Polikistik Over Sendromuyla Baş Etme Yolları: Hayıt Otu Tedavisi Üzerine Bir Derleme

Yıl 2024, Cilt: 3 Sayı: 1, 36 - 58, 30.04.2024

Şeyma Demir , Yasemin Erkal Aksoy

Öz

Polikistik over sendromunu tedavi etmek için bugüne kadar çok çeşitli doğal veya tamamlayıcı ilaçlar kullanılmaktadır. Sıhhi kuruluşların, kadınlara yardımcı olmak ve kanıtlara dayalı olarak alternatif tedavi konusunda doğru kararı verebilmek için eksiksiz ve uygun ayrıntılara ihtiyaçları vardır. Bu çalışmanın amacı Polikistik over sendromuna yönelik şifalı bir bitki olan hayıt otuyla gerçekleştirilen tedavileri tanıtmak ve bu rahatsızlığa ilişkin klinik araştırmaları özetlemektir. Polikistik over sendromu tedavisinde hayıt otunun olumlu etkileri üzerine yapılan çalışmalarda, menstrual siklusta düzelme, hirsutizm ve akne belirtilerinin azalması, ruhsal sağlığın iyileşmesi gibi sonuçlar gözlemlenmiştir. Fitoöstrojenik bir bitki olduğu için östrojen salgısını artırabilir. Ayrıca, hayıt otunun folikül boyutlarını ve sayılarını artırabildiği, testosteron seviyelerini düşürebileceği ve oral kontraseptif hapların alternatifi olabileceği bulgularına da rastlanmıştır. Bu bulgular, Polikistik over sendromu tedavisinde hayıt otunun potansiyel etkilerini anlamamıza yardımcı olmaktadır. Bu nedenle Polikistik over sendromu tedavisinde hayıt otu düşünülebilir; ancak olası yan etkileri hakkında daha fazla ayrıntı elde etmek için daha fazla araştırmaya ihtiyaç vardır.

Anahtar Kelimeler

hayıt otu, polikistik over sendromu, kadın

Destekleyen Kurum

Herhangi bir finansal destek alınmamıştır.

Teşekkür

Hayıt otu ve polikistik over sendromu ile ilgili çalışma yapan yazarlara teşekkür ederiz.

Ways to Cope with Polycystic Ovary Syndrome: A Review on Vitex Agnus Castus L. Treatment

Öz

Polycystic ovary syndrome is currently treated with a wide range of natural or complementary medicines. Medical organizations need complete and appropriate details to help women and make the right decision about alternative treatment based on evidence. The aim of this study is to introduce treatments for polycystic ovary syndrome with the Vitex Agnus Castus L. herb and to summarize the clinical research on this condition. Studies of the beneficial effects of Vitex Agnus Castus L. in the treatment of polycystic ovary syndrome have shown results such as improvement in menstrual cycles, reduction in hirsutism and acne symptoms, and improvement in mental health. As a phytoestrogenic plant, it can increase estrogen secretion. In addition, Vitex Agnus Castus L. has been found to increase the size and number of follicles, reduce testosterone levels and be an alternative to oral contraceptives. These findings help us to understand the potential effects of Vitex Agnus Castus L. in the treatment of polycystic ovary syndrome. Therefore, Vitex Agnus Castus L. herb can be considered in the treatment of polycystic ovary syndrome; however, more research is needed to obtain more details about possible side effects.

Anahtar Kelimeler

Polycystic ovary syndrome, woman, vitex agnus castus l.

