Role of anticardiolipin antibodies in bad obstetric history detected by ELISA test in a tertiary care centre

Year 2017, Volume: 2 Issue: 2, 43 - 47, 30.06.2017

Therese Mary Dhason

https://doi.org/10.5455/jicm.24.259659

Abstract

Background: Antiphospholipid
syndrome (APS) is one of the causes of recurrent abortions and intrauterine
death among pregnant women. This study was undertaken to find out the
association between bad obstetric history (BOH) and anticardiolipin (aCL)
antibody.

Material and Methods: Blood samples were collected from women with BOH referred
(recurrent abortion, intrauterine death, PIH) to a Tertiary Care Center in
Chennai, Tamil Nadu. Blood samples from 100 pregnant women with BOH and 110
healthy pregnant women were collected and tested for the presence of  aCL antibody by ELISA Method.

Results: Among
the 100 patients tested 21 (21%) were aCL 
positive; IgG was positive in 16 (76.19%) patients and IgM was positive
in 5(23.80%) patients. Anticordiolipin antibody (aCL) positivity in BOH was
statistically significant (p .0048) when compared to healthy pregnant women.
There was a positive correlation (p 0.005) between IgG and BOH. The antibody
titer was high in 12 (57.14%) and moderate in 6 (28.57%). Among the controls 8(7.2%)
were aCL  positive.

Conclusion: Screening
of patients with BOH for aCL by ELISA will reduce foetal morbidity and
mortality as there is a significant association between high, moderate titers
of aCL, (IgG) and BOH.

Keywords

Antiphospholipid syndrome, Anticordiolipin Elisa, Bad Obstetric History

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