COVID-19 vaccination rate in patients admitted to the Immunology and Allergy Outpatient Clinic

Year 2024, , 42 - 46, 11.03.2024

Merve Erkoç , Selver Seda Mersin

https://doi.org/10.36516/jocass.1429524

Abstract

Aim
Misinformation, lack of awareness, and beliefs about vaccines can cause hesitations about vaccines and affect the rate of vaccination. We aimed to reveal the vaccination rates against coronavirus disease-19 (COVID-19) (vaccine types and dose), and the reasons for not being vaccinated in patients admitted to the immunology and allergy outpatient clinic. In addition, we aimed to find out whether allergic reactions were observed in vaccinated patients.
Methods
The history of COVID-19 and vaccination of patients admitted to the Immunology and Allergy Outpatient Clinic between December 2021 and February 2022 were evaluated retrospectively.
Results
In our study, which included 451 patients, the median age of the patients was 35 (range 18-82), and 61.2% were women. 16.9% of the patients admitted to the immunology and allergy outpatient clinic were never vaccinated, while the rate of those who did not receive two doses of vaccine was 26.6%. The top three reasons for not being vaccinated were fear of allergies, fear of adverse effects, and distrust of the vaccine, respectively. Unvaccinated patients were younger, which is statistically significant. Vaccination rate was found to be lower in drug allergy and immunodeficiencies compared to other disease groups.
Conclusion
Understanding the causes of vaccine hesitations and increasing the vaccination rate by organizing public health campaigns is an important point in the control of the pandemic. Despite being rare, allergic reactions can be observed with COVID-19 vaccines. Therefore, immunologists and allergists play an important role in the COVID-19 vaccine program.

Keywords

Coronavirus disease-19, vaccination, hesitancy, allergic reaction

Ethical Statement

The study protocol was approved by the local Ethics Committe of Gaziantep University, Gaziantep Turkey (No: 2022/126).

