Research Article
BibTex RIS Cite

Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study

Year 2024, Volume: 9 Issue: 4, 101 - 108
https://doi.org/10.58854/jicm.1556194

Abstract

Objective: The purpose of the research is to evaluate antibiotic consumption in hospitalized patients with a single-day point prevalence study.
Material and Methods: The study was conducted at Yalova Training and Research Hospital (YTRH) on April 12, 2023. The research day, patients in all clinics and intensive care units were visited, and information about the sociodemographic data of the patients and the antibiotics used was recorded in the antibiotic consumption form. The resulting box-based consumption was analyzed in the SPSS program in the Defined Daily Dose (DDD) unit of the World Health Organization.
Results: 150 patients included in the research, and 100 patients received antibiotics. Antibiotic use rate was found to be 66.66%. 55 of the patients receiving antibiotics were female and the mean age was 66.36±18.54 (min:19, max:92) years. The total amount of antibiotics consumed was 839.60 DDD/1000 patient-days (DPD). When antibiotic consumption was evaluated according to units, it was seen that the patients using antibiotics the most were in surgical wards (n: 47; 227.4 DPD), and the highest antibiotic consumption was in intensive care units (ICU) (n: 29; 399.83 DPD). The first three antibiotics most used in the hospital were moxifloxacin, ceftricasone and ciprofloxacin, respectively.
Conclusions: The study found that 66% of patients used at least one antibiotic, the most commonly used units were the ICU, and the most commonly used antibiotic groups were quinolones, cephalosporins and carbapenems. Antibiotic consumption should be monitored using the point prevalence method, feedback should be provided and awareness should be raised by implementing antibiotic stewardship programs in the hospital.

Ethical Statement

Çalışmanın etik onayı Yalova Üniversitesi İnsan Araştırmaları Etik Kurulu'ndan 2023/109 protokol numarasıyla alındı.

Supporting Institution

Yoktur.

Project Number

Yoktur.

Thanks

Yoktur.

