Balık İmmünolojisi, Bitkisel ve Kimyasal İmmünostimulantlar

Year 2011, Volume: 1 Issue: 4, 69 - 76, 31.12.2011

Başar Altınterim

Abstract

Son yıllarda balıkların immün sisteminin anlaşılması ve detaylı izah edilmesinde önemli araştırmalar yapılmıştır. İmmün sistem, balıkların enfeksiyonlara karşı koymasında ve sağlıklılığının sürdürülmesinde önemlidir. Balık türlerinin üretimini yapan balık çiftliklerinde ciddi hastalık problemleri önlenmelidir. İmmünostimulantlar, hem spesifik hem de spesifik olmayan bağışıklık sistemlerinin gelişmesine bağlı olarak enfeksiyöz hastalıklara karşı direnci artırmaktadır. Kültür yetiştiriciliği uygulanan balıklarda enfeksiyonları yok etmek için kimyasal immünostimulantlar kullanılmıştır. Bunun sonucunda yetiştiricilik yapılan yerlerde ilaca dirençli bakterilerin artışı görülmüştür. Fakat en son çalışmalarda balık hastalıklarının tedavisi ve bağışıklık sistemlerini güçlendirmek için bitkilerden elde edilen ürünlerin kullanımı çok etkili olmuştur. Bitkisel immünostimulantlar yan etkisizdir ve son zamanlarda organik tarımda kullanılmaktadır

Keywords

Balık immünolojisi, bitkisel immünostimulantlar, kimayasal immünostimulantlar

Fish Immunology, Herbal And Chemical Immunostimulants

Abstract

In recent years considerable progress has been made in describing and understanding the immune

system of fish. The immune system is essential in the defence against infections, as well as in maintaining good

health, in all developmental stages of fish. The farming of fish species is hampered by serious disease problems.

Immunostimulants increase resistance to infectious diseases by enhancing both specific and non-specific defense

mechanisms. Use of chemical immunostimulants has been used to treat infections in cultured fish, and the emergence

of drug-resistant bacteria has become a major problem in fish culture. But, in recent investigates, the use of

products obtained from plants for treatment fish diseases and enhanced immunity as immunostimulant is became

very efficacious Herbal immünostimulants haven not got side effects, and is used in organic agriculture nowadays.

