Research Article
BibTex RIS Cite

Distribution of bacteria isolated from urine cultures and resistance pattern of Escherichia coli strains in community-acquired urinary tract infections

Year 2023, Volume: 6 Issue: 6, 1158 - 1161, 29.10.2023
https://doi.org/10.32322/jhsm.1350956

Abstract

Aims: Urinary tract infections are one of the most common among community-acquired infections. Escherichia coli (E. coli) is the most common cause of community-acquired urinary tract infections. In our study, we aimed to determine the correct empirical treatment by determining the resistance profile of E. coli strains isolated from urine cultures in our hospital, thus both establishing an effective treatment and preventing the development of resistance.
Methods: Urine cultures of 3145 patients with urinary tract infection symptoms who applied to the infection and clinical microbiology outpatient clinic of our hospital between January 2019 and December 2019 were analyzed retrospectively. Patients with a history of catheter, a history of urinary operations, a history of hospitalization in the last 15 days, contamination in their cultures, and patients under the age of 18 were excluded from the study, and 422 urine cultures with growth were included in the study.
Results: The mean age of the patients included in the study was 49.8±14.7 years, and the gender distribution consisted of 301 females (71.3%) and 121 males (28.7%). E. coli was isolated in 313 (77.6%) of these cultures. The antibiotic with the highest resistance rate was trimethoprim-sulfametoxazole (34.8%), while the antibiotics with the lowest resistance rates were fosfomycin and imipenem (0.6%).
Conclusions: Considering that the resistance profiles of microorganisms are different from each other on the basis of country, region, and city, revealing regional resistance patterns can make an important contribution to both establishing effective treatment and preventing the development of antibiotic resistance.

