Gama ile Işınlanmış Etosüksimid Numunesinin Radyasyon Duyarlılığının Elektron Paramanyetik Rezonans Spektroskopisi Yöntemiyle İncelenmesi

Year 2019, , 800 - 810, 01.06.2019

Kerem Sütçü

https://doi.org/10.21597/jist.483268

Cited By: 1

Abstract

Bu çalışmanın amacı elektron paramanyetik rezonans spektroskopisi kullanılarak iyonize radyasyonun etosüksimid numunesinin radyasyon duyarlılığı üzerindeki etkilerini araştırmaktır. Işınlama sonrasında oluşan paramanyetik türlerin radyasyon duyarlılığını belirlemek maksadıyla, etosüksimid numunesine gama ışınları 1, 5, 10, 15, 20 ve 25 kiloGray dozlarında oda sıcaklığında uygulanmıştır. Numunenin sinyal şiddetlerinin mikrodalga güç fonksiyonuna bağlı değişimi 0.01-100 miliWatt aralığında incelenmiştir. Işınlanmış numunenin doz-cevap eğrilerini tanımlayan en yakın matematiksel denklemler belirlenmiştir. Absorbe edilen radyasyon dozuyla sinyal şiddetleri arasındaki korelasyon katsayıları hesaplanmıştır. Ölçümler gama ışımasıyla indüklenen serbest radikallerin dozimetrik özelliklerini incelemek için düşük ve yüksek sıcaklıklarda gerçekleştirilmiştir. Ayrıca, serbest radikallerin stabilitelerini incelemek için ışınlanmış numunenin sinyal şiddetlerinin zamana bağımlılığı analiz edilmiştir.

Keywords

Elektron paramanyetik rezonans, serbest radikal, gama ışınlaması

Supporting Institution

Dicle Üniversitesi DÜBAP

Project Number

ZGEF15007

Thanks

Bu çalışma, Dicle Üniversitesi DÜBAP ZGEF15007 numaralı proje kapsamında desteklenmiştir.

Investigation of Radiation Sensitivity of Gamma-Irradiated Ethosuximide Sample by Electron Paramagnetic Resonance Spectroscopy

Abstract

The purpose of this study is to investigate the effects of ionizing radiation on the radiation sensitivity of ethosuximide sample by using electron paramagnetic resonance spectroscopy. To determine the radiation sensitivity of the paramagnetic species formed after irradiation, gamma rays were applied to the ethosuximide sample at room temperature at doses of 1, 5, 10, 15 20, and 25 kiloGray. The intensities of signals of the sample as a function of microwave power were investigated in the range of 0.01-100 miliWatt. The closest mathematical equations that define the dose-response curves of the irradiated sample were determined. The correlation coefficients between the absorbed radiation dose and the signal intensities were calculated. Measurements were performed at low and high temperatures to study the dosimetric features of free radicals induced by gamma irradiation. Moreover time dependency of the intensity of the signals of the irradiated sample was analyzed to study the stability of the free radicals.

