An Extensive Therapeutical Drug Monitoring Repository for Localized Population Pharmacokinetics Research

Abstract

Aim: The study's long-term goals, such as determining supratherapeutic ranges according to age distributions specific to the country, adjusting dosages for additional drugs used by patients in different disease groups, and providing the opportunity for etiological studies in the light of diagnosis and drug metabolism perspective, are of great importance in defining the study. Method: Population pharmacokinetics is a method expressed to evaluate processes such as absorption, distribution, metabolism, and elimination of a drug from an individual's blood-plasma concentration. In drug pharmacokinetic experiments, generating data without considering any pharmacokinetic differences among patients prevents the measurement or observation of variability among individuals in the population as a simple approach. The dose-concentration relationship is crucial for individualized dose adjustment. Additionally, the impact of other drugs used by the individual on metabolite levels and the metabolic interactions between drugs play a critical role in the development of personalized treatments. Population approaches provide a foundation that benefits the observation of these effects. The variability in drug metabolism among individuals forms one of the fundamental building blocks of personalized treatment approaches, specifically through Therapeutic Drug Monitoring (TDM), which plays an important role in determining the therapeutic range of drugs. Materials: In this study, drug metabolism findings of patients served at NP Istanbul Brain Hospital between 2010 and 2022 were examined within the repository created along with other patient-specific parameters. Results and Conclusion: The analysis results have been followed up longitudinally, partially demographically, and retrospectively. Thanks to the repository of NP Istanbul Brain Hospital, population pharmacokinetic analyses aimed in this study are being conducted for the first time globally and nationally in terms of scope. The repository has been studied with TDM for individualized treatment methods, and within this project, it is anticipated to perform phenotyping with the population pharmacokinetic approach.

Keywords

• Pharmacokinetics
• Population Pharmacokinetics
• Psychiatric Drugs
• Statistical Analysis
• Therapeutic Drug Monitoring

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