Bazı Yeni 1,2,3-Triazol-arilidenhidrazid Hibrit Bileşiklerinin Sentezi ve Anti-mikrobiyal Etkinliklerinin Belirlenmesi

Year 2023, Volume: 13 Issue: 1, 468 - 481, 01.03.2023

Halil Şenol , Harika Öykü Dinç , Beyza Nur Tak

https://doi.org/10.21597/jist.1177747

Abstract

Günümüzde kansere ve diğer mikroorganizmalara karşı kullanılan ilaçların pek çoğunun
biyoyararlanımının düşük olması ve başta toksisite gibi yan etkilerinden dolayı tedavide yeni
ilaçların varlığına ihtiyaç duyulmaktadır. Her gün artan sayıda anti-kanser veya antibiyotik
ilaç geliştirilmesine rağmen, bu ilaçların seçiciliklerinin düşük olması ve çoklu ilaç
direncinin kazanılması, başarılı bir tedavinin önüne geçmektedir. Bu nedenle, tümör
hücrelerini veya mikroorganizmaları yok etmek veya en azından çoğalmasını durdurmak için
yeni, güçlü ve seçici ajanlarının keşfine önemli ölçüde ihtiyaç duyulmaktadır. Bu çalışma
kapsamında 18 adet yeni 1,2,3-triazol/arilidenhidrazid yapısında hibrit bileşik sentezlendi.
Elde edilen 18 yeni bileşiğin (17a-r) Staphylococcus Aureus ve Escheric1hia coli bakteri
türleri ve Candida albicans mantar türü üzerindeki anti-mikrobiyal etkinlikleri araştırıldı.
Elde edilen sonuçlar anti-mikrobiyal ilaç seftazidim ile karşılaştırıldı. Bileşiklerin anti fungal
etkinliklerinin MİK değerleri 62.5 μM olarak bulunurken anti-bakteriyel etkinliklerinin MİK
değerleri 62.5-125 μM olarak belirlendi.

Keywords

1,2,3-triazol, Hibrit bileşik, Arilidenhidrazid, Anti-mikrobiyal, Organik sentez

Supporting Institution

TÜBİTAK

Project Number

2209A - 1919B012100494

Synthesis of Some New 1,2,3-Triazole-Arylidenehydrazide Hybrid Compounds and Determination of Their Antimicrobial Activities

Abstract

At the present time, due to the low bioavailability of many of the drugs used against cancer
and other microorganisms and their side effects such as toxicity, there is a need for new
drugs in the treatment. Although an increasing number of anticancer or antibiotic drugs are
being developed every day, the low selectivity of these drugs and the acquisition of multidrug
resistance prevent successful treatment. Therefore, there is a great need for the
discovery of new, potent and selective agents to destroy or at least stop the proliferation of
tumor cells or microorganisms. In this study, 18 new 1,2,3-triazole/arylidenehydrazide
hybrid compounds were synthesized. Anti-microbial activities of these compounds (17a-r)
were investigated on Staphylococcus Aureus and Escherichia coli and Candida albicans.
The results were compared with the anti-microbial drug ceftazidime. The MIC values of the
anti-fungal activities of the compounds were found as 62.5 μM, while the MIC values of the
anti-bacterial activities were determined as 62.5-125 μM.

Keywords

1,2,3-triazole, Hybrid Compound, Arylidenehydrazide, Anti-microbial, Organic synthesis

Project Number

2209A - 1919B012100494

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