References

  • Tokur Kesgin M, Zengin S, Çağlar S. Antibiotic Use in Society: A Section from Bolu Province. Ahi Evran Medical Journal. 2023; 7(2), 145-154.
  • Huemer M, Mairpady Shambat S, Brugger SD, Zinkernagel AS. Antibiotic resistance and persistence—Implications for human health and treatment perspectives. EMBO reports. 2020; 21(12), e51034.
  • Hutchings MI, Truman AW, Wilkinson B. Antibiotics: past, present and futur. Curr Opin Microbiol. 2019;(51):72-80.
  • Nepal A, Hendrie D, Selvey LA, Robinson S. Factors influencing the inappropriate use of antibiotics in the Rupandehi district of Nepal. Int J Health Plann Manage, 2021; 36(1):42-59.
  • Erdeniz EH, Dursun A. Evaluation of inappropriate antibiotic use in pediatric patients: Point-prevalence study. Journal of Pediatric Infection, 2020; 14(2)
  • Giorgia S, Sena S, Sumanth G. How can we tackle the overuse of antibiotics in low- and middle-income countries?. Expert Review of Anti-infective Therapy. 2023; 21:11, pages 1189-1201.
  • Gaygısız Ü, Lajunen T, Gaygısız E. Community Use of Antibiotics in Turkey: The Role of Knowledge, Beliefs, Attitudes, and Health Anxiety. Antibiotics (Basel). 2021; 27;10(10):1171.
  • World Health Organization (WHO). Turkey takes strong action to reduce antibiotic consumption and resistance. Accessed on December 22, 2023. Available from: https://www.euro.who.int/en/health-opics/disease-prevention/antimicrobial- resistance/news/news/2017/11/turkey-takes-strong-action-to-reduce-antibiotic-consumption-and-resistance
  • European Centre for Disease Prevention and Control (2016). Point Prevalence Survey of Healthcare Associated Infections and Antimicrobial Use in European Acute Care Hospitals – Protocol Version 5.3. Stockholm: European Centre for Disease Prevention and Control. Accessed on January 15, 2024 Available from: https://www.ecdc.europa.eu/sites/default/files/media/en/publications/Publications/PPS-HAI-antimicrobial-use-EU-acute-care-hospitals-V5-3.pdf
  • Centers for Disease Control and Prevention (2021). Healthcare-Associated Infections - Community Interface (HAIC). HAI and Antibiotic Use Prevalence Survey. Centers for Disease Control and Prevention. Accessed January 15, 2024 Available from: https://www.cdc.gov/hai/eip/antibiotic-use.html
  • Global (2022). Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS)Why a Global-PPS? University of Antwerp bioMérieux. Accessed January 15, 2024 Available from: https://www.global-pps.com/project/
  • Abubakar U. Antibiotic use among hospitalized patients in northern Nigeria: a multicenter point-prevalence survey. BMC Infect Dis. 2020;30;20(1):86.
  • Saleem Z, Hassali MA, Versporten A, Godman B, Hashmi FK, Goossens H, et al. A multicenter point prevalence survey of antibiotic use in Punjab, Pakistan: findings and implications. Expert Rev Anti Infect Ther. 2019;17(4):285-293.
  • Ahoyo TA, Bankolé HS, Adéoti FM, Gbohoun AA, Assavèdo S, Amoussou-Guénou M, et al. Prevalence of nosocomial infections and anti-infective therapy in Benin: results of the first nationwide survey in 2012. Antimicrob Resist Infect Control. 2014;14;3:17.
  • Fentie AM, Degefaw Y, Asfaw G, Shewarega W, Woldearegay M, Abebe E, et al. Multicentre point-prevalence survey of antibiotic use and healthcare-associated infections in Ethiopian hospitals. BMJ Open. 2022;11;12(2):e054541.
  • Porto APM, Goossens H, Versporten A, Costa SF; Brazilian Global-PPS Working Group. Global point prevalence survey of antimicrobial consumption in Brazilian hospitals. J Hosp Infect. 2020;104(2):165-171.
  • Nunes PHC, Moreira JPL, Thompson AF, Machado TLDS, Cerbino-Neto J, Bozza FA. Antibiotic Consumption and Deviation of Prescribed Daily Dose From the Defined Daily Dose in Critical Care Patients: A Point-Prevalence Study. Front Pharmacol. 2022;16;13:913568.
  • Al Matar M, Enani M, Binsaleh G, Roushdy H, Alokaili D, Al Bannai A, et al. Point prevalence survey of antibiotic use in 26 Saudi hospitals in 2016. J Infect Public Health. 2019;12(1):77-82.
  • Frenette C, Sperlea D, German GJ, Afra K, Boswell J, Chang S, et al. The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals. Antimicrob Resist Infect Control. 2020;11;9(1):104.
  • Sözen H, Gönen I, Sözen A, Kutlucan A, Kalemci S, Sahan M. Application of ATC/DDD methodology to evaluate of antibiotic use in a general hospital in Turkey. Ann Clin Microbiol Antimicrob. 2013;3;12:23.
  • Guclu E, Ogutlu A, Karabay O, Demirdal T, Erayman I, Hosoglu S, et al. Antibiotic consumption in Turkish hospitals; a multi-centre point prevalence study. J Chemother. 2017;29(1):19-24.
  • Karabay O, Ince N, Aypak A, Guclu E, Bodur H; Group EKMUD Antibiotic Study. Antibiotic usage in hospitalized patients: a one-day point prevalence study. J Chemother. 2020;32(4):188-192.
  • Rameshkumar MR, Arunagirinathan N. Drug-resistant bacterial infections in HIV patients. Advances in HIV and AIDS Control, 2018;83.
  • World Health Organization [Internet]. WHO Collaborating Centre for Drug Statistics Methodology, Guidelines for ATC classification and DDD assignment, 2023. Oslo, 2022. Accesed January 16 2024 Available from: https://www.whocc.no/filearchive/publications/2023_guidelines_web.pdf
  • Bitterman R, Hussein K, Leibovici L, Carmeli Y, Paul M. Systematic review of antibiotic consumption in acute care hospitals. Clin Microbiol Infect. 2016;22(6):561.e7-561.e19.
  • Vu TVD, Do TTN, Rydell U, Nilsson LE, Olson L, Larsson M, et al. Antimicrobial susceptibility testing and antibiotic consumption results from 16 hospitals in Viet Nam: The VINARES project 2012-2013. J Glob Antimicrob Resist. 2019;18:269-278.
  • Kim B, Hwang H, Kim J, Lee MJ, Pai H. Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013. Korean J Intern Med. 2020;35(3):703-713.
  • Antimicrobial Use and Resistance in Australia (AURA) 2021. Fourth Australian report on antimicrobial use and resistance in human health. Accesed 21 January 2024 Available from: https://www.safetyandquality.gov.au/sites/default/files/2021-09/aura_2021_-_report_-_final_accessible_pdf_-_for_web_publication.pdf
  • Dumartin C, L’Hériteau F, Péfau M, Bertrand X, Jarno P, Boussat S, et al. Antibiotic use in 530 French hospitals: results from a surveillance network at hospital and ward levels in 2007. J Antimicrob Chemother. 2010;65(9):2028-36.
  • Sekoni KF, Oreagba IA, Oladoja FA. Antibiotic utilization study in a teaching hospital in Nigeria. JAC Antimicrob Resist. 2022;5;4(5):dlac093.
  • Romo-Castillo HF, Pazin-Filho A. Towards implementing an antibiotic stewardship programme (ASP) in Ecuador: evaluating antibiotic consumption and the impact of an ASP in a tertiary hospital according to World Health Organization (WHO) recommendations. J Glob Antimicrob Resist. 2022;29:462-467.
  • Borg MA, Zarb P, Ferech M, Goossens H; ARMed Project Group. Antibiotic consumption in southern and eastern Mediterranean hospitals: results from the ARMed project. J Antimicrob Chemother. 2008;62(4):830-6.
  • Trejnowska E, Deptuła A, Tarczyńska-Słomian M, Knapik P, Jankowski M, Misiewska-Kaczur A, et al. Surveillance of Antibiotic Prescribing in Intensive Care Units in Poland. Can J Infect Dis Med Microbiol. 2018;28;2018:5670238.
  • Murila BL, Nyamu DG, Kinuthia RN, Njogu PM. Rational use of antibiotics and covariates of clinical outcomes in patients admitted to intensive care units of a tertiary hospital in Kenya. Hosp Pract (1995). 2022;50(2):151-158.
  • Anand Paramadhas BD, Tiroyakgosi C, Mpinda-Joseph P, Morokotso M, Matome M, Sinkala F, et al. Point prevalence study of antimicrobial use among hospitals across Botswana; findings and implications. Expert Rev Anti Infect Ther. 2019;17(7):535-546.

