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Investigation of the Relationship Between Epicardial Fat Tissue Thickness and Hemoglobin A1c Levels

Year 2021, Volume: 4 Issue: 2, 75 - 80, 31.08.2021

Abstract

Objective: There is a linear relationship between Epicardial Adipose tissue (EAT) thickness and cardiovascular diseases and diabetes mellitus (DM). However, the relationship between HbA1c, which is a direct measure of blood sugar regulation in DM, and EAT has not been questioned. In this study, the relationship between EAT and HbA1c was investigated.
Method: A total of 90 patients who were admitted to our cardiology clinic were included in the study consecutively. The EATs of the patients were measured by echocardiography and compared with their HbA1c values.
Result: Body mass index, fasting blood glucose, HbA1c and body weight are positively correlated with EAT (p<0.05)
Conclusion: In this study, it was shown that there is a direct relationship between HbA1c and EAT, and it was emphasized that EAT can guide the follow-up of preclinical diabetes and glucose control.

References

  • 1. Bertaso AG, Bertol D, Duncan BB, Foppa M. Epicardial fat: definition, measurements and systematic review of main outcomes. Arq Bras Cardiol 2013; 101: e18-e28 [PMID: 23917514 DOI: 10.5935/abc.20130138].
  • 2. Katsiki N, Mikhailidis DP, Wierzbicki AS. Epicardial fat and vascular risk: a narrative review. Curr Opin Cardiol 2013; 28: 458-463 [PMID: 23591557 DOI: 10.1097/HCO.0b013e3283605fba]
  • 3. Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK, Wong DT. Epicardial adipose tissue: far more than a fat depot. Cardiovasc Diagn Ther 2014; 4: 416-429 [PMID: 25610800 DOI: 10.3978/j.issn.2223-3652.2014.11.05].
  • 4. IDF Diabetes Atlas. IDF diabetes atlas 8th edition [Internet]. 2017 [cited 2019 May 13]. Available from: https://www.diabetesatlas.org/ 5. Donaghue KC, Marcovecchio ML, Wadwa RP, Chew EY, Wong TY, Calliari LE, Zabeen B, Salem MA, Craig ME. ISPAD Clinical Practice Consensus Guidelines 2018: Microvascular and macrovascular complications in children and adolescents. Pediatr Diabetes 2018; 19 Suppl 27: 262-274 [PMID: 30079595 DOI: 10.1111/pedi.12742]
  • 6. Papatheodorou K, Papanas N, Banach M, Papazoglou D, Edmonds M. Complications of Diabetes 2016. J Diabetes Res 2016; 2016: 6989453 [PMID: 27822482 DOI: 10.1155/2016/6989453] 7. Papatheodorou K, Banach M, Bekiari E, Rizzo M, Edmonds M. Complications of Diabetes 2017. J Diabetes Res 2018; 2018: 3086167 [PMID: 29713648 DOI: 10.1155/2018/3086167].
  • 8. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998; 352: 837–53.
  • 9. Khaw KT. Elevated HbA1c level: A risk factor for cardiovascular disease mortality in patients with chronic heart failure? Nat Clin Pract Endocrinol Metab. 2009; 5: 130–1.
  • 10. Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, Di Mario U, Leonetti F. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab. 2003 Nov;88(11):5163-8. [DOI: 10.1210/jc.2003-030698. PMID: 14602744]
  • 11. Iacobellis G, Gao YJ, Sharma AM. Do cardiac and perivascular adipose tissue play a role in atherosclerosis? Curr Diab Rep. 2008 Feb;8(1):20-4 [DOI: 10.1007/s11892-008-0005-2. PMID: 18366994].
