Synthesis of Some Symmetrical and Non-Symmetrical Urea Derivatives of Substituted Phenethylamines

Abstract

In this study, some symmetrical and non-symmetrical urea derivatives (13-22) have been synthesized from substituted phenethylamines (8-12) with carbonyldiimidazole (CDI) under mild conditions. For this purpose, substituted phenethylamines were reacted with carbonyldiimidazole in water, and after the formation of the imidazolide intermediate, the corresponding products (13-22) have been synthesized in yields between 43% - 66% by giving a second substituted phenethylamine (8-12). For this purpose, substituted phenethylamines were reacted with carbonyldiimidazole in water, and after the formation of the imidazolide intermediate, the corresponding products (13-22) have been synthesized in yields between 43% - 66% by giving a second substituted phenethylamine (8-12).

Keywords

• Symmetrical urea
• non-symmetrical urea
• substituted phenethylamine
• carbonyldiimidazole

Sübstitüe Fenetilaminlerin Bazı Simetrik ve Asimetrik Üre Türevlerinin Sentezi

Abstract

Bu çalışmada, sübstitüe fenetilaminlerden (8-12) karbonildiimidazol (CDI) ile ılıman şartlarda simetrik ve asimetrik bazı üre türevleri (13-22) sentezlenmiştir. Bunun için öncelikle sübstitüe fenetilaminler karbonildiimidazol ile su içerisinde reaksiyona sokulmuş ve imidazolid ara ürününün oluşmasından sonra ikinci bir sübstitüe fenetilamin (8-12) verilerek hedef ürünler (13-22) % 43 - % 66 arasında verimlerle sentezlenmiştir. Bunun için öncelikle sübstitüe fenetilaminler karbonildiimidazol ile su içerisinde reaksiyona sokulmuş ve imidazolid ara ürününün oluşmasından sonra ikinci bir sübstitüe fenetilamin (8-12) verilerek hedef ürünler (13-22) % 43 - % 66 arasında verimlerle sentezlenmiştir.

Keywords

• Simetrik üre
• asimetrik üre
• sübstitüe fenetilamin
• karbonildiimidazol

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