References

  • Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103-e120.
  • Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med. 2002;113(1):5-13.
  • Demirtürk N, Demirdal T, Eldemir H, İnce R, Altındiş M. İdrar örneklerinden izole edilen bakterilerin antibiyotiklere duyarlılıkları. Türk Mikrobiyol Cem Derg. 2005;35(2):103-106.
  • Foxman B. Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden. Infect Dis Clin. 2014;28(1):1-13.
  • Griebling TL. Urologic diseases in America project: trends in resource use for urinary tract infections in women. J Urol. 2005;173(4):1281-1287.
  • Karlowsky JA, Kelly LJ, Thornsberry C, Jones ME, Sahm DF. Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States. Antimicrob Agents Chemother. 2002;46(8):2540-2545.
  • Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Am J Med. 2002;113(1):14-19.
  • Laxminarayan R, Duse A, Wattal C, et al. Antibiotic resistance—the need for global solutions. Lancet Infect Dis. 2013;13(12):1057-1098.
  • Akay H, Duranay M, Akay A. Üriner sistem enfeksiyonlarından izole edilen mikroorganizmaların dağılımı ve Escherichia coli suşlarında antibiyotik duyarlılığı. İstanbul Tıp Fakültesi Derg. 2006;69(1):1-4.
  • Colgan R, Williams M, Johnson JR. Diagnosis and treatment of acute pyelonephritis in women. Am Fam Physician. 2011;84(5):519-526.
  • Wayne P. National committee for clinical laboratory standards. Performance standards for antimicrobial disc susceptibility testing. 2002;12:01-53.
  • Gözüküçük R, Çakıroğlu B, Nas Y. Toplum kaynaklı üriner sistem enfeksiyonu etkeni olarak saptanan Escherichia coli izolatlarının antibiyotik duyarlılıkları. JAREM. 2012;2(3):101-103.
  • Ranjan Dash N, Albataineh MT, Alhourani N, et al. Community-acquired urinary tract infections due to extended-spectrum β -lactamase-producing organisms in United Arab Emirates. Travel Med Infect Dis. 2018;22:46-50. doi:10.1016/j.tmaid.2018.01.007
  • Dunne MW, Puttagunta S, Aronin SI, Brossette S, Murray J, Gupta V. Impact of empirical antibiotic therapy on outcomes of outpatient urinary tract infection due to nonsusceptible enterobacterales. Microbiol Spectr. 2022;10(1):e0235921.
  • Tanrıverdi-Çaycı Y, Güney DB, Ertokatlı M, Hacıeminoğlu-Ülker K, Birinci A. Prevalence of fosfomycin resistance among enterobacterales isolates in a tertiary care hospital from Turkey. Infect Dis Clin Microbiol. 2022;4(4):252-257.
  • Rock W, Colodner R, Chazan B, Elias M, Raz R. Ten years surveillance of antimicrobial susceptibility of community-acquired Escherichia coli and other uropathogens in northern Israel (1995-2005). Isr Med Assoc J. 2007;9(11):803-805.
  • Yılmaz N, Ağuş N, Bayram A, et al. Antimicrobial susceptibilities of Escherichia coli isolates as agents of community-acquired urinary tract infection (2008–2014). Turk J Urol. 2016;42(1):32.
  • Sağlam HS, Demiray V, Karabay O. Üriner enfeksiyonlarda toplum kökenli Escherichia coli'n in yeri ve gelişen antibiyotik direnci. Nobel Medicus J. 2012;8(1).
  • Schaeffer AJ. The expanding role of fluoroquinolones. Am J Med. 2002;113(1):45-54.
  • Goettsch W, Van Pelt W, Nagelkerke N, et al. Increasing resistance to fluoroquinolones in Escherichia coli from urinary tract infections in the Netherlands. J Antimicrob Chemother. 2000;46(2):223-228.
  • Taşbakan Mi, Pullukçu H, Yamazhan T, Arda B, Ulusoy S. Toplum kökenli üriner sistem infeksiyonlarindan soyutlanan Escherichia coli suşlarina fosfomisinin in-vitro etkinliğinin diğer antibiyotiklerle karşilaştirilmasi. Ankem Derg. 2004;18(4):216-219.
  • Coşkun B, Ayhan M. Toplum kökenli alt üriner sistem enfeksiyonlarının değerlendirilmesi. J Ankara University Faculty of Medicine/Ankara Üniversitesi Tip Fakültesi Mecmuasi. 2022;75(3).
  • Caskurlu H, Culpan M, Erol B, Turan T, Vahaboglu H, Caskurlu T. Changes in antimicrobial resistance of urinary tract infections in adult patients over a 5-year period. Urologia Internationalis. 2020;104(3-4):287-292.
  • Pullukçu H, Aydemir Ş, Taşbakan MI, Sipahi OR, Çilli F, Ulusoy S. Nitrofurantoinin idrar kültürlerinden soyutlanan Escherichia coli suşlarına in vitro etkinliği. İnfeksiyon Derg. 2007;21(4):197-200.
  • Baylan O. Fosfomisin: dünü, bugünü ve geleceği. Mikrobiyoloji Bülteni. 2010;44(2):311-321.
  • Kurt Ö, Güneş H, Gümüş A, Mutlu R, Topkaya AE. Toplumsal kaynaklı üriner sistem infeksiyonlarından izole edilen Escherichia coli suşlarında fosfomisin, nitrofurantoin ve siprofloksasinin in-vitro etkinliği. ANKEM Derg. 2014;28(2):58-62.
Year 2023, Volume: 6 Issue: 6, 1158 - 1161, 29.10.2023
https://doi.org/10.32322/jhsm.1350956

