Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever

Cilt: 1 Sayı: 03 1 Eylül 2011
  • Sami Kınıklı
  • Neziha Yılmaz
  • Salih Cesur
  • Ahmet Aydemir
  • Hasan Irmak
  • Cemal Bulut
  • Ali Pekcan Demiröz
  • Gülay Kınıklı
Journal of Microbiology and Infectious Diseases Kapak
Journal of Microbiology and Infectious Diseases
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Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever

Abstract

Objectives: Crimean-Congo hemorrhagic fever (CCHF) is a tick borne zoonotic infection. Up till now knowledge about pathogenesis of the disease is limited. Cytokine response is quite important during this infection. The aim of this study was to determine the serum tumor necrosis factor-alpha (TNF-&alpha;) and the interleukin-4 (IL-4) levels in patients with CCHF and compare with those of healthy controls. Materials and methods: Forty-two adult CCHF patients and 40 healthy subjects were included in this study. The diagnosis of CCHF was based upon anti-CCHF virus IgM positivity (ELISA method), and/or positivity in real time-polymerase chain reaction (RT-PCR) in acute phase serum samples. Serum TNF-&alpha; and IL-4 levels were determined by ELISA method. Results: In patients with CCHF the mean serum TNF-&alpha; level was significantly higher than the control group (15.01 vs. 7.69 pg/ml; p<0.05) and also the mean serum IL-4 levels were significantly higher than the control group (1.07 vs. 0 pg/ml; p<0.05). Conclusion: The levels of serum TNF-&alpha; and IL-4 in CCHF patients were found higher than healthy controls. These cytokines might play an important role in the pathogenesis of CCHF.

Keywords

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Sami Kınıklı Bu kişi benim

Neziha Yılmaz Bu kişi benim

Salih Cesur Bu kişi benim

Ahmet Aydemir Bu kişi benim

Hasan Irmak Bu kişi benim

Cemal Bulut Bu kişi benim

Ali Pekcan Demiröz Bu kişi benim

Gülay Kınıklı Bu kişi benim

Yayımlanma Tarihi

1 Eylül 2011

Gönderilme Tarihi

30 Nisan 2015

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2011 Cilt: 1 Sayı: 03

DOI

https://doi.org/10.5799/ahinjs.02.2011.03.0030

IZ

https://izlik.org/JA27EA56JK

Kaynak Göster

RIS / Bibtex
APA
Kınıklı, S., Yılmaz, N., Cesur, S., Aydemir, A., Irmak, H., Bulut, C., Demiröz, A. P., & Kınıklı, G. (2011). Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases, 1(03). https://doi.org/10.5799/ahinjs.02.2011.03.0030
AMA
1.Kınıklı S, Yılmaz N, Cesur S, vd. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases. 2011;1(03). doi:10.5799/ahinjs.02.2011.03.0030
Chicago
Kınıklı, Sami, Neziha Yılmaz, Salih Cesur, vd. 2011. “Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever”. Journal of Microbiology and Infectious Diseases 1 (03). https://doi.org/10.5799/ahinjs.02.2011.03.0030.
EndNote
Kınıklı S, Yılmaz N, Cesur S, Aydemir A, Irmak H, Bulut C, Demiröz AP, Kınıklı G (01 Eylül 2011) Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases 1 03
IEEE
[1]S. Kınıklı vd., “Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever”, Journal of Microbiology and Infectious Diseases, c. 1, sy 03, Eyl. 2011, doi: 10.5799/ahinjs.02.2011.03.0030.
ISNAD
Kınıklı, Sami - Yılmaz, Neziha - Cesur, Salih - Aydemir, Ahmet - Irmak, Hasan - Bulut, Cemal - Demiröz, Ali Pekcan - Kınıklı, Gülay. “Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever”. Journal of Microbiology and Infectious Diseases 1/03 (01 Eylül 2011). https://doi.org/10.5799/ahinjs.02.2011.03.0030.
JAMA
1.Kınıklı S, Yılmaz N, Cesur S, Aydemir A, Irmak H, Bulut C, Demiröz AP, Kınıklı G. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases. 2011;1. doi:10.5799/ahinjs.02.2011.03.0030.
MLA
Kınıklı, Sami, vd. “Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever”. Journal of Microbiology and Infectious Diseases, c. 1, sy 03, Eylül 2011, doi:10.5799/ahinjs.02.2011.03.0030.
Vancouver
1.Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiröz, Gülay Kınıklı. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases. 01 Eylül 2011;1(03). doi:10.5799/ahinjs.02.2011.03.0030

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