Kaynakça

• 1. Macruz CF, Lima SMRR. Polycystic ovary syndrome and abdominal fat: is there a relationship? Rev Assoc Med Bras [Internet]. 2023;69(11). Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302023001100618&tlng=en
• 2. Goswami PK, Khale A, Ogale S. Natural Remedies for Polycystic Ovarian Syndrome (PCOS) : A Review. International Journal of Pharmaceutical and Phytopharmacological Research [Internet]. 2012;1(6):396–402. Available from: www.eijppr.com
• 3. Lim SS, Davies MJ, Norman RJ, Moran LJ. Overweight, obesity and central obesity in women with polycystic ovary syndrome: A systematic review and meta-analysis. Hum Reprod Update. 2012 Nov;18(6):618–37.
• 4. Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016 Jul;106(1):6–15.
• 5. Çınar M, Eryılmaz ÖG. Experimental models of polycystic ovary syndrome. Vol. 31, Medeniyet Medical Journal. Logos Medical Publishing; 2016. p. 53–7.
• 6. Lu KT, Ho YC, Chang CL, Lan KC, Wu CC, Su YT. Evaluation of Bodily Pain Associated with Polycystic Ovary Syndrome: A Review of Health-Related Quality of Life and Potential Risk Factors. Biomedicines. 2022 Dec 1;10(12):3197.
• 7. Khamoshina MB, Artemenko YS, Bayramova AA, Ryabova VA, Orazov MR. Polycystic ovary syndrome and obesity: A modern paradigm. RUDN Journal of Medicine. 2022;26(4):382-395.
• 8. Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018 Aug;110(3):364-379.
• 9. Morshedi T, Salehi M, Farzad V, Hassani F, Shakibazadeh E. The status of relationship between coping strategies and quality of life in women with polycystic ovary syndrome. J Educ Health Promot. 2021 Jan 1;10(1):185.
• 10. Zhang D, Gao J, Qin H, Chang H, Wu X. Phenotypic features and fertility outcomes of women with polycystic ovary syndrome: The effect of quality of life. Journal of Obstetrics and Gynaecology Research [Internet]. 2021 Jan 14;47(1):233–42. Available from: https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.14478
• 11. Arentz S, Smith CA, Abbott J, Bensoussan A. Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis. BMC Complement Altern Med. 2017 Nov 25;17(1).
• 12. Stener-Victorin E, Holm G, Janson PO, Gustafson D, Waern M. Acupuncture and physical exercise for affective symptoms and health-related quality of life in polycystic ovary syndrome: secondary analysis from a randomized controlled trial. BMC Complement Altern Med. 2013 Dec 13;13(1):131.
• 13. Amini L, Candidate PD, Tehranian N, Movahedin M, Tehrani R, Ziaee S. Systematic review Antioxidants and management of polycystic ovary syndrome in Iran: A systematic review of clinical trials. Iran J Reprod Med. 2015;13(1):1–8.
• 14. Dugoua JJ, Seely D, Perri D, Koren G, Mills E. Safety and efficacy of chastetree (Vitex agnus-castus) during pregnancy and lactation. Can J Clin Pharmacol. 2008;15(1):e74-9.
• 15. Ho SHY, Singh M, Holloway AC, Crankshaw DJ. The Effects of Commercial Preparations of Herbal Supplements Commonly Used by Women on the Biotransformation of Fluorogenic Substrates by Human Cytochromes P450. Phytotherapy Research. 2011 Jul 7;25(7):983–9.
• 16. Ono M, Eguchi K, Konoshita M, Furusawa C, Sakamoto J, Yasuda S, et al. A New Diterpenoid Glucoside and Two New Diterpenoids from the Fruit of Vitex agnus-castus. Chem Pharm Bull (Tokyo). 2011;59(3):392–6.
• 17. Niroumand M, Heydarpour F, Farzaei M. Pharmacological and therapeutic effects of Vitex agnus-castus L.: A review. Pharmacogn Rev. 2018;12(23):103.
• 18. Souto EB, Durazzo A, Nazhand A, Lucarini M, Zaccardelli M, Souto SB, et al. Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives. Forests. 2020 Jul 16;11(7):761.
• 19. Bello MO, Zaki AA, Aloko S, Fasinu PS, Bello EO, Ajao UL, et al. The genus Vitex: An overview of iridoids as chemotaxonomic marker. Beni Suef Univ J Basic Appl Sci. 2018 Dec;7(4):414–9.
• 20. Boujbiha MA, Chahdoura H, Adouni K, Ziani BEC, Snoussi M, Chakroun Y, et al. Wild Vitex agnus-castus L.: Phytochemical Characterization, Acute Toxicity, and Bioactive Properties. Molecules. 2023 Jul 1;28(13).
• 21. Kırmızıbekmez H, Demir D. Iridoid Glycosides and Phenolic Compounds from the Flowers of Vitex agnus‐castus. Helv Chim Acta [Internet]. 2016 Jul 15;99(7):518–22. Available from: https://onlinelibrary.wiley.com/doi/10.1002/hlca.201600022
