Enzyme Inhibitory Properties and Antimicrobial Activity of Geranium tuberosum Methanol Extract

Abstract

Geranium tuberosum roots are consumed fresh in some areas of the countryside of Turkey. This study was conducted to scientifically validate the traditional use of the species. The enzyme inhibition effect and antimicrobial activity of the root and leaf parts of Geranium tuberosum were investigated using a methanol extract. The leaf extract had higher acetylcholinesterase and butyrylcholinesterase activity than the root extract, while the root extract showed a stronger inhibitory effect on xanthine oxidase enzyme.. Also, the antifungal and antibacterial activities of the extracts were investigated using the hollow agar technique. It was observed that both extracts gave high antimicrobial activity on different bacterial strains. These results confirmed that Geranium tuberosum is a natural antibacterial, and has enzyme inhibitory potential.

Keywords

• Geranium tuberosum
• Acetylcholinesterase
• Butyrylcholinesterase
• Xanthine Oxidase
• Antimicrobial

Thanks

The author is thankful to MAUN (Mus Alparslan University, Muş, Turkey) for providing laboratory facilities.

Geranium tuberosum Metanol Ekstraktının Enzim İnhibitör Özellikleri ve Antimikrobiyal Aktivitesi

Abstract

Geranium tuberosum kökleri Türkiye’de bazı kırsal bölgelerde taze olarak tüketilmektedir. Bu çalışma, türün geleneksel kullanımını bilimsel olarak ta aydınlatmak için yapılmıştır. Geranium tuberosum'un kök ve yaprak kısımlarının enzim inhibisyon etkisi ve antimikrobiyal aktivitesi, metanolik ekstraktlar kullanılarak araştırıldı. Yaprak ekstresi, kök ekstresine göre daha yüksek asetilkolinesteraz ve butirilkolinesteraz aktivitesine sahipken, kök ekstresi ksantin oksidaz enzimi üzerinde daha güçlü inhibitör etki gösterdi. Ayrıca ekstraktların antifungal ve antibakteriyel aktiviteleri içi boş agar tekniği kullanılarak araştırıldı. Her iki ekstraktın da farklı bakteri suşları üzerinde yüksek antimikrobiyal aktivite gösterdiği gözlendi. Bu sonuçlar Geranium tuberosum'un doğal bir antibakteriyel olduğunu ve enzim inhibe etme potansiyeline sahip olduğunu doğruladı.

Keywords

• Geranium tuberosum
• Asetilkolinesteraz
• Bütirilkolinesteraz
• Ksantin Oksidaz
• Antimikrobiyal

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