Year 2018, Volume , Issue , Pages 53 - 57 2018-06-05

The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey

Aysin Zeytinoglu, et al. [1]


Background: The emergence of cytomegalovirus (CMV) resistance to antivirals causes an increasing problem in transplant recipients, complicating therapeutic and clinical management. Widely used antivirals for therapy, preemptive therapy, and prophylaxis are the causes for resistance. This study aimed to report the first two transplant recipients who had CMV ganciclovir (GCV) resistance assessed by UL97 viral gene sequencing in Turkey.

Case presentation: CMV infection was monitored by plasma quantitative viral DNA real-time polymerase chain reaction (Abbott Molecular Inc., Illınois, USA) in the transplant recipients. Sequence analysis of CMV UL97 in CMV DNA–positive cases for GCV resistance was conducted, and while looking for UL97 GCV resistance in Ege University hospital, the first renal transplantation recipient with CMV mutation in Turkey was detected. Also, a  stem cell transplant recipient was the first case for pediatric stem cell transplantation having UL97 GCV-resistant strain in Turkey. A594V and C603W mutations were the detected mutations, respectively.

Conclusion: Using GCV/valganciclovir (VGCV) for preemptive therapy, prophylaxis, treatment, and especially maintenance therapy for a long time with VGCV when CMV DNA is still detectable in peripheral blood might represent a risk factor for the emergence of CMV GCV resistance. The present findings indicate that resistance to widely used GCV as therapy, preemptive therapy, and prophylaxis should be monitored carefully in transplant recipients routinely for good patient management and effective antiviral therapy.

Cytomegalovirus, ganciclovir resistance, mutation, UL97
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Primary Language en
Subjects Medicine
Journal Section Research Articles
Authors

Author: Aysin Zeytinoglu, et al.

Dates

Publication Date : June 5, 2018

Bibtex @research article { jicm422125, journal = {Journal of Immunology and Clinical Microbiology}, issn = {}, eissn = {2528-9470}, address = {Adalet mh. 1643/18 Sk. bina no:6 smyrnapark evleri b blok daire 16, Bayraklı, İzmir}, publisher = {Erkan YULA}, year = {2018}, volume = {}, pages = {53 - 57}, doi = {10.5455/jicm.12.2016070}, title = {The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey}, key = {cite}, author = {Zeytinoglu, et al., Aysin} }
APA Zeytinoglu, et al., A . (2018). The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey. Journal of Immunology and Clinical Microbiology , () , 53-57 . DOI: 10.5455/jicm.12.2016070
MLA Zeytinoglu, et al., A . "The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey". Journal of Immunology and Clinical Microbiology (2018 ): 53-57 <https://dergipark.org.tr/en/pub/jicm/issue/36924/422125>
Chicago Zeytinoglu, et al., A . "The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey". Journal of Immunology and Clinical Microbiology (2018 ): 53-57
RIS TY - JOUR T1 - The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey AU - Aysin Zeytinoglu, et al. Y1 - 2018 PY - 2018 N1 - doi: 10.5455/jicm.12.2016070 DO - 10.5455/jicm.12.2016070 T2 - Journal of Immunology and Clinical Microbiology JF - Journal JO - JOR SP - 53 EP - 57 VL - IS - SN - -2528-9470 M3 - doi: 10.5455/jicm.12.2016070 UR - https://doi.org/10.5455/jicm.12.2016070 Y2 - 2019 ER -
EndNote %0 Journal of Immunology and Clinical Microbiology The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey %A Aysin Zeytinoglu, et al. %T The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey %D 2018 %J Journal of Immunology and Clinical Microbiology %P -2528-9470 %V %N %R doi: 10.5455/jicm.12.2016070 %U 10.5455/jicm.12.2016070
ISNAD Zeytinoglu, et al., Aysin . "The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey". Journal of Immunology and Clinical Microbiology / (June 2018): 53-57 . https://doi.org/10.5455/jicm.12.2016070
AMA Zeytinoglu, et al. A . The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey. J Immunol Clin Microbiol. 2018; 53-57.
Vancouver Zeytinoglu, et al. A . The first two ganciclovir resistant cytomegalovirus isolates from kidney and pediatric stem cell transplant recipients in Turkey. Journal of Immunology and Clinical Microbiology. 2018; 57-53.