• 22. Kuruüzüm-Uz A, Ströch K, Demirezer LÖ, Zeeck A. Glucosides from Vitex agnus-castus. Phytochemistry. 2003 Aug;63(8):959–64.
• 23. Chen SN, Friesen JB, Webster D, Nikolic D, van Breemen RB, Wang ZJ, et al. Phytoconstituents from Vitex agnus-castus fruits. Fitoterapia [Internet]. 2011 Jun;82(4):528–33. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0367326X10003175
• 24. Hamza A, AlBishri W, Alfaris M. Effect of Vitex agnus-castus plant extract on polycystic ovary syndrome complications in experimental rat model. Asian Pacific Journal of Reproduction [Internet]. 2019 Mar 1;8(2):63. Available from: http://www.apjr.net/text.asp?2019/8/2/63/254647
• 25. Das N, Salgueiro ACF, Choudhury DR, Mandal SK, Logesh R, Hassan MdM, et al. Traditional uses, phytochemistry, and pharmacology of genus Vitex (Lamiaceae). Phytotherapy Research [Internet]. 2022 Feb 23;36(2):571–671. Available from: https://onlinelibrary.wiley.com/doi/10.1002/ptr.7330
• 26. Baytop T. Therapy with Medicinal Plants in Turkey Past and Present . Vol. 2. İstanbul: Nobel Tıp Kitabevi; 1999. 169 p.
• 27. Uysal I, Gucel S, Tütenocaklı T, Öztürk M. Studies on the medicinal plants of Ayvacık-Çanakkale in Turkey. PakJBot. 2012 Mar;239–44.
• 28. American Botanical Council. The Commission E monographs. [Internet]. 2020 [cited 2024 Apr 21]. Available from: http://cms.herbalgram.org/commissione/Monographs/Monograph0185.html Erişim tarihi:21.04.2024
• 29. U.S. Food & Drug Administration (FDA). Inxight Drugs VITEX AGNUS-CASTUS WHOLE [Internet]. [cited 2024 Apr 22]. Available from: https://drugs.ncats.io/substance/9HDT03PZ0N
• 30. U.S. Food & Drug Administration (FDA). Inxight Drugs VITEX AGNUS-CASTUS LEAF [Internet]. [cited 2024 Apr 22]. Available from: https://drugs.ncats.io/substance/W4U9Y3Q5SR
• 31. Türkiye İlaç ve Tıbbi Cihaz Kurumu (TİTCK). Geleneksel Bitkisel Tıbbi Ürünler Ruhsatlandırma Yönetmeliği. Resmi Gazete [Internet]. 2023 Feb 3 [cited 2024 Apr 21]; Available from: https://www.resmigazete.gov.tr/eskiler/2023/02/20230203-5.htm Erişim tarihi:21.04.2024
• 32. Tarım ve Orman Bakanlığı. Bitki Listesi [Internet]. 2024 [cited 2024 Apr 21]. p. 69. Available from: https://www.tarimorman.gov.tr/konu/957/bitki-listesi
• 33. Okuyama E, Fujimori S, Yamazaki M, Deyama T. Pharmacologically Active Components of Viticis Fructus (Vitex rotundifolia). II. The Components Having Analgesic Effects. Chem Pharm Bull (Tokyo). 1998;46(4):655–62.
• 34. Ohyama K, Akaike T, Hirobe C, Yamakawa T. Cytotoxicity and Apoptotic Inducibility of Vitex agnus-castus Fruit Extract in Cultured Human Normal and Cancer Cells and Effect on Growth. Biol Pharm Bull. 2003;26(1):10–8.
• 35. Saberi M, Rezvanizadeh A, Bakhtiarian A. The antiepileptic activity of Vitex agnus castus extract on amygdala kindled seizures in male rats. Neurosci Lett. 2008 Aug;441(2):193–6.
• 36. Webster DE, He Y, Chen SN, Pauli GF, Farnsworth NR, Wang ZJ. Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. Biochem Pharmacol. 2011 Jan;81(1):170–7.
• 37. Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D. Chaste tree (Vitex agnus-castus) – Pharmacology and clinical indications. Phytomedicine. 2003 Jan;10(4):348–57.
• 38. van Die M, Burger H, Teede H, Bone K. Vitex agnus-castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials. Planta Med. 2012 Nov 7;79(07):562–75.
• 39. Saul S. Effects of vitex agnes castus on hormonal imbalances in Polycystic Ovary Syndrome. Int J Basic Clin Pharmacol. 2017 Jul 22;6(8):2051.
• 40. Rani A, Sharma A. The genus Vitex: A review. Pharmacogn Rev. 2013;7(14):188.
• 41. Niroumand M, Heydarpour F, Farzaei M. Pharmacological and therapeutic effects of Vitex agnus-castus L.: A review. Pharmacogn Rev. 2018;12(23):103.
• 42. Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus. Drug Saf. 2005;28(4):319–32.
• 43. Barnes J, Anderson LA, Philipson JD. Herbal Medicine . 3rd Edition. London: Pharmaceutical Press; 2007. 1–23 p.
• 44. Tjeerdsma AM, van Hunsel FPAM, van de Koppel S, Ekhart C, Vitalone A, Woerdenbag HJ. Analysis of Safety Concerns on Herbal Products with Assumed Phytoestrogenic Activity. Pharmaceuticals. 2023 Aug 10;16(8):1137.
