Synthesis and Antifungal Activity of New Nitrobenzofuran Derivatives

Year 2019, Volume: 9 Issue: 2, 967 - 974, 01.06.2019

Ahmet Çağrı Karaburun

https://doi.org/10.21597/jist.480052

Abstract

The object of present study is to assess anticandidal activities of some new aryl (5-nitrobenzofuran-2-yl)keton and ketoxime compounds. Eight aryl (5-nitrobenzofuran-2-yl)ketones and ketoximes were synthesized. IR, 1H-NMR and HR-MS spectroscopic data, performed the structure elucidation of the synthesized compounds. Anticandidal activities of the all synthesized compounds were studied. Compound 2c bearing methoxy group on phenyl ring showed the highest activity with MIC value of 3.12 μg mL-1 against Candida albicans and Candida glabrata. None of the compounds activity results were equal to or better than that of the control compounds ketoconazole and fluconazole. However, compound 2c displayed a promising anticandidal activity.

Keywords

Aryl (5-nitrobenzofuran-2-yl)ketones, aryl (5-nitrobenzofuran-2-yl)ketoximes, anticandidal activity

Supporting Institution

Anadolu University Scientific Projects Fund

Project Number

1807S253

Thanks

Financial contribution of Anadolu University Scientific Projects Fund (Project No.: 1807S253) is gratefully acknowledged.

Yeni Nitrobenzofuran Türevlerinin Sentezi ve Antifungal Etkileri

Abstract

Bu çalışmada bazı yeni aril (5-nitrobenzofuran-2-il)keton ve ketoksim bileşiklerinin antikandidal etkinliklerinin değerlendirilmesi amaçlanmıştır. Sekiz aril (5-nitrobenzofuran-2-il)keton ve ketoksimi sentezlenmiştir. Sentezlenen bileşiklerin yapı aydınlatmaları IR, 1H-NMR ve HR-MS spektroskopik verileri ile gerçekleştirilmiştir. Bileşiklerin antikandidal etkinlikleri incelenmiştir. Fenil halkası üzerinde metoksi grubu taşıyan bileşik 2c, 3.12 μg mL-1 MİK değeri ile Candida albicans ve Candida glabrata’ya karşı en yüksek aktiviteyi göstermiştir. Hiçbir bileşik kontrol bileşikleri olan ketokonazol ve flukonazole eş ya da daha iyi aktivite sergileyememiştir. Ancak, bileşik 2c’nin aktivite sonuçları umut verici olarak değerlendirilmektedir.

Keywords

Aril (5-nitrobenzofuran-2-il)ketonlar, aril (5-nitrobenzofuran-2-il)ketoksimler, antikandidal aktivite

Project Number

1807S253

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