Assciation of Acetylcholinesterase and Butyrylcholinesterase Enzymes with Alzheimer's Disease

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that is mostly seen in the elderly population, is clinically characterized by memory and cognitive disorders, and causes irreversible damage to neuron cells. Many reasons such as the unknown causes of the disease, the increase in the number of patients with the increase in life expectancy, the decrease in the quality of life of the disease, and the high cost of treatment have increased the importance of the disease and directed researchers to this field. Although the etiology of the disease is not clarified, some hypotheses try to explain the cause of the disease. These are the cholinergic hypothesis, the amyloid hypothesis, the tau hypothesis, and the oxidative stress hypothesis. The cholinergic hypothesis is the only hypothesis that explains the cause of Alzheimer's disease and is still accepted. According to the cholinergic hypothesis, the decrease in the amount of acetylcholine, an important neurotransmitter that increases learning and cholinergic activity in the nervous system, causes Alzheimer's disease. Acetylcholine is synthesized by the cholineacetyltransferase (ChAT) enzyme in the nervous system, and hydrolyzed by Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzymes. In this study, the association of AChE and BChE cholinesterase enzymes with Alzheimer's disease was evaluated.

Keywords

• Alzheimer
• acetylcholine
• AChE
• BChE
• inhibitors

Asetilkolinesteraz ve Bütirilkolinesteraz Enzimlerinin Alzheimer Hastalığı ile İlişkisi

Abstract

Alzheimer hastalığı (AH) daha çok yaşlı popülasyonda görülen, klinik olarak hafıza ve bilişsel bozukluklar ile karakterize olan, geri dönüşümü olmayan nöron hücrelerinin hasarına yol açan bir nörodejeneratif hastalıktır. Hastalığının sebeplerinin tam olarak bilinmemesi, yaşama suresinin artmasıyla birlikte hasta sayısının gittikçe artması, hastalığın yaşam kalitesini çok fazla düşürmesi, tedavi maliyetinin çok yüksek olması gibi birçok neden hastalığın önemini artırmış ve araştırmacıların bu alana yönlendirmiştir. Hastalığın etiyolojisinin aydınlatılmamasına rağmen bazı hipotezlerle hastalığın nedeni açıklamaya çalışılmaktadır. Bunlar kolinerjik hipotez, amiloid hipotezi, tau hipotezi ve oksidatif stres hipotezidir. Kolinerjik hipotezi Alzheimer hastalığını nedenini açıklayan ve halen kabul gören tek hipotezdir. Kolinerjik hipoteze göre sinir sisteminde öğrenme ve kolinerjik aktiviteyi artıran önemli bir nörotransmiter olan asetilkolin miktarının azalması Alzheimer’e sebep olmaktadır. Asetilkolin sinir siteminde kolinasetiltransferaz (ChAT) enzimi tarafından sentezlenir, Asetilkolinesteraz (AChE) ve Bütirilkolinesteraz (BChE) enzimi tarafından hidroliz edilir. Bu çalışmada AChE ve BChE kolinesteraz enzimlerinin Alzheimer hastalığı ile ilişkisi değerlendirilmiştir.

Keywords

• AChE
• BChE
• Alzheimer hastalığı
• asetilkolin
• inhibitörler

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