• 45. Najib FS, Poordast T, Mahmudi MS, Shiravani Z, Namazi N, Omrani GR. Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety. J Pharmacopuncture. 2022 Jun 30;25(2):106–13.
• 46. Nice. Herbals and breastfeeding. The Journal of Modern Pharmacy, 9(2), 16-19. 2002;9(2):16–9.
• 47. Zapantis A, Steinberg JG, Schilit L. Use of Herbals as Galactagogues. J Pharm Pract. 2012 Apr 5;25(2):222–31.
• 48. WHO. Fructus Agni Casti. WHO monographs on selected medicinal plants. . 2009;9–29.
• 49. Daniele C, Coon JT, Pittler MH, Ernst E. A Systematic Review of Adverse Events. Vol. 28, Drug Safety. 2005.
• 50. Mirghafourvand M, Mohammad-Alizadeh-Charandabi S, Ahmadpour P, Javadzadeh Y. Effects of Vitex agnus and Flaxseed on cyclic mastalgia: A randomized controlled trial. Complement Ther Med. 2016 Feb;24:90–5.
• 51. Antoine E, Chirila S, Teodorescu C. A Patented Blend Consisting of a Combination of Vitex agnus-castus Extract, Lepidium meyenii (Maca) Extract and Active Folate, a Nutritional Supplement for Improving Fertility in Women. Maedica (Bucur) [Internet]. 2019 Sep;14(3):274–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/31798745
• 52. Ooi SL, Watts S, McClean R, Pak SC. Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A Systematic Review and Meta-Analysis. J Womens Health. 2020 Feb 1;29(2):262–78.
• 53. Mirmolaei ST, Olfatbakhsh A, Fallahhosseini H. The effect of vitagnus on cyclic breast pain in women of reproductive age . Journal of Babol University of Medical Sciences . 2016 Sep;7–13.
• 54. Irum S, Tasnim N, Luqman S, Irum S. No 1 3 Cite this article as: Irum S, Tasnim N, Luqman Irum S. Comparison of Efficacy of Vitex Agnus Castus Ovitex and Bromocriptine in The Management of Hyperprolactinemia. Vol. 10, J Soc Obstet Gynaecol Pak. 2020.
• 55. Csupor D, Lantos T, Hegyi P, Benkő R, Viola R, Gyöngyi Z, et al. Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials. Complement Ther Med. 2019 Dec;47:102190.
• 56. Sureja VP, Kheni DB, Dubey VP, Kansagra J, Soni ZK, Bhatt SP, et al. Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40TM), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study. Cureus. 2023 Aug 2;
• 57. Artymuk ANV, Zotova ZOA. The effect of the Cyclodynon drug on sexual function in patients with infertility and menstrual disorders. Akush Ginekol (Mosk). 2023 Nov 30;11_2023:158–68.
• 58. Bahman M, Hajimehdipoor H, Bioos S, Hashem-Dabaghian F, Afrakhteh M, Tansaz M. Effect of Aslagh Capsule, a Traditional Compound Herbal Product on Oligomenorrhea in Patients with Polycystic Ovary Syndrome: A Three-Arm, Open-label, Randomized, Controlled Trial. Galen Medical Journal. 2019 Jun 2;8:1261.
• 59. Behmard V, Hadizadeh Talasaz F, Pishvaee M, Khajavian N, Beilandi RR. The effect of Vitex Agnus-Castus pill on follicles number and size in infertile women with polycystic ovary syndrome: A triple-blind placebo randomized clinical trial. Iranian Journal of Obstetrics, Gynecology and Infertility. 2022;25(6):98–106.
• 60. Feyzollahi Z, Mohseni Kouchesfehani H, Jalali H, Eslimi-Esfahani D, Sheikh Hosseini A. Effect of Vitex agnus-castus ethanolic extract on hypothalamic KISS-1 gene expression in a rat model of polycystic ovary syndrome. Avicenna J Phytomed. 2021;11(3):292–301.
• 61. Jelodar G, Askari K. Effect of Vitex agnus-castus fruits hydroalcoholic extract on sex hormones in rat with induced polycystic ovary syndrome (PCOS). Journal of Babol University of Medical Sciences. 2012;16((1)):62–9.
• 62. Shahnazi M, Farshbaf Khalili A, Hamdi K, Ghahremaninasab P. The Effects of Combined Low-Dose Oral Contraceptives and Vitex Agnus on the Improvement of Clinical and Paraclinical Parameters of Polycystic Ovarian Syndrome: A Triple-Blind, Randomized, Controlled Clinical Trial. Iran Red Crescent Med J. 2016 Aug 6;18(12).
• 63. Akad M, Socolov D, Akad F, Covali R, Crauciuc E, Pavaleanu I, et al. Maedica-a Journal of Clinical Medicine Treatments in Patients with Polycystic Ovary Syndrome and Effects on Kisspeptin Serum Levels. Maedica A Journal of Clinical Medicine [Internet]. 2022;17(4):2022. Available from: https://doi.org/10.26574/maedica.2022.17.4.799