Microbiota: A Potential Therapy for Autism .

Year 2020, Volume: 5 Issue: 3, 97 - 105, 30.09.2020

Berna Özdem

Abstract

Gastrointestinal symptoms are a common problem in patients with autism spectrum disorder (ASD), but the underlying mechanisms are unknown. Autistic children often suffer gastrointestinal (GI) problems that correlate with ASD severity. Several previous studies have reported abnormal gut bacteria in children with Autism disease. The gut microbiota-Autism connection has been tested in a mouse model of Autism, where the microbiome was mechanistically linked to abnormal metabolites and behavior. Similarly, a study of children with Autism spectrum disorder found that oral non-absorbable antibiotic treatment improved GI and ASD symptoms, albeit temporarily.
In this review, Autism and their therapy with gut microbiota are summarized. These studies are among the most promising areas of research for human health; however, further studies are needed before clinical practice.

Keywords

Autism, Microbiota, Gut, Intestine, probiotics, fecal microbiota transplantation (FMT)

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