Mesenteric panniculitis clinical presentations, management, and outcomes: a single institute experience of 89 patients

Year 2023, Volume: 6 Issue: 6, 1272 - 1276, 29.10.2023

Belma Çevik , Benan Kasapoğlu , Ahmet Yozgat , Murat Kekilli

https://doi.org/10.32322/jhsm.1348835

Cited By: 1

Abstract

Aims: Mesenteric panniculitis is a rare, non-specific, chronic inflammatory disease with a reported incidence of 0.16-3.3% that primarily involves the mesenteric adipose tissue. We aimed to retrospectively analyze the clinical features of patients diagnosed with mesenteric panniculitis.
Methods: We retrospectively analyzed the reports of 941 patients who were examined in the Gastroenterology Clinic of Lokman Hekim Hospital and underwent abdominal computerized tomography (CT) between January 2019 and December 2021.
Results: Among CT scan reports of 941 patients, the diagnosis of mesenteric panniculitis was present in 89 (9.45%) patients (55 male and 34 female). The reasons for obtaining a CT scan in those patients were as follows: severe abdominal pain in 53 (59.6%) patients, weight loss in 16 (17.9%) patients, bloating, distention, and suspicion of sub-ileus in 12 (13.5%) patients, and alterations in abdominal movements (constipation or diarrhea) in 8 (8.9%) patients. Among patients with mesenteric panniculitis, autoimmune diseases were also analyzed 21 were having Hashimoto thyroiditis, 2 were having vitiligo, 2 were having Sjögren’s disease, 1 was having primary biliary cholangiopathy, and 1 was having a diagnosis of celiac disease.
Conclusion: Mesenteric panniculitis is not a very rare disease, diagnosed with mainly CT findings. Although the disease may be associated with some autoimmune diseases and malignancies, the disease outcomes are generally fine. However, there are still many unknown points, especially about the etiology and outcomes of the disease.

Keywords

Mesenteric panniculitis, chronic inflammatory disease, autoimmune diseases, computerized tomography, inflammation

References

• Protin-Catteau L, Thiefin G, Barbe C, et al. Mesenteric panniculitis: review of consecutive abdominal MDCT examinations with a matched-pair analysis. Acta Radiol. 2016;57(12):1438-1444. doi:10.1177/0284185116629829
• Buragina G, Magenta Biasina A, Carrafiello G. Clinical and radiological features of mesenteric panniculitis: a critical overview. Acta Biomed. 2019;90(4):411-422. doi:10.23750/abm.v90i4.7696
• Issa I, Baydoun H. Mesenteric panniculitis: various presentations and treatment regimens. World J Gastroenterol. 2009;15(30):3827-30. doi:10.3748/wjg.15.3827
• Coulier B. Mesenteric panniculitis. Part 2: prevalence and natural course: MDCT prospective study. JBR-BTR. 2011;94(5):241-6. doi:10.5334/jbr-btr.659
• Gogebakan O, Osterhoff MA, Albrecht T. Mesenteric Panniculitis (MP): A frequent coincidental CT finding of debatable clinical significance. Rofo. 2018;190(11):1044-1052. Panniculitis mesenterialis (PM): ein haufiger CT-Zufallsbefund mit umstrittener klinischer Relevanz. doi:10.1055/a-0633-3558
• Nyberg L, Bjork J, Bjorkdahl P, et al. Sclerosing mesenteritis and mesenteric panniculitis-clinical experience and radiological features. BMC Gastroenterol. 2017;17(1):75. doi:10.1186/s12876-017-0632-7
• Scheer F, Spunar P, Wiggermann P, Wissgott C, Andresen R. Mesenteric panniculitis (MP) in CT-a predictor of malignancy? Rofo. 2016;188(10):926-32. Mesenteriale Pannikulitis (MP) im CT-Schnittbild-Ein Pradiktor fur ein Malignom? doi:10.1055/s-0042-110100
• Gunes SO, Akturk Y, Guldogan ES, et al. Association between mesenteric panniculitis and non-neoplastic disorders. Clin Imaging. 2021;79:219-224. doi:10.1016/j.clinimag.2021.05.006
• Wagner C, Dachman A, Ehrenpreis ED. Mesenteric panniculitis, sclerosing mesenteritis and mesenteric lipodystrophy: descriptive review of a rare condition. Clin Colon Rectal Surg. 2022;35(4):342-348. doi:10.1055/s-0042-1743588
• Bansal P, Gilbert EL, Pereira ROL, Virata AR. Mesenteric panniculitis in a patient with new onset dermatomyositis. BMJ Case Rep. 2020;13(1)doi:10.1136/bcr-2019-232183
• Akram S, Pardi DS, Schaffner JA, Smyrk TC. Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients. Clin Gastroenterol Hepatol. 2007;5(5):589-596.doi:10.1016/j.cgh.2007.02.032
• Halligan S, Plumb A, Taylor S. Mesenteric panniculitis: systematic review of cross-sectional imaging findings and risk of subsequent malignancy. Eur Radiol. 2016;26(12):4531-4537. doi:10.1007/s00330-016-4298-2
• Hussain I, Ishrat S, Aravamudan VM, et al. Mesenteric panniculitis does not confer an increased risk for cancers: A systematic review and meta-analysis. Medicine (Baltimore). 2022;101(17):e29143. doi:10.1097/MD.0000000000029143
• Atacan H, Erkut M, Değirmenci F, Akkaya S, Fidan S, Coşar AM. A Single tertiary center 14-year experience with mesenteric panniculitis in Turkey: a retrospective study of 716 patients. Turk J Gastroenterol. 2023;34(2):140-147. doi: 10.5152/tjg.2023.22514.
• Whittle C, Schiappacasse G, Maldonado I et al. Recognizing the ultrasound patterns of mesenteric panniculitis. Ultrasound Q. 2022;38(2):185-190. doi: 10.1097/RUQ.0000000000000549.
• Wang J, Li B. CT findings of idiopathic mesenteric panniculitis and analysis of related factors. Eur J Radiol. 2023;167:111071.
• Sahin A, Artas H, Eroglu Y, et al. An Overlooked potentially treatable disorder: idiopathic mesenteric panniculitis. Med Princ Pract. 2017;26(6):567-572. doi:10.1159/000484605
• Zhao L, Xie D. Mesenteric panniculitis can be diagnosed by examination and cured by comprehensive therapy. Gastroenterol Nurs. 2021;44(4):278-283. doi:10.1097/SGA.0000000000000596
• Alsuhaimi MA, Alshowaiey RA, Alsumaihi AS, Aldhafeeri SM. Mesenteric panniculitis various presentations and management: a single institute ten years, experience. Ann Med Surg (Lond). 2022;80:104203. doi:10.1016/j.amsu.2022.104203