Changes in Antibiotic Susceptibility of Urinary Tract Pathogens in Pediatric Population by Years

Abstract

Abstract Background: Urinary tract infection is one of the most common infections in the community and is more common in children than adults. In this study, it was aimed to investigate the distribution of the isolated microorganisms from pediatric patients, their susceptibility status, and the change in resistance by years in order to help clinicians manage the empirical medical treatment. Materials and Methods: 3337 children with a preliminary diagnosis of urinary tract infection who applied to Gebze Fatih State Hospital between January 2013 and December 2018 were included in the study. Urine culture results and antibiotic susceptibilities were analyzed retrospectively and examined over years. Results: The susceptibility rates of E. coli species to ampicillin, trimethoprim-sulfamethoxazole, cefuroxime, and cefixime were 35.5%, 66.6%, 64.5%, and 68.8%, respectively. There was a significant decrease in antibiotic susceptibility of E. coli isolates for cefoxitin (p=0.04), ceftazidime (p<0.001), amikacin (p<0.001) and nitrofurantoin (p<0.001) by years. Susceptibility rates against amikacin (p=0.04) and nitrofurantoin (p<0.001) in Klebsiella isolates decreased significantly by years. There was a significant decrease in Pseudomonas isolates thereby years in the rate of susceptibility to ceftazidime (p=0.019). There was no significant change in susceptibility rates for any antibiotic in Proteus isolates by years (p>0.05 for each). Conclusions: Cefixime was found that the most effective oral antibiotic against E. Coli. The most effective antibiotics were fosfomycin and carbapenems in the Enterobacteriaceae group. The antibiotic resistance of causative pathogens has been shown to increase over the years. Therefore, the antibiotic susceptibilities of bacteria should be monitored periodically.

Keywords

• Urinary infection
• Pediatric patients
• Antibiotics susceptibility

References

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