Hastanede Antibiyotik Tüketiminin İncelenmesi: Tek Merkezli Nokta Prevalans Çalışması

Year 2024, Volume: 9 Issue: 4, 101 - 108
https://doi.org/10.58854/jicm.1556194

Abstract

Amaç: Bu çalışmanın amacı, hastanede yatan hastalarda antibiyotik tüketimini tek günlük nokta prevalans çalışmasıyla değerlendirmektir.
Gereç ve Yöntem: Çalışma, 12 Nisan 2023 tarihinde Yalova Eğitim ve Araştırma Hastanesi›nde (YEAH) gerçekleştirildi. Araştırma günü, tüm servis ve YBÜ’deki hastalar ziyaret edilerek hastaların sosyodemografik verileri ve kullanılan antibiyotiklere ilişkin bilgiler antibiyotik tüketim formuna kaydedildi. Elde edilen kutu bazlı tüketim, Dünya Sağlık Örgütü›nün Günlük Tanımlanmış Doz (GTD) biriminde SPSS programında analiz edildi.
Bulgular: Araştırmaya 150 hasta dahil edildi ve 100 hastanın antibiyotik aldığı tespit edildi. Antibiyotik kullanım oranı %66,66 olarak belirlendi. Antibiyotik kullanan hastaların %55’i kadın olup yaş ortalaması 66,36±18,54 (min:19, max:92) yıl idi. Tüketilen toplam antibiyotik miktarı 839,60 GDD/1000 hasta-günü (GHG) idi. Birimlere göre antibiyotik tüketimi değerlendirildiğinde en fazla antibiyotik kullanan hastaların cerrahi servislerde (n:47; 227,4 GHG) olduğu, en fazla antibiyotik tüketiminin ise yoğun bakım üniteleri (YBÜ)’nde (n:29; 399,83 GHG) olduğu görüldü. Hastanede en çok kullanılan ilk üç antibiyotik sırasıyla moksifloksasin, seftriakson ve siprofloksasin oldu.
Sonuç: Araştırmada hastaların %66’sının en az bir antibiyotik kullandığı, en çok kullanılan birimlerin YBÜ olduğu, en çok kullanılan antibiyotik gruplarının ise kinolonlar, sefalosporinler ve karbapenemler olduğu belirlendi. Nokta prevalans yöntemiyle antibiyotik tüketimi izlenmeli, geri bildirim sağlanmalı ve hastanede antibiyotik yönetim programları uygulanarak farkındalık artırılmalıdır.