Keywords

Electron paramagnetic resonance, free radical, gamma irradiation

Project Number

ZGEF15007

References

• Ambroż HB, Kornacka EM, Marciniec B, Przybytniak G, 2002. Radical Decay in Irradiated Drugs: Flutamide, Ifosfamide. Journal of Radioanalytical and Nuclear Chemistry, 254 (2) : 293-298.
• Atasever MA, Atasever M, 2007. Işınlamanın Gıda Teknolojisinde Kullanımı. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 2: 107-116.
• Aydaş C, Engin BI, Polat M, Aydin T, 2008. Electron Spin Resonance Study of γ-Irradiated Anatolian Chickpea (Cicer Arietinum L.). Radiation Effects and Defects in Solids, 163 (1): 7-17.
• Basly, JP, Duroux JL, Bernard M, 1996. Radiosterilization Dosimetry by ESR Spectroscopy: Application to Terbutaline. International Journal of Pharmaceutics, 142 (2): 247-249.
• Basly JP, Bernard M, 1997. Radio Sterilization Dosimetry by ESR Spectroscopy: Ritodrine Hydrochloride and Comparison with Other Sympathomimetics. International Journal of Pharmaceutics, 149 (1): 85-91.
• Basly JP, Longy I, Bernard M, 1997. ESR Identification of Radiosterilized Pharmaceuticals: Latamoxef and Ceftriaxone. International Journal of Pharmaceutics, 158 (2): 241-245.
• Basly JP, Basly I, Bernard M, 1998a. Electron Spin Resonance Identification of Irradiated Ascorbic Acid: Dosimetry and Influence of Powder Fineness. Analytica Chimica Acta, 372 (3): 373-378.
• Basly JP, Basly I, Bernard M, 1998b. Influence of Radiation Treatment on Dobutamine. International Journal of Pharmaceutics, 170 (2): 265-269.
• Basly JP, Longy I, Bernard M, 1998c. Radiosterilization Dosimetry by Electron-Spin Resonance Spectroscopy: Cefotetan, Analytica Chim Acta, 359: 107-113.
• Başkan MH, Osmanoğlu YE, Sütçü K, Aydın M, Osmanoğlu Ş, 2015. Radiation Effect Studies in Single Crystal Of Trifluoroacetyl-α-Aminoisobutyric Acid. Radiation Effects and Defects in Solids, 170 (10): 854-861.
• Çolak S, 2010. ESR Identification of Gamma-Irradiated Albendazole. Radiation Effects and Defects in Solids: Incorporating Plasma Science and Plasma Technology, 165 (1): 72-82.
• Damian G, 2003. EPR Investigation of γ-Irradiated Anti-Emetic Drugs. Talanta, 60: 923-927.
• Desrosiers M.F, Le FG, Harewood PM, Josephson ES, Montesalvo M, 1993. Estimation of the Absorbed Dose in Radiation-Processed Food. 4. EPR Measurements on Eggshell. Journal of Agricultural and Food Chemistry, 41 (9): 1471-1475.
• Ghelawi MA, Moore JS, Bisby RH, Dodd NJ, 2001. Estimation of Absorbed Dose in Irradiated Dates (Phoenix Dactylifera L.). Test of ESR Response Function by a Weighted Linear Least-Squares Regression Analysis. Radiation Physics and Chemistry, 60 (1-2): 143-147.
• Gopal, NGS,1977. Radiation Sterilization of Pharmaceuticals and Polymers. Radiation Physics and Chemistry,12 (1-2): 35-50.
• Kurt ANC, 2018. Characteristics of the Knowledge and Attitudes Of Parents About Epilepsy. Epilepsy and Behavior, 86:153-156.
• Murrieta HS, Munoz EP, Adem E, Burillo G, Vazquez M, Cabrera EB, 1996. Effect of Irradiation Dose, Storage Time and Temperature on the ESR Signal in Irradiated Oat, Corn and Wheat. Applied Radiation and Isotopes, 47 (11-12): 1657-1661.
• Naskrent M, Mielcarek J, 2007. The Effect Of Ionizing Radiation of 1, 4-Dihydropyridine Derivatives in the Solid State. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 67 (1): 251-255.
• Nishikawa T, Abe N, Yonesu A, Hayashi N, 2018. Sterilization of Small Vial Using Electron Cyclotron Resonance Plasma. Vacuum, 157: 100-104.
• Osmanoğlu Ş, Aydın M, Başkan MH, 2005. EPR of Gamma-Irradiated L-Glutamine Hydrochloride and N-Carbamoyl-L-Glutamic Acid. Zeitschrift für Naturforschung A, 60 (7): 549-553.
• Sütçü K, 2018a. EPR Investigation of Damage Centers Formed in Some Drug Powders Irradiated with Gamma Rays. Journal of Molecular Structure, 1163: 1-3.
• Sütçü K, 2018b. Gama İle Işınlanmış Amantadin Hidroklorürde Oluşan Serbest Radikallerin Simülasyon Metoduyla İncelenmesi. DÜMF Mühendislik Dergisi, 9(2): 829-836.(2018b)
• Sütçü K, Osmanoğlu YE, 2018. Electron Spin Resonance Identification of Gamma İrradiated 2, 4′-Dichlorodiphenyl Dichloroethane and 6-Mercaptopurine Monohydrate in the Solid State. Journal of Molecular Structure, 1174: 67-73.
• Yürüş S, 2010. Radyasyonla Sterilize Edilen Sefem Grubu Bazı Antibiyotiklerde Oluşan Radyolitik Araürünlerin Karakterizasyonu, Hacettepe Üniversitesi Fen bilimleri Enstitüsü, Doktora Tezi (Basılmış).