Screening of Inhibitory Effects Lanosterol on Butyrylcholinesterase, Acetylcholinesterase and Carbonic Anhydrase Enzymes

Year 2023, , 2838 - 2846, 01.12.2023

Eda Mehtap Üç

https://doi.org/10.21597/jist.1308662

Abstract

In this study, for the first time, the antiglaucoma and anticholinergic properties from lanosterol were appraised and researched using different bioanalytical methods and compared with standards. Lanosterol is the compound from which entire fungal and animal steroids are derived. Moreover, is a tetracyclic triterpenoid. Lanosterol is a component in over-the-counter ophthalmic products to prohibit cataracts. The inhibition effects of lanosterol were tested against the butyrylcholinesterase (BChE), carbonic anhydrase I and II (CA I and II) and acetylcholinesterase (AChE), which are associated with some global diseases like Alzheimer’s disease (AD) and glaucoma. Lanosterol were trialed for the inhibition of BChE, AChE, hCA I and II enzymes and indicated efficient inhibition profiles with Ki values in the range of 61.77±22.32 nM against hCA I, 101.11±49.74 nM against hCA II, 2.03±1.21 nM against acetylcholinesterase and 8.39±2.92 nM against butyrylcholinesterase.

Keywords

Lanosterol, Inhibition, CA I-II isoenzymes, Acetylcholinesterase, Butyrylcholinesterase

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