Strategies and Immun Mechanisms for Inducing Tolerance in Transplantation

Abstract

Organ and tissue transplantation is a life saving procedure for various end stage diseases. However, the recipient can develop a rejection process that attacks and destroys the donated foreign organ or tissue. To reduce this rejection risk, the recipient may need to use lifelong immunosuppressive drugs. The requirement for lifelong immunosuppressive drug usage comes with a series of side effects, such as infection, neoplasm development and organ toxicity. Therefore, minimizing or discontinuing immunosuppressive drugs is the primary goal in transplantation. This goal has been achieved in patients who have developed tolerance to grafts. Immune tolerance or immunological tolerance, is a condition in which the immune system of an organism loses its capacity to mount an immune response against a specific substance or tissue. In this review, we will examine the latest developments in the search for tolerance mechanisms.

Keywords

• Transplantation
• Immune Tolerance
• Tolerance Mechanisms

Transplantasyonda Tolerans Oluşturma Stratejileri ve İmmün Mekanizmalar

Abstract

Doku ve organ nakli, çeşitli son evre hastalıklar için hayat kurtaran bir prosedürdür. Ancak, alıcıda bağışlanan yabancı organa veya dokuya saldıran ve yok eden bir reddetme süreci yaratabilir. Bu reddetme riskini azaltmak için alıcı ömür boyu immunosupresif ilaçları kullanmak zorunda kalabilir. Ömür boyu immunosupresif ilaç gereksinimi; enfeksiyon, neoplazma gelişimi, organ toksisitesi gibi bir dizi yan etkiyle birlikte gelir. Bu nedenle immunosupresif ilaçların en aza indirilmesi veya kesilmesi transplantasyonda en önemli hedeftir. Greftlere karşı tolerans geliştirilmiş olan hastalarda bu hedefe ulaşılmıştır. Bağışıklık toleransı veya immünolojik tolerans, bir organizmada bağışıklık sisteminin, belirli bir madde veya dokuya karşı bağışıklık tepkisi oluşturma kapasitesinin kaybolduğu bir durumdur. Bu derlemede, tolerans mekanizmaları arayışındaki en son gelişmeleri gözden geçireceğiz.

Keywords

• Transplantasyon
• Bağışıklık Toleransı
• Tolerans Mekanizmaları

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