Antihypertensive Drug Atenolol Selective Potentiometric Microsensor

Year 2019, , 1528 - 1538, 01.09.2019

Murat Yolcu , Nihal Yardım Çelik

https://doi.org/10.21597/jist.535564

Abstract

In this study, all solid-state type potentiometric PVC membrane selective microsensor was developed for atenolol which is an antihypertensive drug active substance. Atenolol-tetraphenylborate ion-pair was used as an ionophore in the structure of the sensor membrane. It was determined that the sensor membrane at the ratio of 62% dioctyl sebacate, 30% polyvinyl chloride and 4% ion-pair performed the best potentiometric performance. In a wide concentration range (5x10-5-1x10-2 mol L-1), the slope, detection limit, pH range, response time, and life-time of the sensor were determined as 36.6±2.6 mV (R2=0.996), 1.26 x10-5 mol L-1, pH:3-8, 10-12 s, and ~6 weeks, respectively. The prepared microsensor was successfully utilized for the determination of atenolol in pharmaceutical drug sample. It was observed that the obtained results were in agreement with the results obtained by the UV method at 95% confidence level.

Keywords

Antihypertensive, atenolol, potentiometric sensor, spectroscopy

Antihipertansif İlaç Atenolole Seçici Potansiyometrik Mikrosensör

Abstract

Bu çalışmada antihipertansif bir ilaç etken madde olan atenolol için tümüyle katı-hal tipi potansiyometrik PVC membran seçici mikrosensör geliştirildi. Sensörün membran yapısı içerisinde iyonofor madde olarak atenolol-tetrafenilborat iyon çifti kullanıldı. Ağırlıkça % 62 dioktil sebekat, % 30 polivinil klorür ve % 8 iyon-çiftinden oluşan membran bileşimine sahip atenolol-seçici sensörün en iyi performansı sergilediği belirlendi. Geniş doğrusal çalışma aralığında (5x10-5-1x10-2 mol L-1), sensörün eğim değeri 36.6±2.6 mV (R2=0.996), tayin limiti 1.26 x10-5 mol L-1, pH çalışma aralığı 3-8, cevap zamanı 10-12 s ve kullanım ömrü yaklaşık 6 hafta olarak belirlendi. Hazırlanan mikrosensör kullanılarak farmasötik ilaç numunesinin içerdiği atenolol miktarı başarıyla tayin edildi. Elde edilen sonuçların % 95 güven seviyesinde UV metodu ile elde edilen sonuçlarla uyum içerisinde olduğu görüldü.

Keywords

Antihipertansif, atenolol, potansiyometrik sensör, spektroskopi

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