Kosta ve Vertebraya Nadir Metastaz Gösteren Papiller Tiroid Karsinomu: Olgu Sunumu

Öz

Papiller tiroid karsinomu, tüm tiroid karsinomlarının yaklaşık %80'ini oluşturan, diferansiye tiroid kanserinin en yaygın patolojik türüdür. Papiller tiroid karsinomunun yavaş ilerleyen bir davranışı vardır, uzak metastazlar nadirdir ve hastalığın agresif davranışını gösterir. Papiller tiroid karsinomunun kemik metastazı %1-7 civarında çok nadirdir. Bu olgu sunumunda, 57 yaşındaki erkek hastanın kosta ve vertebrasında görülen olağandışı papiller tiroid karsinomu metastazlarının tanı ve tedavisi sunulmuştur. Hastanın 26 yıl önce subtotal tiroidektomi öyküsü vardı. Sunulan vaka, papiller tiroid karsinomu metastazlarının, primer tümörün tedavisinden uzun süre sonra sıra dışı bölgelerde gözlemlenebileceğini göstermektedir.

Anahtar Kelimeler

• Papiller Tiroid Karsinomu
• metastaz
• kosta
• vertebra
• nadir

Papillary Thyroid Carcinoma with Rare Metastases to Costa and Vertebrae: Case Report

Abstract

Papillary thyroid carcinoma (PTC) is the most common pathological type of differentiated thyroid cancer, which accounts for about 80% of all thyroid carcinomas. PTC has a slow progressing behavior, distant metastases are rare, indicating aggressive behavior of the disease. Bone metastasis of PTC is very rare at around 1-7%. In this case report, the diagnosis and treatment of unusual PTC metastases observed in costa and vertebrae of a 57-year-old male patient is presented. The patient had a history of subtotal thyroidectomy 26 years ago. The presented case indicates that PTC metastases can be observed in unusual areas long after the treatment of the primary tumor.

Keywords

• Papillary Thyroid Carcinoma
• metastasis
• costa
• vertebrae
• rare

References

1. Zhu X, Yao J, Tian W. Microarray technology to investigate genes associated with papillary thyroid carcinoma. Mol Med Rep 2015;11:3729-33.
2. Schneider DF, Chen H. New developments in the diagnosis and treatment of thyroid cancer. CA Cancer J Clin 2013;63:374-94.
3. Haraldsdottir S, Shah MH. New era for treatment in differentiated thyroid cancer. Lancet 2014;384:286-8.
4. Paricharttanakul NM, Saharat K, Chokchaichamnankit D, et al. Unveiling a novel biomarker panel for diagnosis and classification of well-differentiated thyroid carcinomas. Oncol Rep 2016;35:2286-96.
5. Song HJ, Xue YL, Qiu ZL, et al. Uncommon metastases from differentiated thyroid carcinoma. Hell J Nucl Med 2012;15:233-40.
6. Sugitani I, Fujimoto Y, Yamamoto N. Papillary thyroid carcinoma with distant metastases: survival predictors and the importance of local control. Surgery 2008;143:35-42.
7. Chrisoulidou A, Boudina M, Tzemailas A, et al. Histological subtype is the most important determinant of survival in metastatic papillary thyroid cancer, Thyroid Res, 2011;4:12.
8. Rahman MM AM, Karim MA, Arafat MS, et al. Frequency of malignancy in multinodular goitre. Bangladesh J Otorhinolaryngol 2015;20:75-9.

9. LiVolsi VA. Papillary thyroid carcinoma: An update. Mod Pathol; 24 Suppl 2011;2:S1-9.
10. Shrestha SK, Joshi MR, Sharma SK. Total thyroidectomy: the treatment of choice in differentiated thyroid carcinoma. Kathmandu Univ Med J (KUMJ) 2005; 3:3538.
11. Lam AK, Lo CY, Lam KS. Papillary carcinoma of thyroid: a 30-yr clinicopathological review of the histological variants. EndocrPathol 2005;16:323-30.
12. Shaha R, Shah JP, Loree TR. Differentiated thyroid cancer presenting initially with distant metastasis. Am J Surg 1997;174:474-6.
13. Kuschayeva YS, Kuschayev SV, Carroll NM, et al. Spinal metastases due to thyroid carcinoma: an analysis of 202 patients. Thyroid 2014;24:1488-500.
14. Sampson E, Brierley JD, Le LW, et al. Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis. Cancer 2007;110:1451-6.