Case Report
Treatment of Mucormycosis with Liposomal Amphotericin B, Posaconazole and Deferasirox: A Case Report
Abstract
In this paper, we present a 69 years old diabetic patient with mucormycosis who was succesfully treated with liposomal
amphotericin B (LAMB), posaconazole and deferasirox despite having no adequate surgery. There was no relapse on
6 month post-treatment follow-up. We conclude that combination of antifungal antibiotics with deferasirox may be
successful in the salvage therapy of mucormycosis especially in diabetic patients. J Microbiol Infect Dis 2016;6(1): 32-35
Keywords
References
- 1. Zeka AN, Taşbakan M, Pullukçu H, et al. Evaluation of zygomycosis cases by pooled analysis method reported from Turkey. Mikrobiyol Bul 2013;47:708-716.
- 2. Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005; 41:634-653.
- 3. Aslan M, Öz Y, Akay MO, Akşit F. Evaluation of febrile neutropenia in hematologic malignancy patients. Mediterr J Infect Microb Antimicrob 2014; 3:20.
- 4. Özden M, Denk A, Demirdağ K, Elkıran T. Investigation of Febrile Neutropenic Cases and Risk Factors. Mediterr J Infect Microb Antimicrob 2014;2:3.
- 5. Cornely OA, Arikan-Akdagli S, Dannaoui E, et al. ESCMID and ECMM Joint Clinical Guidelines for the Diagnosis and Management of Mucormycosis 2013. Clin Microbiol Infec 2014; 20 Suppl. 3:5-26.
- 6. Ibrahim AS, Gebermariam T, Fu Y, et al. The iron chelator deferasirox protects mice from mucormycosis through iron starvation. J Clin Invest 2007;117: 2649-2657.
- 7. Spellberg B, Ibrahim AS, Chin-Hong PV, et al. The Deferasirox–AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial. J Antimicrob Chemother 2012;67:715-722.
- 8. Frater JL, Hall GS, Procop GW. Histologic features of zygomycosis: emphasis on perineural invasion and fungal morphology. Arch Pathol Lab Med 2001; 125: 375-378.
- 9. Rüping MJ, Heinz WJ, Kindo AJ, et al. Forty-one recent cases of invasive zygomycosis from a global clinical registry. J Antimicrob Chemother 2010; 65:296-302.
Year 2016,
Volume: 6 Issue: 1, 32 - 35, 01.03.2016
Abstract
References
- 1. Zeka AN, Taşbakan M, Pullukçu H, et al. Evaluation of zygomycosis cases by pooled analysis method reported from Turkey. Mikrobiyol Bul 2013;47:708-716.
- 2. Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005; 41:634-653.
- 3. Aslan M, Öz Y, Akay MO, Akşit F. Evaluation of febrile neutropenia in hematologic malignancy patients. Mediterr J Infect Microb Antimicrob 2014; 3:20.
- 4. Özden M, Denk A, Demirdağ K, Elkıran T. Investigation of Febrile Neutropenic Cases and Risk Factors. Mediterr J Infect Microb Antimicrob 2014;2:3.
- 5. Cornely OA, Arikan-Akdagli S, Dannaoui E, et al. ESCMID and ECMM Joint Clinical Guidelines for the Diagnosis and Management of Mucormycosis 2013. Clin Microbiol Infec 2014; 20 Suppl. 3:5-26.
- 6. Ibrahim AS, Gebermariam T, Fu Y, et al. The iron chelator deferasirox protects mice from mucormycosis through iron starvation. J Clin Invest 2007;117: 2649-2657.
- 7. Spellberg B, Ibrahim AS, Chin-Hong PV, et al. The Deferasirox–AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial. J Antimicrob Chemother 2012;67:715-722.
- 8. Frater JL, Hall GS, Procop GW. Histologic features of zygomycosis: emphasis on perineural invasion and fungal morphology. Arch Pathol Lab Med 2001; 125: 375-378.
- 9. Rüping MJ, Heinz WJ, Kindo AJ, et al. Forty-one recent cases of invasive zygomycosis from a global clinical registry. J Antimicrob Chemother 2010; 65:296-302.
There are 9 citations in total.
Details
| Subjects | Health Care Administration |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | March 1, 2016 |
| Published in Issue | Year 2016 Volume: 6 Issue: 1 |