Abstract

References

  • Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103-e120.
  • Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med. 2002;113(1):5-13.
  • Demirtürk N, Demirdal T, Eldemir H, İnce R, Altındiş M. İdrar örneklerinden izole edilen bakterilerin antibiyotiklere duyarlılıkları. Türk Mikrobiyol Cem Derg. 2005;35(2):103-106.
  • Foxman B. Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden. Infect Dis Clin. 2014;28(1):1-13.
  • Griebling TL. Urologic diseases in America project: trends in resource use for urinary tract infections in women. J Urol. 2005;173(4):1281-1287.
  • Karlowsky JA, Kelly LJ, Thornsberry C, Jones ME, Sahm DF. Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States. Antimicrob Agents Chemother. 2002;46(8):2540-2545.
  • Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Am J Med. 2002;113(1):14-19.
  • Laxminarayan R, Duse A, Wattal C, et al. Antibiotic resistance—the need for global solutions. Lancet Infect Dis. 2013;13(12):1057-1098.
  • Akay H, Duranay M, Akay A. Üriner sistem enfeksiyonlarından izole edilen mikroorganizmaların dağılımı ve Escherichia coli suşlarında antibiyotik duyarlılığı. İstanbul Tıp Fakültesi Derg. 2006;69(1):1-4.
  • Colgan R, Williams M, Johnson JR. Diagnosis and treatment of acute pyelonephritis in women. Am Fam Physician. 2011;84(5):519-526.
  • Wayne P. National committee for clinical laboratory standards. Performance standards for antimicrobial disc susceptibility testing. 2002;12:01-53.
  • Gözüküçük R, Çakıroğlu B, Nas Y. Toplum kaynaklı üriner sistem enfeksiyonu etkeni olarak saptanan Escherichia coli izolatlarının antibiyotik duyarlılıkları. JAREM. 2012;2(3):101-103.
  • Ranjan Dash N, Albataineh MT, Alhourani N, et al. Community-acquired urinary tract infections due to extended-spectrum β -lactamase-producing organisms in United Arab Emirates. Travel Med Infect Dis. 2018;22:46-50. doi:10.1016/j.tmaid.2018.01.007
  • Dunne MW, Puttagunta S, Aronin SI, Brossette S, Murray J, Gupta V. Impact of empirical antibiotic therapy on outcomes of outpatient urinary tract infection due to nonsusceptible enterobacterales. Microbiol Spectr. 2022;10(1):e0235921.
  • Tanrıverdi-Çaycı Y, Güney DB, Ertokatlı M, Hacıeminoğlu-Ülker K, Birinci A. Prevalence of fosfomycin resistance among enterobacterales isolates in a tertiary care hospital from Turkey. Infect Dis Clin Microbiol. 2022;4(4):252-257.
  • Rock W, Colodner R, Chazan B, Elias M, Raz R. Ten years surveillance of antimicrobial susceptibility of community-acquired Escherichia coli and other uropathogens in northern Israel (1995-2005). Isr Med Assoc J. 2007;9(11):803-805.
  • Yılmaz N, Ağuş N, Bayram A, et al. Antimicrobial susceptibilities of Escherichia coli isolates as agents of community-acquired urinary tract infection (2008–2014). Turk J Urol. 2016;42(1):32.
  • Sağlam HS, Demiray V, Karabay O. Üriner enfeksiyonlarda toplum kökenli Escherichia coli'n in yeri ve gelişen antibiyotik direnci. Nobel Medicus J. 2012;8(1).
  • Schaeffer AJ. The expanding role of fluoroquinolones. Am J Med. 2002;113(1):45-54.
  • Goettsch W, Van Pelt W, Nagelkerke N, et al. Increasing resistance to fluoroquinolones in Escherichia coli from urinary tract infections in the Netherlands. J Antimicrob Chemother. 2000;46(2):223-228.
  • Taşbakan Mi, Pullukçu H, Yamazhan T, Arda B, Ulusoy S. Toplum kökenli üriner sistem infeksiyonlarindan soyutlanan Escherichia coli suşlarina fosfomisinin in-vitro etkinliğinin diğer antibiyotiklerle karşilaştirilmasi. Ankem Derg. 2004;18(4):216-219.
  • Coşkun B, Ayhan M. Toplum kökenli alt üriner sistem enfeksiyonlarının değerlendirilmesi. J Ankara University Faculty of Medicine/Ankara Üniversitesi Tip Fakültesi Mecmuasi. 2022;75(3).
  • Caskurlu H, Culpan M, Erol B, Turan T, Vahaboglu H, Caskurlu T. Changes in antimicrobial resistance of urinary tract infections in adult patients over a 5-year period. Urologia Internationalis. 2020;104(3-4):287-292.
  • Pullukçu H, Aydemir Ş, Taşbakan MI, Sipahi OR, Çilli F, Ulusoy S. Nitrofurantoinin idrar kültürlerinden soyutlanan Escherichia coli suşlarına in vitro etkinliği. İnfeksiyon Derg. 2007;21(4):197-200.
  • Baylan O. Fosfomisin: dünü, bugünü ve geleceği. Mikrobiyoloji Bülteni. 2010;44(2):311-321.
  • Kurt Ö, Güneş H, Gümüş A, Mutlu R, Topkaya AE. Toplumsal kaynaklı üriner sistem infeksiyonlarından izole edilen Escherichia coli suşlarında fosfomisin, nitrofurantoin ve siprofloksasinin in-vitro etkinliği. ANKEM Derg. 2014;28(2):58-62.

