Yeni Tiofen Türevlerin Sentezlenmesi ve Karakterizasyonu

Year 2019, Volume: 9 Issue: 1, 111 - 120, 01.03.2019

Adnan Çetin , Havva Kurt Sedat Bozarı

https://doi.org/10.21597/jist.422537

Cited By: 1

Abstract

Kararlı bir yapıya sahip tiyofen türevlerinin ziraat, gıda ve ilaç sanayilerinde kullanımı farklı türevlerinin sentezlenmesi gerekliliğini ortaya koymuştur. Bu amaçla, mevcut çalışmada bazı substitüe tiofen türevleri tasarlanıp sentezlendi. Sentezlenen bileşiklerin karakterizasyonu, spektroskopik yöntemlerle belirlendi. Bu bileşiklerin (3-9, 10a-e, 11-13) olası antimikrobiyal aktiviteleri gram pozitif (Bacillus subtilis ATCC 6633, Staphylococcus aureus 6538) ve gram negatif (Enterobacter aerogenes ATCC 13048, Escherichia coli) bakterilere karşı disk difüzyon metodu ile ölçüldü. Sentezlenen substitüe tiofen bileşiklerinin test bakterilerine karşı herhangi bir aktivite göstermediği belirlendi.

Keywords

Heterosiklik bileşikler, hidrazid, tiofen, okzadiazol, pirazol

Synthesis and Characterization of the Novel Thiophene Derivatives

Abstract

The use of thiophene derivatives that have a stable structure in agriculture, food and pharmaceutical industries has revealed the necessity of synthesizing different derivatives. For this purpose, in the current study, some substituted thiophene derivatives have been designed and synthesized. The characterization of the synthesized compounds was determined by spectroscopic methods. The possible antimicrobial activities of these compounds (3-9, 10a-e, 11-13) were measured by disc diffusion method against gram positive (Bacillus subtilis ATCC 6633, Staphylococcus aureus 6538) and gram negative (Enterobacter aerogenes ATCC 13048, Escherichia coli) bacteria. The synthesized substituted thiophene compounds do not showed any antibacterial activities against test bacteria.

Keywords

Heterocyclic compounds, hydrazide, thiophene, oxadiazole, pyrazole

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