Keywords

Fish immunolgy, herb immunostimulants, chemical immunostimulants

References

• Abbas, A.K., Lichtman, A.H., 2007. Temel İmmünoloji, İstanbul Medikal Yayıncılık, Editörler: Prof. Dr. Yıldız Camcıoğlu, Prof. Dr. Günnur Deniz. 1–223 s.
• Akaylı, T., 2001. Kültür Çipura Balıklarında (Sparus auratus, L 1758) Vibriosis’in ELISA ve Bakteriyolojik Yöntemlerle Teşhisi. İstanbul Üniversitesi Fen Bilimleri Enstitüsü. Su Ürünleri Yetiştiriciliği Ana Bilim Dalı (Hastalıklar Bilim Dalı). Doktora Tezi.
• Alberto, C., Alejandro, R., Angeles, E., Jose, M., 2005. İn vivo effects of propolis, a honey bee product, on gill head seabream innate immune responses Fish & Shellfish Immunology 18, 71–80pp.
• Altınterim, B., 2010. “Çörekotu (Nigella sativa) yağının Gökkuşağı alabalığı (Oncorhynchus mykiss)’nın bağışıklık sistemine etkileri”. Fırat Üniversitesi Fen Bilimleri Enstitüsü Doktora tezi. Fırat Üniversitesi. Elazığ.
• Anderson, D.P., 1992. Immunostimulants, adjuvants and receive carriers in fish: applications to aquaculture. Ann. Rev. Fish Dis. 2, 281–307 pp.
• Aoki, T., 1992. Chemotherapy and drug resistance in fish farms in Japan. Diseases in Asian Aquaculture, vol. 1. Fish Health Section. Asian Fisheries Society, Manila, Philippines, 519 – 529 pp.
• Arda, M., Seçer, S., Sarıeyyüpoğlu, M., 2002. Balık Hastalıkları, Medisan Yayınevi, Ankara, 1-36 s.
• Buonocore, F., Randelli, E., Bird, S., Secombes, C.J., Facchiano, A., Costantini, S., 2007. Interleukin–10 expression by real–time PCR and homology modelling analysis in the European sea bass (Dicentrarchus Labrax L.). Aquaculture. 270, 512–522 pp.
• Danilova, N., Bussmann, J., Jekosch, K., Szteiner, L.A., 2005. The immunoglobulin heavy–chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z. Nat. Immunol. 6, 295–302 pp.
• Das, B.K., Nayak, K.K., Fourrier, M., Collet, B., Snow, M., Ellis, A.E., 2007. Expression of Mx protein in tissues of Atlantic salmon postsmoltse an immunohistochemical study. Fish Shellfish Immunol. 23, 1209–1217 pp.
• Delaquis, P.J., Stanich, K., Girard, B., Mazza, G., 2002. Antimicrobial activity of individual and mixed fractions of dill, cilantro, black cumin and eucalyptus essential oils. Int. J. Food Microbiol. 25, 74(1–2), 101–109 pp.
• Dügenci, S.K., Arda, N., Candan, A., 2003. Some medicinal plants as immunostimulant for fish. Journal of Ethnopharmacology. 88, 99–106 pp.
• Erganiş, O., İstanbulluoğlu, E., 1993. İmmünoloji. 17–54 s.
• Evans, D.L., Leary, J.H., Jaso–Friedmann, L., 1999. An antigen receptor (NCCRP–1) on nonspecific cytotoxic cells is a phosphoprotein associated with the JAK–STAT activation pathway. Cell Signal. 11, 287–292 pp.
• Findlay, V.L., Munday, B.L., 2000, Immunomodulatory effects of levamisole on the nonspecific immune system of Atlantic salmon, Salmo salar L. Journal of Fish Diseases. 23, 369 – 378 pp.
• Guojun Y., Galina J., Timea R., Pao X., Xie J., Zsigmond J., 2006. Freshwater Fisheries Research Center of Chinese Academy of Fishery Sciences. Quitang 1, Wuxi, 214081, China. Effect of two Chinese herbs (Astragalus radix and Scutellaria radix) on non-specific immune response of tilapia, Oreochromis niloticus. Aquaculture. 253, 39-47 pp.
• Guselle, N.J., Markham, R.J.F., Speare, D.J., 2006. Intraperitoneal afministration of β–1,3/1,6–glucan to rainbow trout, Oncorhynchus mykiss (Walbaum), protects against Loma salmonae. Vet. Immunol. Immunopathol.29, 375–381 pp.
• Hansen, J.D., Kaattari, S.L., 1996. The recombination activating gene 2 (RAG2) of the rainbow trout (Oncorhynchus mykiss). Immunogenetics. 44, 203–211 pp.
• Kearn, G.C., 1976. Body surface of fishes. In: Ecological aspects of parasitology. (Ed. Kennedy, C. R.). Amsterdam, The Netherlands: North-Holland Publishing Company. 185-208 pp.
• Kitao, O.T., Yoshida, T., 1986. Effect of an immunopotentiator on Aeromonas salmonicida infection in rainbow trout (Salmo gairdneri). Vet. Immunol. Immunopathol. 12, 287–291 pp.
• Kitao, T., Yoshida, T., Anderson D.P., Dixon, O.W., Blanch, A., 1987. Immunostimulation of antibody–producing cells and humoral antibody to fish bacterin by a biological response modifier. J. Fish Biol. 31, 87–91pp.
• Kumari, J., Sahoo, P.K., 2006. Non–specific immune response of healthy and immunocompromised Asian catfish (Clarias batrachus) to several immunostimulants. Aquaculture. 255, 133-141 pp.
• Magnadottir, B., Lange, S., Gudmundsdottir, S., Bøgwald, J., Dalmo, R.A., 2005. Ontogeny of humoral immune parameters in fish. Fish Shellfish Immunol. 19, 429–439 pp.
• Magnadottir, B., 2006. Innate immunity of fish (overview). Fish and Shellfish Immunology. 20, 37–151 pp.
• Poppenga, R.H., 2002. Herbal medicine: Potential for intoxication and interaction with conventional drugs. Clinical Techniques in Small Animal Practice 17, 6–18 pp.
• Randelli, E., Buonocore, F., Scapigliati, G., 2008. Cell markers and determinants in fish immunology. Fish & Shellfish Immunology. 25, 326 p.
• Rijkers, G.T., Teunissen, A.G., Van Oosterom, R., Van Muiswinkel, W.B., 1980. The immune system of cyprinid fish. The immunosuppresive effect of the antibiotic oxytetracycline in carp. Aquaculture. 19, 177–189 pp.