Project Number

Yoktur.

References

  • Tokur Kesgin M, Zengin S, Çağlar S. Antibiotic Use in Society: A Section from Bolu Province. Ahi Evran Medical Journal. 2023; 7(2), 145-154.
  • Huemer M, Mairpady Shambat S, Brugger SD, Zinkernagel AS. Antibiotic resistance and persistence—Implications for human health and treatment perspectives. EMBO reports. 2020; 21(12), e51034.
  • Hutchings MI, Truman AW, Wilkinson B. Antibiotics: past, present and futur. Curr Opin Microbiol. 2019;(51):72-80.
  • Nepal A, Hendrie D, Selvey LA, Robinson S. Factors influencing the inappropriate use of antibiotics in the Rupandehi district of Nepal. Int J Health Plann Manage, 2021; 36(1):42-59.
  • Erdeniz EH, Dursun A. Evaluation of inappropriate antibiotic use in pediatric patients: Point-prevalence study. Journal of Pediatric Infection, 2020; 14(2)
  • Giorgia S, Sena S, Sumanth G. How can we tackle the overuse of antibiotics in low- and middle-income countries?. Expert Review of Anti-infective Therapy. 2023; 21:11, pages 1189-1201.
  • Gaygısız Ü, Lajunen T, Gaygısız E. Community Use of Antibiotics in Turkey: The Role of Knowledge, Beliefs, Attitudes, and Health Anxiety. Antibiotics (Basel). 2021; 27;10(10):1171.
  • World Health Organization (WHO). Turkey takes strong action to reduce antibiotic consumption and resistance. Accessed on December 22, 2023. Available from: https://www.euro.who.int/en/health-opics/disease-prevention/antimicrobial- resistance/news/news/2017/11/turkey-takes-strong-action-to-reduce-antibiotic-consumption-and-resistance
  • European Centre for Disease Prevention and Control (2016). Point Prevalence Survey of Healthcare Associated Infections and Antimicrobial Use in European Acute Care Hospitals – Protocol Version 5.3. Stockholm: European Centre for Disease Prevention and Control. Accessed on January 15, 2024 Available from: https://www.ecdc.europa.eu/sites/default/files/media/en/publications/Publications/PPS-HAI-antimicrobial-use-EU-acute-care-hospitals-V5-3.pdf
  • Centers for Disease Control and Prevention (2021). Healthcare-Associated Infections - Community Interface (HAIC). HAI and Antibiotic Use Prevalence Survey. Centers for Disease Control and Prevention. Accessed January 15, 2024 Available from: https://www.cdc.gov/hai/eip/antibiotic-use.html
  • Global (2022). Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS)Why a Global-PPS? University of Antwerp bioMérieux. Accessed January 15, 2024 Available from: https://www.global-pps.com/project/
  • Abubakar U. Antibiotic use among hospitalized patients in northern Nigeria: a multicenter point-prevalence survey. BMC Infect Dis. 2020;30;20(1):86.
  • Saleem Z, Hassali MA, Versporten A, Godman B, Hashmi FK, Goossens H, et al. A multicenter point prevalence survey of antibiotic use in Punjab, Pakistan: findings and implications. Expert Rev Anti Infect Ther. 2019;17(4):285-293.
  • Ahoyo TA, Bankolé HS, Adéoti FM, Gbohoun AA, Assavèdo S, Amoussou-Guénou M, et al. Prevalence of nosocomial infections and anti-infective therapy in Benin: results of the first nationwide survey in 2012. Antimicrob Resist Infect Control. 2014;14;3:17.
  • Fentie AM, Degefaw Y, Asfaw G, Shewarega W, Woldearegay M, Abebe E, et al. Multicentre point-prevalence survey of antibiotic use and healthcare-associated infections in Ethiopian hospitals. BMJ Open. 2022;11;12(2):e054541.
  • Porto APM, Goossens H, Versporten A, Costa SF; Brazilian Global-PPS Working Group. Global point prevalence survey of antimicrobial consumption in Brazilian hospitals. J Hosp Infect. 2020;104(2):165-171.
  • Nunes PHC, Moreira JPL, Thompson AF, Machado TLDS, Cerbino-Neto J, Bozza FA. Antibiotic Consumption and Deviation of Prescribed Daily Dose From the Defined Daily Dose in Critical Care Patients: A Point-Prevalence Study. Front Pharmacol. 2022;16;13:913568.
