Year 2020, Volume 10 , Issue 1, Pages 357 - 367 2020-03-01

Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology
Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology

Mustafa BENER [1]


In this study, modelling and optimizing microwave-assisted extraction (MAE) of antioxidants and phenolics from wormwood (Artemisia absinthium L.) was performed by using response surface methodology with face-centered composite design as factors of temperature, extraction time, solvent concentration, and solid-to-solvent ratio. The MAE process factors were optimized so that cupric reducing antioxidant capacity (CUPRAC) and total phenolic content (TPC) of the wormwood extract are maximized. All of the models calculated for the two responses (CUPRAC and TPC) were found significant (p<0.0001) to show the relationship between the response and independent parameters. Extraction temperature was found as the most significant operational factor in MAE. Extraction time was found is the most insignificant parameter in MAE. The data obtained by the experimental model and the predicted by the model were found to be strongly accordance. It shows the suitability of the model and its success in optimization. The CUPRAC and TPC yields were obtained as 1.22 and 1.42 mmol TR/g-dried sample under the optimum operational conditions of MAE. According to the CUPRAC and TPC values, under the same operational conditions, MAE method was found to be approximately two times more efficient than classical heat extraction. As a result, the modeled methodology can be applied to the extraction of antioxidant and phenolics from the wormwood in the natural product industry.

In this study, modelling and optimizing microwave-assisted extraction (MAE) of antioxidants and phenolics from wormwood (Artemisia absinthium L.) was performed by using response surface methodology with face-centered composite design as factors of temperature, extraction time, solvent concentration, and solid-to-solvent ratio. The MAE process factors were optimized so that cupric reducing antioxidant capacity (CUPRAC) and total phenolic content (TPC) of the wormwood extract are maximized. All of the models calculated for the two responses (CUPRAC and TPC) were found significant (p<0.0001) to show the relationship between the response and independent parameters. Extraction temperature was found as the most significant operational factor in MAE. Extraction time was found is the most insignificant parameter in MAE. The data obtained by the experimental model and the predicted by the model were found to be strongly accordance. It shows the suitability of the model and its success in optimization. The CUPRAC and TPC yields were obtained as 1.22 and 1.42 mmol TR/g-dried sample under the optimum operational conditions of MAE. According to the CUPRAC and TPC values, under the same operational conditions, MAE method was found to be approximately two times more efficient than classical heat extraction. As a result, the modeled methodology can be applied to the extraction of antioxidant and phenolics from the wormwood in the natural product industry.

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Primary Language en
Subjects Engineering, Chemical
Published Date Mart-2020
Journal Section Kimya / Chemistry, Kimya Mühendisliği / Chemical Engineering
Authors

Orcid: 0000-0002-2699-1354
Author: Mustafa BENER (Primary Author)
Institution: Istanbul University-Cerrahpasa
Country: Turkey


Dates

Application Date : July 5, 2019
Acceptance Date : September 23, 2019
Publication Date : March 1, 2020

Bibtex @research article { jist587756, journal = {Journal of the Institute of Science and Technology}, issn = {2146-0574}, eissn = {2536-4618}, address = {}, publisher = {Igdir University}, year = {2020}, volume = {10}, pages = {357 - 367}, doi = {10.21597/jist.587756}, title = {Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology}, key = {cite}, author = {BENER, Mustafa} }
APA BENER, M . (2020). Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology. Journal of the Institute of Science and Technology , 10 (1) , 357-367 . DOI: 10.21597/jist.587756
MLA BENER, M . "Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology". Journal of the Institute of Science and Technology 10 (2020 ): 357-367 <https://dergipark.org.tr/en/pub/jist/issue/52503/587756>
Chicago BENER, M . "Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology". Journal of the Institute of Science and Technology 10 (2020 ): 357-367
RIS TY - JOUR T1 - Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology AU - Mustafa BENER Y1 - 2020 PY - 2020 N1 - doi: 10.21597/jist.587756 DO - 10.21597/jist.587756 T2 - Journal of the Institute of Science and Technology JF - Journal JO - JOR SP - 357 EP - 367 VL - 10 IS - 1 SN - 2146-0574-2536-4618 M3 - doi: 10.21597/jist.587756 UR - https://doi.org/10.21597/jist.587756 Y2 - 2019 ER -
EndNote %0 Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology %A Mustafa BENER %T Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology %D 2020 %J Journal of the Institute of Science and Technology %P 2146-0574-2536-4618 %V 10 %N 1 %R doi: 10.21597/jist.587756 %U 10.21597/jist.587756
ISNAD BENER, Mustafa . "Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology". Journal of the Institute of Science and Technology 10 / 1 (March 2020): 357-367 . https://doi.org/10.21597/jist.587756
AMA BENER M . Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology. Iğdır Üniv. Fen Bil Enst. Der.. 2020; 10(1): 357-367.
Vancouver BENER M . Modeling and Optimizing of Microwave-Assisted Extraction of Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.) Using Response Surface Methodology. Journal of the Institute of Science and Technology. 2020; 10(1): 367-357.