Details

Primary Language English
Subjects Infectious Diseases
Journal Section Original Article
Authors

Dilek BULUT 0000-0001-5874-174X

Hanife Nur KARAKOÇ 0000-0002-4620-6755

Early Pub Date October 28, 2023
Publication Date October 29, 2023
Published in Issue Year 2023 Volume: 6 Issue: 6

Cite

AMA BULUT D, KARAKOÇ HN. Distribution of bacteria isolated from urine cultures and resistance pattern of Escherichia coli strains in community-acquired urinary tract infections. J Health Sci Med / JHSM. October 2023;6(6):1158-1161. doi:10.32322/jhsm.1350956

Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS].

The Directories (indexes) and Platforms we are included in are at the bottom of the page.

Note: Our journal is not WOS indexed and therefore is not classified as Q.

You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. https://dergipark.org.tr/tr/journal/2316/file/4905/show







The indexes of the journal are ULAKBİM TR Dizin, Index Copernicus, ICI World of Journals, DOAJ, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, WorldCat (OCLC), MIAR, EuroPub, OpenAIRE, Türkiye Citation Index, Türk Medline Index, InfoBase Index, Scilit, etc.

       images?q=tbn:ANd9GcRB9r6zRLDl0Pz7om2DQkiTQXqDtuq64Eb1Qg&usqp=CAU

500px-WorldCat_logo.svg.png

atifdizini.png

logo_world_of_journals_no_margin.png

images?q=tbn%3AANd9GcTNpvUjQ4Ffc6uQBqMQrqYMR53c7bRqD9rohCINkko0Y1a_hPSn&usqp=CAU

doaj.png  

images?q=tbn:ANd9GcSpOQFsFv3RdX0lIQJC3SwkFIA-CceHin_ujli_JrqBy3A32A_Tx_oMoIZn96EcrpLwTQg&usqp=CAU

ici2.png

asos-index.png

drji.png





The platforms of the journal are Google Scholar, CrossRef (DOI), ResearchBib, Open Access, COPE, ICMJE, NCBI, ORCID, Creative Commons, etc.

COPE-logo-300x199.jpgimages?q=tbn:ANd9GcQR6_qdgvxMP9owgnYzJ1M6CS_XzR_d7orTjA&usqp=CAU

icmje_1_orig.png

cc.logo.large.png

ncbi.pngimages?q=tbn:ANd9GcRBcJw8ia8S9TI4Fun5vj3HPzEcEKIvF_jtnw&usqp=CAU

ORCID_logo.png

1*mvsP194Golg0Dmo2rjJ-oQ.jpeg


Our Journal using the DergiPark system indexed are;

Ulakbim TR Dizin,  Index Copernicus, ICI World of JournalsDirectory of Research Journals Indexing (DRJI), General Impact FactorASOS Index, OpenAIRE, MIAR,  EuroPub, WorldCat (OCLC)DOAJ,  Türkiye Citation Index, Türk Medline Index, InfoBase Index


Our Journal using the DergiPark system platforms are;

Google, Google Scholar, CrossRef (DOI), ResearchBib, ICJME, COPE, NCBI, ORCID, Creative Commons, Open Access, and etc.


Journal articles are evaluated as "Double-Blind Peer Review". 

Our journal has adopted the Open Access Policy and articles in JHSM are Open Access and fully comply with Open Access instructions. All articles in the system can be accessed and read without a journal user.  https//dergipark.org.tr/tr/pub/jhsm/page/9535

Journal charge policy   https://dergipark.org.tr/tr/pub/jhsm/page/10912


Editor List for 2022

Assoc. Prof. Alpaslan TANOĞLU (MD)  

Prof. Aydın ÇİFCİ (MD)

Prof. İbrahim Celalaettin HAZNEDAROĞLU (MD)

Prof. Murat KEKİLLİ (MD)

Prof. Yavuz BEYAZIT (MD) 

Prof. Ekrem ÜNAL (MD)

Prof. Ahmet EKEN (MD)

Assoc. Prof. Ercan YUVANÇ (MD)

Assoc. Prof. Bekir UÇAN (MD) 

Assoc. Prof. Mehmet Sinan DAL (MD)


Our journal has been indexed in DOAJ as of May 18, 2020.

Our journal has been indexed in TR-Dizin as of March 12, 2021.


17873

Articles published in the Journal of Health Sciences and Medicine have open access and are licensed under the Creative Commons CC BY-NC-ND 4.0 International License.