformations and Neonatal Problems in Babies of Mothers with Epilepsy. What are the Possible Problems in Women with Epilepsy During Pregnancy? Epilepsi. 2019;25(3):147–54.
  • Kazandı M, Ulusoy D, Mermer TK, İtil İM. EPİLEPSİ TANISI ALMIŞ KADINLARDA GEBELİK SONUÇLARININ RETROSPEKTİF ANALİZİ. J Turkish Soc Obstet Gynecol. 2010;7(3):212–7.
  • Katz O, Levy A, Wiznitzer A, Sheiner E. Pregnancy and perinatal outcome in epileptic women: A population-based study. J Matern Neonatal Med. 2006;19(1):21–5.
  • Özdemir S, Balc O, Tazegül A, Said M, Demir A, Yüksekkaya HA. Assessment of Maternal and Perinatal Outcomes in Pregnancies Complicated by Epilepsy. 2010;8–13.
  • Artama M, Braumann J, Raitanen J, Uotila J, Gissler M, Isojärvi J, et al. Women treated for epilepsy during pregnancy: outcomes from a nationwide population-based cohort study. Acta Obstet Gynecol Scand. 2017;96(7):812–20.
  • Jeyrani P, Indumathi S. Maternal outcome in epilepsy complicating pregnancy. Int J Res Heal Sci. 2014;(2):488–93.
  • Gök K, Yılmaz E, Özgül A, Gök NR, Bostanci MS, Özden S. Epilepsy and Pregnancy: Retrospective analysis of 58 cases. Haydarpasa Numune Med J. 2022;62(1).
  • Bayır BRH, Gürsoy G, Tutkavul K, Çetinkaya Y. Pregnancy and Epilepsy: Monitoring and Treating the Seizures. Epilepsi. 2019;25(3):117–22.

Epilepsi Tanılı Gebelerin Gebelik Sonuçları ve Epilepsi Tanısı Olmayan Gebeler ile Perinatal Sonuçların Karşılaştırılması: Retrospektif Araştırma

Year 2024, Volume: 21 Issue: 2, 62 - 68, 30.06.2024
https://doi.org/10.38136/jgon.1142285

Abstract

Amaç: Araştırma; epilepsi tanısı almış kadınların gebelikte yaşadığı sorunlar, nöbet durumları, ilaç kullanım durumları ve epileptik olmayan gebeler ile maternal ve fetal sonuçlarının karşılaştırılması amacıyla retrospektif olarak planlanmıştır. Gereç ve Yöntem: Araştırma, epilepsi tanısı olan ve epilepsi tanısı olmayan gebelerin kayıtları üzerinde retrospektif olarak gerçekleştirilmiştir. Araştırmada toplam örneklem grubunu 445 gebe (çalışma grubu 49, kontrol grubu 396) oluşturmuştur. Araştırmanın verileri Mart 2015-Şubat 2020 tarihleri arasında Konya ilinde yer alan bir Tıp Fakültesi Hastanesinin Kadın Doğum Kliniğindeki tüm doğum kayıtları incelenerek toplanmıştır. Araştırmanın verileri veri toplama formu kullanılarak kayıt altına alınmıştır. Bulgular: Çalışmaya dahil edilen epileptik olan ve olmayan gebeler arasında yaş, gravida ve parite açısından istatistiksel olarak anlamlı bir farklılık bulunmamıştır (p>0.05). Epileptik gebelerin gebelikteki ilk doktor ziyaretlerini daha geç yaparken, toplam antenatal ziyaret sayılarını daha az olduğu saptanmıştır (p<0.05). Epileptik gebelerin antenatal ve postnatal komplikasyonlarının düşük düzeylerde olduğu, yüksek oranda ilaç kullanıldığı ve gebelikle birlikte nöbetlerde çok az miktarda artış yaşansa da bunun istatistiksel açıdan anlamlı olmadığı tespit edilmiştir. Sonuç: Epileptik gebeler epileptik olmayan gebeler ile karşılaştırıldığında daha kötü antenatal, natal ve postnatal sonuçları bulunmamaktadır. Epileptik gebelere prekonsepsiyonel dönemden başlayarak antenatal izlemin önemi anlatılmalı, epileptik nöbetleri engelleyebilecek ilaç kullanımının, doz ayarlarının yakından takip edilmesinin önemi konusunda farkındalıkları artırılmalıdır.