  • Al Matar M, Enani M, Binsaleh G, Roushdy H, Alokaili D, Al Bannai A, et al. Point prevalence survey of antibiotic use in 26 Saudi hospitals in 2016. J Infect Public Health. 2019;12(1):77-82.
  • Frenette C, Sperlea D, German GJ, Afra K, Boswell J, Chang S, et al. The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals. Antimicrob Resist Infect Control. 2020;11;9(1):104.
  • Sözen H, Gönen I, Sözen A, Kutlucan A, Kalemci S, Sahan M. Application of ATC/DDD methodology to evaluate of antibiotic use in a general hospital in Turkey. Ann Clin Microbiol Antimicrob. 2013;3;12:23.
  • Guclu E, Ogutlu A, Karabay O, Demirdal T, Erayman I, Hosoglu S, et al. Antibiotic consumption in Turkish hospitals; a multi-centre point prevalence study. J Chemother. 2017;29(1):19-24.
  • Karabay O, Ince N, Aypak A, Guclu E, Bodur H; Group EKMUD Antibiotic Study. Antibiotic usage in hospitalized patients: a one-day point prevalence study. J Chemother. 2020;32(4):188-192.
  • Rameshkumar MR, Arunagirinathan N. Drug-resistant bacterial infections in HIV patients. Advances in HIV and AIDS Control, 2018;83.
  • World Health Organization [Internet]. WHO Collaborating Centre for Drug Statistics Methodology, Guidelines for ATC classification and DDD assignment, 2023. Oslo, 2022. Accesed January 16 2024 Available from: https://www.whocc.no/filearchive/publications/2023_guidelines_web.pdf
  • Bitterman R, Hussein K, Leibovici L, Carmeli Y, Paul M. Systematic review of antibiotic consumption in acute care hospitals. Clin Microbiol Infect. 2016;22(6):561.e7-561.e19.
  • Vu TVD, Do TTN, Rydell U, Nilsson LE, Olson L, Larsson M, et al. Antimicrobial susceptibility testing and antibiotic consumption results from 16 hospitals in Viet Nam: The VINARES project 2012-2013. J Glob Antimicrob Resist. 2019;18:269-278.
  • Kim B, Hwang H, Kim J, Lee MJ, Pai H. Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013. Korean J Intern Med. 2020;35(3):703-713.
  • Antimicrobial Use and Resistance in Australia (AURA) 2021. Fourth Australian report on antimicrobial use and resistance in human health. Accesed 21 January 2024 Available from: https://www.safetyandquality.gov.au/sites/default/files/2021-09/aura_2021_-_report_-_final_accessible_pdf_-_for_web_publication.pdf
  • Dumartin C, L’Hériteau F, Péfau M, Bertrand X, Jarno P, Boussat S, et al. Antibiotic use in 530 French hospitals: results from a surveillance network at hospital and ward levels in 2007. J Antimicrob Chemother. 2010;65(9):2028-36.
  • Sekoni KF, Oreagba IA, Oladoja FA. Antibiotic utilization study in a teaching hospital in Nigeria. JAC Antimicrob Resist. 2022;5;4(5):dlac093.
  • Romo-Castillo HF, Pazin-Filho A. Towards implementing an antibiotic stewardship programme (ASP) in Ecuador: evaluating antibiotic consumption and the impact of an ASP in a tertiary hospital according to World Health Organization (WHO) recommendations. J Glob Antimicrob Resist. 2022;29:462-467.
  • Borg MA, Zarb P, Ferech M, Goossens H; ARMed Project Group. Antibiotic consumption in southern and eastern Mediterranean hospitals: results from the ARMed project. J Antimicrob Chemother. 2008;62(4):830-6.
  • Trejnowska E, Deptuła A, Tarczyńska-Słomian M, Knapik P, Jankowski M, Misiewska-Kaczur A, et al. Surveillance of Antibiotic Prescribing in Intensive Care Units in Poland. Can J Infect Dis Med Microbiol. 2018;28;2018:5670238.
  • Murila BL, Nyamu DG, Kinuthia RN, Njogu PM. Rational use of antibiotics and covariates of clinical outcomes in patients admitted to intensive care units of a tertiary hospital in Kenya. Hosp Pract (1995). 2022;50(2):151-158.
  • Anand Paramadhas BD, Tiroyakgosi C, Mpinda-Joseph P, Morokotso M, Matome M, Sinkala F, et al. Point prevalence study of antimicrobial use among hospitals across Botswana; findings and implications. Expert Rev Anti Infect Ther. 2019;17(7):535-546.
There are 35 citations in total.

