Farmasötik Preparatlarda Ondansetron Tayini İçin Elektrokimyasal Sensör Geliştirilmesi

Abstract

Bu çalışmada, farmasötik preparatlardaki ondansetron içeriğinin belirlenmesi için karbon nanotüp immobilize diester-kaliks[4]arene (CNT-Calix-DE) dayalı elektrokimyasal sensör geliştirildi. Sensör hazırlama aşamasında, camsı karbon elektrot yüzeyi CNT-Calix-DE ile modifiye edildi. Sensörün yüzey morfolojisi, elektrokimyasal karakterizasyonu ve analitik performansı, taramalı elektron mikroskopu (SEM), elektrokimyasal empedans spektroskopisi (EIS) ve diferansiyel puls anodik sıyırma voltametrisi (DPASV) kullanılarak incelendi. Optimum deneysel koşullar altında, geliştirilen sensör ondansetrona karşı 1.0-10.0 µM konsantrasyon aralığında doğrusal cevap gösterdi. Sensörün analitik uygulanabilirliği farmasötik preparatlarda ondansetron tayini yapılarak araştırıldı.

Keywords

• ondansetron
• sensör
• farmasötik preparat

Development of Electrochemical Sensor for Determination of Ondansetron in Pharmaceutical Preparations

Abstract

In this study, an electrochemical sensor based on carbon nanotube immobilized with diester-functionalized calix[4]arene (CNT-Calix-DE) was developed to determine the ondansetron content in pharmaceutical preparations. During the sensor preparation stage, the glassy carbon electrode surface was modified with CNT-Calix-DE. The surface morphology, electrochemical characterization and analytical performance of the sensor were examined using scanning electron microscope (SEM), electrochemical impedance spectroscopy (EIS) and differential pulse anodic stripping voltammetry (DPASV). Under optimal experimental conditions, the developed sensor showed a linear response to ondansetron in the concentration range of 1.0-10.0 M. Analytical applicability of the sensor was investigated by determination of ondansetron in pharmaceutical preparations.

Keywords

• ondansetron
• sensor
• pharmaceutical preparations

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