References

  • Beghi E. The Epidemiology of Epilepsy. Neuroepidemiology. 2020;54(2):185–91.
  • Fiest KM, Sauro KM, Wiebe S, Patten SB, Dykeman J, Pringsheim T, et al. Prevalence and incidence of epilepsy A systematic review and meta-analysis of international studies. Neurology. 2017;(88):296–303.
  • Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197–223.
  • Pennell PB, French JA, Harden CL, Davis A, Bagiella E, Andreopoulos E, et al. Fertility and Birth Outcomes in Women With Epilepsy Seeking Pregnancy. JAMA Neurol. 2018 Aug 1;75(8):962.
  • Soontornpun A, Choovanichvong T, Tongsong T. Pregnancy outcomes among women with epilepsy : A retrospective cohort study. Epilepsy Behav. 2018;82:52–6.
  • Razaz N, Tomson T, Wikström A-K, Cnattingius S. Association Between Pregnancy and Perinatal Outcomes Among Women With Epilepsy. JAMA Neurol. 2017;74(8):983–91.
  • Erişgin Z, Ayyıldız M. GEBELİK ve EPİLEPSİ. Düzce Tıp Fakültesi Derg. 2016;18(1):35–41.
  • Çim N, Tolunay HE, Karaman E, Elçi GG, Aksin Ş. Epilepsinin Gebelik Sonuçları Üzerine Etkisi. Van Tıp Derg. 2018;25(2):180–7
  • Pak AT. Gebelerde Epilepsi Tedavisi Aygül. Düzce Üniversitesi Sağlık Bilim Enstitüsü Derg. 2020;10(1):111–5.
  • Tekin B. Epilepsi , Gebelik ve Antiepileptik İlaçlar. Epilepsi. 2018;24(Suppl.1):41–3.
  • Bayrak M, Bozdağ H, Karadağ C, Günay T, Göynümer G. Epilepsi Tanılı Gebelerde Obstetrik ve Perinatal Sonuçların Retrospektif Analizi. İKSST Derg. 2014;6(3):127–32.
  • Borthen I, Eide MG, Veiby G, Daltveit AK, Gilhus NE. Complications during pregnancy in women with epilepsy: population-based cohort study. BJOG [Internet]. 2009 Dec;116(13):1736–42.
  • MacDonald SC, Bateman BT, McElrath TF, Hernández-Díaz S. Mortality and Morbidity During Delivery Hospitalization Among Pregnant Women With Epilepsy in the United States. JAMA Neurol [Internet]. 2015 Sep;72(9):981–8.
  • Soydinç HE, Turgut A, Sak ME, Özler A, Evsen, Mehmet Başaranoğlu S, Yalınkaya A, et al. Pregnancy and epilepsy: a retrospective analysis of 46 patients, and comparison of perinatal outcomes with healthy pregnant women. Perinat J. 2013;21(1).
  • Güler SK, Kahvecioğlu D. Malformations and Neonatal Problems in Babies of Mothers with Epilepsy. What are the Possible Problems in Women with Epilepsy During Pregnancy? Epilepsi. 2019;25(3):147–54.
  • Kazandı M, Ulusoy D, Mermer TK, İtil İM. EPİLEPSİ TANISI ALMIŞ KADINLARDA GEBELİK SONUÇLARININ RETROSPEKTİF ANALİZİ. J Turkish Soc Obstet Gynecol. 2010;7(3):212–7.
  • Katz O, Levy A, Wiznitzer A, Sheiner E. Pregnancy and perinatal outcome in epileptic women: A population-based study. J Matern Neonatal Med. 2006;19(1):21–5.
  • Özdemir S, Balc O, Tazegül A, Said M, Demir A, Yüksekkaya HA. Assessment of Maternal and Perinatal Outcomes in Pregnancies Complicated by Epilepsy. 2010;8–13.
  • Artama M, Braumann J, Raitanen J, Uotila J, Gissler M, Isojärvi J, et al. Women treated for epilepsy during pregnancy: outcomes from a nationwide population-based cohort study. Acta Obstet Gynecol Scand. 2017;96(7):812–20.
  • Jeyrani P, Indumathi S. Maternal outcome in epilepsy complicating pregnancy. Int J Res Heal Sci. 2014;(2):488–93.
  • Gök K, Yılmaz E, Özgül A, Gök NR, Bostanci MS, Özden S. Epilepsy and Pregnancy: Retrospective analysis of 58 cases. Haydarpasa Numune Med J. 2022;62(1).
  • Bayır BRH, Gürsoy G, Tutkavul K, Çetinkaya Y. Pregnancy and Epilepsy: Monitoring and Treating the Seizures. Epilepsi. 2019;25(3):117–22.
There are 22 citations in total.

Details

Primary Language Turkish
Subjects Obstetrics and Gynaecology
Journal Section Research Articles
Authors

Fatma Bay 0000-0001-8840-1279

Elifsena Canan Alp 0000-0002-1956-1014

Ayşe Nur Ataş 0000-0003-3096-3599

Publication Date June 30, 2024
Submission Date July 7, 2022
Acceptance Date February 7, 2024
Published in Issue Year 2024 Volume: 21 Issue: 2

Cite

Vancouver Bay F, Alp EC, Ataş AN. Epilepsi Tanılı Gebelerin Gebelik Sonuçları ve Epilepsi Tanısı Olmayan Gebeler ile Perinatal Sonuçların Karşılaştırılması: Retrospektif Araştırma. JGON. 2024;21(2):62-8.