Details

Primary Language English
Subjects Medical Microbiology (Other)
Journal Section Research Articles
Authors

Gülsüm Kaya

Zeynep Ergenç 0000-0001-7598-4508

Hülya İncirkuş Küçük 0000-0002-6739-6463

Hasan Ergenç 0000-0003-0519-0264

Sebahat Aksaray 0000-0002-0552-1337

Project Number Yoktur.
Early Pub Date January 1, 2025
Publication Date
Submission Date September 25, 2024
Acceptance Date December 24, 2024
Published in Issue Year 2024 Volume: 9 Issue: 4

Cite

APA Kaya, G., Ergenç, Z., İncirkuş Küçük, H., Ergenç, H., et al. (2025). Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study. Journal of Immunology and Clinical Microbiology, 9(4), 101-108. https://doi.org/10.58854/jicm.1556194
AMA Kaya G, Ergenç Z, İncirkuş Küçük H, Ergenç H, Aksaray S. Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study. J Immunol Clin Microbiol. January 2025;9(4):101-108. doi:10.58854/jicm.1556194
Chicago Kaya, Gülsüm, Zeynep Ergenç, Hülya İncirkuş Küçük, Hasan Ergenç, and Sebahat Aksaray. “Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study”. Journal of Immunology and Clinical Microbiology 9, no. 4 (January 2025): 101-8. https://doi.org/10.58854/jicm.1556194.
EndNote Kaya G, Ergenç Z, İncirkuş Küçük H, Ergenç H, Aksaray S (January 1, 2025) Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study. Journal of Immunology and Clinical Microbiology 9 4 101–108.
IEEE G. Kaya, Z. Ergenç, H. İncirkuş Küçük, H. Ergenç, and S. Aksaray, “Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study”, J Immunol Clin Microbiol, vol. 9, no. 4, pp. 101–108, 2025, doi: 10.58854/jicm.1556194.
ISNAD Kaya, Gülsüm et al. “Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study”. Journal of Immunology and Clinical Microbiology 9/4 (January 2025), 101-108. https://doi.org/10.58854/jicm.1556194.
JAMA Kaya G, Ergenç Z, İncirkuş Küçük H, Ergenç H, Aksaray S. Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study. J Immunol Clin Microbiol. 2025;9:101–108.
MLA Kaya, Gülsüm et al. “Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study”. Journal of Immunology and Clinical Microbiology, vol. 9, no. 4, 2025, pp. 101-8, doi:10.58854/jicm.1556194.
Vancouver Kaya G, Ergenç Z, İncirkuş Küçük H, Ergenç H, Aksaray S. Evaluation of Antibiotic Consumption in Hospital: Single-Center Point Prevalence Study. J Immunol Clin Microbiol. 2025;9(4):101-8.

88x31.png 

Creative Commons Attribution Non-Commercial License: The articles in the Journal of Immunology and Clinical Microbiology are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

JICM is a product of QMEL® medicine & publishing