  • 12. ACE/ADA Task Force on Inpatient Diabetes. American College of Endocrinology and American Diabetes Association Consensus statement on inpatient diabetes and glycemic control. Diabetes Care. 2006 Aug;29(8):1955-62. 4 [DOI: 10.2337/dc06-9913. PMID: 16873812].
  • 13. AsoĞlu R, Özdemİr M, AladaĞ N, AsoĞlu E. Evaluation of Epicardial Adipose Tissue by Echocardiography and Its Correlation with Aortic Velocity Propagation and Carotid Intima-Media Thickness in Patients of Type 2 Diabetes Mellitus. An Acad Bras Cienc. 2020 Nov 16;92(4):e20191457. [DOI: 10.1590/0001-3765202020191457. PMID: 33206787].
  • 14. Jeong JW, Jeong MH, Yun KH, Oh SK, Park EM, Kim YK, Rhee SJ, Lee EM, Lee J, Yoo NJ, Kim NH, Park JC. Echocardiographic epicardial fat thickness and coronary artery disease. Circ J. 2007 Apr;71(4):536-9. [DOI: 10.1253/circj.71.536. PMID: 17384455].
  • 15. Iacobellis G, Barbaro G, Gerstein HC. Relationship of epicardial fat thickness and fasting glucose. Int J Cardiol. 2008 Aug 29;128(3):424-6. doi: 10.1016/j.ijcard.2007.12.072. Epub 2008 Mar 28. PMID: 18375002].
  • 16. Sironi AM, Pingitore A, Ghione S, De Marchi D, Scattini B, Positano V, Muscelli E, Ciociaro D, Lombardi M, Ferrannini E, Gastaldelli A. Early hypertension is associated with reduced regional cardiac function, insulin resistance, epicardial, and visceral fat. Hypertension. 2008 Feb;51(2):282-8. [DOI: 10.1161/HYPERTENSIONAHA.107.098640. Epub 2008 Jan 2. PMID: 18172058].
  • 17. Ding L, Xu Y, Liu S, Bi Y, Xu Y. Hemoglobin A1c and diagnosis of diabetes. J Diabetes. 2018 May;10(5):365-372. [DOI: 10.1111/1753-0407.12640. Epub 2018 Feb 9. PMID: 29292842].
  • 18. Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, Coresh J, Brancati FL. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010 Mar 4;362(9):800-11. [DOI: 10.1056/NEJMoa0908359. PMID: 20200384; PMCID: PMC2872990].
  • 19. Li Y, Liu B, Li Y, Jing X, Deng S, Yan Y, She Q. Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol. 2019 Jan 10;18(1):3. doi: 10.1186/s12933-019-0807-3. [PMID: 30630489; PMCID: PMC6327515].
  • 20. Christensen RH, von Scholten BJ, Hansen CS, Jensen MT, Vilsbøll T, Rossing P, Jørgensen PG. Epicardial adipose tissue predicts incident cardiovascular disease and mortality in patients with type 2 diabetes. Cardiovasc Diabetol. 2019 Aug 30;18(1):114. [DOI: 10.1186/s12933-019-0917-y. PMID: 31470858; PMCID: PMC6716926].
  • 21. Iacobellis G, Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab. 2005 Nov;90(11):6300-2 [DOI: 10.1210/jc.2005-1087. Epub 2005 Aug 9. PMID: 16091479].
  • 22. Abel ED, O'Shea KM, Ramasamy R. Insulin resistance: metabolic mechanisms and consequences in the heart. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2068-76. [DOI: 10.1161/ATVBAHA.111.241984. PMID: 22895668; PMCID: PMC3646067].
  • 23. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999 Oct 7;341(15):1097-105[DOI: 10.1056/NEJM199910073411501. PMID: 10511607].
  • 24. Abel ED, O'Shea KM, Ramasamy R. Insulin resistance: metabolic mechanisms and consequences in the heart. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2068-76. [DOI: 10.1161/ATVBAHA.111.241984. PMID: 22895668; PMCID: PMC3646067].

Epikardiyal Yağ Dokusu Kalinliği ile Hemoglobin A1c Değerleri Arasindaki İlişkinin İncelenmesi

