Acinetobacter baumannii Infection Risk of Mortality Among Patients in Intensive Care Units, With the Potential Impact of Age and Gender on Illnesses and Comorbidities

Abstract

Objectives: Acinetobacter baumannii is most prevalent in intensive care units (ICUs) and associated with a high mortality rate. Therefore, the objective of this study was to highlight the factors that contribute to raising mortality rates for A. baumannii in the ICU.                                                                                                                      

Methods: This study, which is retrospective descriptive in nature, was carried out at Training and Research Hospital. A. baumannii isolates from 26 patients have been included for this study. The analysis included clinical features, comorbidity factors, mortality rates, antibiotic resistance profiles, and distribution in the intensive care unit. IBM SPSS 26, produced by IBM Corporation (International Business Machines Corporation), was also used to evaluate relationships between the independent variables IVs (age/gender) and dependent variables DVs (diseases/comorbidities) of A. baumannii-infected patients.                                                                          

Results: The study indicated that 73% of the patients were over 60 years old, with 65.39% male and 34.61% female. A. baumannii cases were most commonly associated with respiratory tract infections (46.14%) and a significant prevalence of COVID-19 infection. Tracheal aspirates and sputum constituted the most common source for A. baumannii (65.38). A. baumannii was most common in the Pandemic Intensive Care Unit and Anaesthesia Intensive Care Unit, with percentages of 30.76% and 23.08%, respectively. Hypertension and diabetes mellitus were the most prevalent comorbidities. The majority of the isolates (77%) showed an intermediate response to tigecycline, whereas all A. baumannii isolates were sensitive to colistin. According to SPSS, gender (male/female) had a positive effect on ICU patients as a risk factor.                                                                                                                                             

Conclusion: Physicians can benefit from this realistic surveillance data in their decision-making processes for patients who may be particularly vulnerable to A. baumannii infections.   

Keywords

• Acinetobacter baumannii
• intensive care infection
• intensive care unit

Yoğun Bakım Ünitelerindeki Hastalarda Acinetobacter Baumannii Enfeksiyonunun Ölüm Riski Üzerine Yaş, Cinsiyetin ve Eşlik Eden Hastalıkların Potansiyel Etkisi

Abstract

Amaç: Acinetobacter baumannii, yoğun bakım ünitelerinde (YBÜ) en sık görülen ve yüksek ölüm oranıyla ilişkili bir bakteridir. Bu nedenle, bu çalışmanın amacı, YBÜ’de A. baumannii’ye bağlı ölüm oranlarını artıran faktörleri ortaya koymaktır.                                                              

Yöntem: Bu çalışma, retrospektif tanımlayıcı nitelikte olup, Eğitim ve Araştırma Hastanesi’nde gerçekleştirilmiştir. Çalışmaya 26 hastadan elde edilen A. baumannii izolatları dahil edilmiştir. Analiz, klinik özellikler, eşlik eden hastalık faktörleri, ölüm oranları, antibiyotik direnç profilleri ve yoğun bakım ünitesindeki dağılımı içermiştir. IBM tarafından üretilen IBM SPSS 26 programı, A. baumannii enfeksiyonu olan hastaların bağımsız değişkenleri (yaş/cinsiyet) ve bağımlı değişkenleri (hastalıklar/eşlik eden hastalıklar) arasındaki ilişkileri değerlendirmek için de kullanılmıştır.                                                                                

Bulgular: Çalışma, hastaların %73’ünün 60 yaş üstü olduğunu, %65,39’unun erkek ve %34,61’inin kadın olduğunu göstermiştir. A. baumannii vakaları en sık solunum yolu enfeksiyonlarıyla (%46,14) ve önemli bir COVID-19 enfeksiyonu prevalansıyla ilişkilendirilmiştir. Trakeal aspiratlar ve balgam, A. baumannii için en yaygın kaynak olmuştur (%65,38). A. baumannii, sırasıyla %30,76 ve %23,08 oranlarıyla Pandemi Yoğun Bakım Ünitesi ve Anestezi Yoğun Bakım Ünitesinde en sık görülmüştür. Hipertansiyon ve diyabet mellitus en yaygın eşlik eden hastalıklar olmuştur. İzolatların çoğunluğu (%77) tigesiklin ‘e orta düzeyde yanıt verirken, tüm A. baumannii izolatları kolistine duyarlıydı. SPSS’e göre, cinsiyet (erkek/kadın) risk faktörü olarak yoğun bakım hastaları üzerinde olumlu bir etkiye vardı.                                                                                       

Sonuç: Hekimler, A. baumannii enfeksiyonlarına karşı özellikle savunmasız olabilecek hastalar için karar verme süreçlerinde bu gerçekçi sürveyans verilerinden faydalanabilirler.     

Keywords

• Acinetobacter baumannii
• yogun bakim enfeksiyonu
• yogun bakim unitesi

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