Role of Tacrolimus in Preventing Intra-Abdominal Adhesions

Abstract

Aim: The study aimed to identify whether tacrolimus has preventive effects on intraperitoneal adhesions. Methods: Thirty-four 8–10-week-old male Wistar Albino rats were used. They were randomized into 3 groups; control group, abdominal lavage group, and systemic administration group. The features of abdominal adhesions were evaluated macroscopically, and the degree of adhesion within rats was graded by using Nair and Knightly adhesion grading scales. Results: Adhesion grades were significantly lower in tacrolimus administered groups. However, route of tacrolimus administration did not affect the reduction of adhesion formation. Conclusion: Tacrolimus has been observed to potentially mitigate the incidence of intraperitoneal adhesion formation without significantly compromising wound healing processes. Key words: Tacrolimus; intraperitoneal adhesion; wound healing; rats.

Keywords

• Tacrolimus
• intraperitonel adhesion
• wound healing
• rats

Ethical Statement

The experimental procedures were carried out in accordance with the guidelines established for the use of vertebrates in experimental settings. This study was approved by Ankara University, Local Ethics Committee for Animal Experiments (protocol number: 2009-38-182, date: 2009/03/04).

Takrolimusun Karın İçi Yapışıklıkların Önlenmesindeki Rolü

Abstract

Özet Amaç: Bu çalışma, takrolimusun intraperitoneal yapışıklıklara karşı önleyici etkilerinin olup olmadığını belirlemeyi amaçlamıştır. Metot: Bu çalışmada 8-10 haftalık 34 erkek Wistar Albino sıçan kullanılmıştır. Sıçanlar 3 gruba randomize edilmiştir; kontrol grubu, karın yıkama grubu ve sistemik uygulama grubu. Karın yapışıklıklarının özellikleri makroskopik olarak değerlendirilmiş ve sıçanlardaki yapışıklık derecesi Nair ve Knightly yapışıklık derecelendirme ölçekleri kullanılarak derecelendirilmiştir. Bulgular: Yapışıklık dereceleri takrolimus uygulanan gruplarda anlamlı derecede daha düşüktü. Bununla birlikte, takrolimus uygulama yolu yapışıklık oluşumunun azalmasını etkilememiştir. Sonuç: Takrolimusun, yara iyileşme süreçlerini önemli ölçüde etkilemeden, karın içi yapışıklık oluşumunu potansiyel olarak azalttığı gözlemlenmiştir. Anahtar kelimeler: Takrolimus; intraperitoneal yapışıklık; yara iyileşmesi; ratlar.

Keywords

• Takrolimus
• intraperitoneal yapışıklık
• yara iyileşmesi
• ratlar

Ethical Statement

Deneysel işlemler, omurgalıların deneysel ortamlarda kullanımı için belirlenen yönergelere uygun olarak gerçekleştirilmiştir. Bu çalışma, Ankara Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu tarafından onaylanmıştır (protokol numarası: 2009-38-182, tarih: 2009/03/04).

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