Barsak Mikrobiyotasının Nörodejeneratif Hastalıklar Üzerindeki Patofizyolojik Rolü

Abstract

Barsak mikrobiyotasını oluşturan virüs, bakteri, mantar ve protozoa gibi birçok mikroorganizma türü; fizyolojik adaptasyon, diyet, ilaç tüketimi gibi birçok etmen nedeniyle oldukça çeşitlilik göstermektedir. Mikrobiyotanın bu etmenlerden olumsuz etkilenmesi durumuna disbiyosiz adı verilir. Barsak ile beyin arasında, enterik sinir ağı, vagus siniri, immün sistem ve mikroorganzimaların oluşturduğu biyokimyasal reaksiyonların sonuçları olmak üzere birçok ilişki bulunmaktadır. Beyin ile barsak arasındaki bu bağlantı, disbiyosiz durumunda Alzheimer, Parkinson gibi nörolojik hastalıkların tetikleyicisi olabilir. Son yıllarda prebiyotik, probiyotik ve fekal transplantasyon gibi yeni tedavi yöntemlerinin kullanılması, bağısak-beyin arasındaki nöropatolojik ilişki üzerinde oldukça önemlidir.

Keywords

• Alzheimer,Nöroinflamasyon,Mikrobiyota,Parkinson

Pathophysiologic Role of Intestinal Microbiota on Neurodegenerative Diseases

Abstract

Many types of microorganisms such as viruses, bacteria, fungi and protozoa that form the intestinal microbiota; physiological adaptation, diet, drug consumption vary greatly due to many factors such as. If the microbiota is affected negatively by these factors, it is called as dysbiosis. There are many relationships between the intestine and the brain, the results of the biochemical reactions of the enteric neural network, vagus nerve, immune system and microorganisms. This linkage between the brain and the intestine may be the trigger of neurological diseases such as Alzheimer's and Parkinson's in the case of dysbiosis. In recent years, the use of new treatment modalities such as prebiotic, probiotic and fecal transplantation is very important in the neuropathological relationship between the brain and the intestine.

Keywords

• Alzheimer,Neuroinflammation,Microbiota,Parkinson

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