Supporting Institution

None

Thanks

None

References

• 1. Turner PJ, Ansotegui IJ, Campbell DE, et al. COVID-19 vaccine-associated anaphylaxis: A statement of the World Allergy Organization Anaphylaxis Committee. World Allergy Organ J 2021; 14: 100517. 2021/02/10. DOI: 10.1016/j.waojou.2021.100517.
• 2. Kaplan B, Farzan S, Coscia G, et al. Allergic reactions to coronavirus disease 2019 vaccines and addressing vaccine hesitancy: Northwell Health experience. Ann Allergy Asthma Immunol 2022; 128: 161-168 e161. 2021/10/27. DOI: 10.1016/j.anai.2021.10.019.
• 3. Erdeljic Turk V. Anaphylaxis associated with the mRNA COVID-19 vaccines: Approach to allergy investigation. Clin Immunol 2021; 227: 108748. 20210428. DOI: 10.1016/j.clim.2021.108748.
• 4. Barbaud A, Garvey LH, Arcolaci A, et al. Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper. Allergy 2022 2022/02/04. DOI: 10.1111/all.15241.
• 5. Mewhirter J, Sagir M and Sanders R. Towards a predictive model of COVID-19 vaccine hesitancy among American adults. Vaccine 2022; 40: 1783-1789. 2022/02/16. DOI: 10.1016/j.vaccine.2022.02.011.
• 6. Storey D. COVID-19 Vaccine Hesitancy. Glob Health Sci Pract 2022; 10 20220301. DOI: 10.9745/GHSP-D-22-00043.
• 7. Ikiisik H, Akif Sezerol M, Tasci Y, et al. COVID-19 vaccine hesitancy: A community-based research in Turkey. Int J Clin Pract 2021; 75: e14336. 20210526. DOI: 10.1111/ijcp.14336.
• 8. Salali GD and Uysal MS. COVID-19 vaccine hesitancy is associated with beliefs on the origin of the novel coronavirus in the UK and Turkey. Psychol Med 2020: 1-3. 20201019. DOI: 10.1017/S0033291720004067.
• 9. Koh SWC, Tan HM, Lee WH, et al. COVID-19 Vaccine Booster Hesitancy among Healthcare Workers: A Retrospective Observational Study in Singapore. Vaccines (Basel) 2022; 10 20220317. DOI: 10.3390/vaccines10030464.
• 10. Mekonnen BD and Mengistu BA. COVID-19 vaccine acceptance and its associated factors in Ethiopia: A systematic review and meta-analysis. Clin Epidemiol Glob Health 2022; 14: 101001. 20220307. DOI: 10.1016/j.cegh.2022.101001.
• 11. Patwary MM, Alam MA, Bardhan M, et al. COVID-19 Vaccine Acceptance among Low- and Lower-Middle-Income Countries: A Rapid Systematic Review and Meta-Analysis. Vaccines (Basel) 2022; 10 20220311. DOI: 10.3390/vaccines10030427.
• 12. Ionescu TC, Fetecau BI, Giurgiuca A, et al. Acceptance and Factors Influencing Acceptance of COVID-19 Vaccine in a Romanian Population. J Pers Med 2022; 12 20220313. DOI: 10.3390/jpm12030452.
• 13. Sypsa V, Roussos S, Engeli V, et al. Trends in COVID-19 Vaccination Intent, Determinants and Reasons for Vaccine Hesitancy: Results from Repeated Cross-Sectional Surveys in the Adult General Population of Greece during November 2020-June 2021. Vaccines (Basel) 2022; 10 20220318. DOI: 10.3390/vaccines10030470.
• 14. Moscardino U, Musso P, Inguglia C, et al. Sociodemographic and psychological correlates of COVID-19 vaccine hesitancy and resistance in the young adult population in Italy. Vaccine 2022 2022/03/21. DOI: 10.1016/j.vaccine.2022.03.018.
• 15. Coulaud PJ, Ablona A, Bolduc N, et al. COVID-19 vaccine intention among young adults: Comparative results from a cross-sectional study in Canada and France. Vaccine 2022 20220303. DOI: 10.1016/j.vaccine.2022.02.085.
• 16. Ameratunga R, Longhurst H, Steele R, et al. Common Variable Immunodeficiency Disorders, T-Cell Responses to SARS-CoV-2 Vaccines, and the Risk of Chronic COVID-19. J Allergy Clin Immunol Pract 2021; 9: 3575-3583. 2021/06/29. DOI: 10.1016/j.jaip.2021.06.019.
• 17. Zarebska-Michaluk D, Rzymski P, Moniuszko-Malinowska A, et al. Does Hospitalization Change the Perception of COVID-19 Vaccines among Unvaccinated Patients? Vaccines (Basel) 2022; 10 20220319. DOI: 10.3390/vaccines10030476.
• 18. Kharbanda EO and Vazquez-Benitez G. COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy. JAMA 2022 2022/03/25. DOI: 10.1001/jama.2022.2459.
• 19. Pitlick MM, Joshi AY, Gonzalez-Estrada A, et al. Delayed systemic urticarial reactions following mRNA COVID-19 vaccination. Allergy Asthma Proc 2022; 43: 40-43. DOI: 10.2500/aap.2022.43.210101.
• 20. Castells M, Demoly P and Tanno LK. [Anaphylaxis and COVID-19 vaccines]. Rev Fr Allergol (2009) 2021; 61: 8S30-38S35. 20211230. DOI: 10.1016/S1877-0320(21)00439-5.
• 21. Armstrong L and Maguire N. A Case Report of Prolonged Anaphylaxis after COVID-19 Vaccine. Clin Pract Cases Emerg Med 2022; 6: 21-24. DOI: 10.5811/cpcem.2021.9.53690.
• 22. Laisuan W, Wongsa C, Chiewchalermsri C, et al. CoronaVac COVID-19 Vaccine-Induced Anaphylaxis: Clinical Characteristics and Revaccination Outcomes. J Asthma Allergy 2021; 14: 1209-1215. 20211007. DOI: 10.2147/JAA.S333098.
• 23. Cahill JA and Kan M. Successful administration of second dose of BNT162b2 COVID-19 vaccine in two patients with potential anaphylaxis to first dose. Allergy 2022; 77: 337-338. DOI: 10.1111/all.14996.