Use of C-reactive protein in the evaluation of Widal test and Typhoid stripe test in the diagnosis of typhoid fever

Year 2017, , 16 - 20, 30.03.2017

Ahmed Hasan Mohammed

https://doi.org/10.5455/jicm.17.20160921

Abstract

Background: Typhoid
fever is one of the systemic infection and responsible for high rate of
mortality especially in poor hygiene provinces. The aim of this study was to
evaluate the methods including C-reactive protein test, Widal test and        Typhoid stripe test that used in the
diagnosis of typhoid fever.

Material and Methods: Rapid direct Widal agglutination test and rapid typhoid
stripe (immunochromatography) test were used to detect typhoid infection
evaluate more accurate method in the diagnosis of typhoid fever. C-reactive
protein detected by rapid slide agglutination test to measure its level in
typhoid fever patients.

Results: The
results of Widal test showed 29 (63%) of 46 sample while the results of typhoid
stripe test showed 25 (54.3%) IgM positive and 2 (4.3%) IgG positive from 46
sample. The test of CRP accomplished in positive widal test and positive
typhoid strip test samples, the results showed that 6 (20.6%) of 29 were
positive and 6 (24%) of 25 were positive in widal and typhoid positive samples
respectively.

Conclusion: Typhoid
stripe test is more accurate and has low cross reactivity when compared with
Widal test in the diagnosis of typhoid fever. Although, C-reactive protein test
is non-specific but it is helpful in the characterization of acute inflammation
and infection, so it is recommended to use in the detection of typhoid fever.

Keywords

Typhoid fever, Widal test, typhoid stripe test, CRP

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