Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever

Volume: 1 Number: 03 September 1, 2011
  • Sami Kınıklı
  • Neziha Yılmaz
  • Salih Cesur
  • Ahmet Aydemir
  • Hasan Irmak
  • Cemal Bulut
  • Ali Pekcan Demiröz
  • Gülay Kınıklı
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Journal of Microbiology and Infectious Diseases
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Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever

Abstract

Objectives: Crimean-Congo hemorrhagic fever (CCHF) is a tick borne zoonotic infection. Up till now knowledge about pathogenesis of the disease is limited. Cytokine response is quite important during this infection. The aim of this study was to determine the serum tumor necrosis factor-alpha (TNF-&alpha;) and the interleukin-4 (IL-4) levels in patients with CCHF and compare with those of healthy controls. Materials and methods: Forty-two adult CCHF patients and 40 healthy subjects were included in this study. The diagnosis of CCHF was based upon anti-CCHF virus IgM positivity (ELISA method), and/or positivity in real time-polymerase chain reaction (RT-PCR) in acute phase serum samples. Serum TNF-&alpha; and IL-4 levels were determined by ELISA method. Results: In patients with CCHF the mean serum TNF-&alpha; level was significantly higher than the control group (15.01 vs. 7.69 pg/ml; p<0.05) and also the mean serum IL-4 levels were significantly higher than the control group (1.07 vs. 0 pg/ml; p<0.05). Conclusion: The levels of serum TNF-&alpha; and IL-4 in CCHF patients were found higher than healthy controls. These cytokines might play an important role in the pathogenesis of CCHF.

Keywords

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Sami Kınıklı This is me

Neziha Yılmaz This is me

Salih Cesur This is me

Ahmet Aydemir This is me

Hasan Irmak This is me

Cemal Bulut This is me

Ali Pekcan Demiröz This is me

Gülay Kınıklı This is me

Publication Date

September 1, 2011

Submission Date

April 30, 2015

Acceptance Date

-

Published in Issue

Year 2011 Volume: 1 Number: 03

DOI

https://doi.org/10.5799/ahinjs.02.2011.03.0030

IZ

https://izlik.org/JA27EA56JK

Cite

RIS / Bibtex
APA
Kınıklı, S., Yılmaz, N., Cesur, S., Aydemir, A., Irmak, H., Bulut, C., Demiröz, A. P., & Kınıklı, G. (2011). Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases, 1(03). https://doi.org/10.5799/ahinjs.02.2011.03.0030
AMA
1.Kınıklı S, Yılmaz N, Cesur S, et al. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. J Microbil Infect Dis. 2011;1(03). doi:10.5799/ahinjs.02.2011.03.0030
Chicago
Kınıklı, Sami, Neziha Yılmaz, Salih Cesur, et al. 2011. “Serum Tumor Necrosis Factor Alpha and Interleukin-4 Levels in Patients With Crimean-Congo Hemorrhagic Fever”. Journal of Microbiology and Infectious Diseases 1 (03). https://doi.org/10.5799/ahinjs.02.2011.03.0030.
EndNote
Kınıklı S, Yılmaz N, Cesur S, Aydemir A, Irmak H, Bulut C, Demiröz AP, Kınıklı G (September 1, 2011) Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases 1 03
IEEE
[1]S. Kınıklı et al., “Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever”, J Microbil Infect Dis, vol. 1, no. 03, Sept. 2011, doi: 10.5799/ahinjs.02.2011.03.0030.
ISNAD
Kınıklı, Sami - Yılmaz, Neziha - Cesur, Salih - Aydemir, Ahmet - Irmak, Hasan - Bulut, Cemal - Demiröz, Ali Pekcan - Kınıklı, Gülay. “Serum Tumor Necrosis Factor Alpha and Interleukin-4 Levels in Patients With Crimean-Congo Hemorrhagic Fever”. Journal of Microbiology and Infectious Diseases 1/03 (September 1, 2011). https://doi.org/10.5799/ahinjs.02.2011.03.0030.
JAMA
1.Kınıklı S, Yılmaz N, Cesur S, Aydemir A, Irmak H, Bulut C, Demiröz AP, Kınıklı G. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. J Microbil Infect Dis. 2011;1. doi:10.5799/ahinjs.02.2011.03.0030.
MLA
Kınıklı, Sami, et al. “Serum Tumor Necrosis Factor Alpha and Interleukin-4 Levels in Patients With Crimean-Congo Hemorrhagic Fever”. Journal of Microbiology and Infectious Diseases, vol. 1, no. 03, Sept. 2011, doi:10.5799/ahinjs.02.2011.03.0030.
Vancouver
1.Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiröz, Gülay Kınıklı. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. J Microbil Infect Dis. 2011 Sep. 1;1(03). doi:10.5799/ahinjs.02.2011.03.0030

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