Year 2021, Volume: 4 Issue: 2, 75 - 80, 31.08.2021

Abstract

Amaç: Epikardiyal Yağ dokusu (EYD) kalınlığı ile kardiyovaküler hastalılar ve diyabetes mellitus (DM) arasında doğrusal bir ilişki vardır. Fakat DM'de kan şekeri regülâsyonun doğrudan bir ölçüsü olan HbA1c ile EYD arasındaki ilişki sorgulanmamıştır. Bu çalışmada EYD ile HbA1c arasındaki ilişki sorgulandı.
Metot: Kardiyoloji kliniğimize başvuran toplam 90 hasta ardışık olarak çalışmaya dâhil edildi. Hastaların EYD'leri ekokardiyografi ile ölçüldü ve onların HbA1c değerleri ile karşılaştırıldı.
Bulgular: Vücut kitle indeksi, açlık kan şekeri, HbA1c, vücut ağırlığı ile EYD arasında doğrusal bir ilişki bulundu (p<0.05).
Sonuç: Bu çalışmada, HbA1c ve EYD arasında doğrudan bir ilişki olduğu gösterildi ve EYD'nin preklinik diyabetin takibinde ve glikoz kontrolünde rehberlik edebileceği vurgulandı.

References

  • 1. Bertaso AG, Bertol D, Duncan BB, Foppa M. Epicardial fat: definition, measurements and systematic review of main outcomes. Arq Bras Cardiol 2013; 101: e18-e28 [PMID: 23917514 DOI: 10.5935/abc.20130138].
  • 2. Katsiki N, Mikhailidis DP, Wierzbicki AS. Epicardial fat and vascular risk: a narrative review. Curr Opin Cardiol 2013; 28: 458-463 [PMID: 23591557 DOI: 10.1097/HCO.0b013e3283605fba]
  • 3. Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK, Wong DT. Epicardial adipose tissue: far more than a fat depot. Cardiovasc Diagn Ther 2014; 4: 416-429 [PMID: 25610800 DOI: 10.3978/j.issn.2223-3652.2014.11.05].
  • 4. IDF Diabetes Atlas. IDF diabetes atlas 8th edition [Internet]. 2017 [cited 2019 May 13]. Available from: https://www.diabetesatlas.org/ 5. Donaghue KC, Marcovecchio ML, Wadwa RP, Chew EY, Wong TY, Calliari LE, Zabeen B, Salem MA, Craig ME. ISPAD Clinical Practice Consensus Guidelines 2018: Microvascular and macrovascular complications in children and adolescents. Pediatr Diabetes 2018; 19 Suppl 27: 262-274 [PMID: 30079595 DOI: 10.1111/pedi.12742]
  • 6. Papatheodorou K, Papanas N, Banach M, Papazoglou D, Edmonds M. Complications of Diabetes 2016. J Diabetes Res 2016; 2016: 6989453 [PMID: 27822482 DOI: 10.1155/2016/6989453] 7. Papatheodorou K, Banach M, Bekiari E, Rizzo M, Edmonds M. Complications of Diabetes 2017. J Diabetes Res 2018; 2018: 3086167 [PMID: 29713648 DOI: 10.1155/2018/3086167].
  • 8. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998; 352: 837–53.
  • 9. Khaw KT. Elevated HbA1c level: A risk factor for cardiovascular disease mortality in patients with chronic heart failure? Nat Clin Pract Endocrinol Metab. 2009; 5: 130–1.
  • 10. Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, Di Mario U, Leonetti F. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab. 2003 Nov;88(11):5163-8. [DOI: 10.1210/jc.2003-030698. PMID: 14602744]
  • 11. Iacobellis G, Gao YJ, Sharma AM. Do cardiac and perivascular adipose tissue play a role in atherosclerosis? Curr Diab Rep. 2008 Feb;8(1):20-4 [DOI: 10.1007/s11892-008-0005-2. PMID: 18366994].
  • 12. ACE/ADA Task Force on Inpatient Diabetes. American College of Endocrinology and American Diabetes Association Consensus statement on inpatient diabetes and glycemic control. Diabetes Care. 2006 Aug;29(8):1955-62. 4 [DOI: 10.2337/dc06-9913. PMID: 16873812].
  • 13. AsoĞlu R, Özdemİr M, AladaĞ N, AsoĞlu E. Evaluation of Epicardial Adipose Tissue by Echocardiography and Its Correlation with Aortic Velocity Propagation and Carotid Intima-Media Thickness in Patients of Type 2 Diabetes Mellitus. An Acad Bras Cienc. 2020 Nov 16;92(4):e20191457. [DOI: 10.1590/0001-3765202020191457. PMID: 33206787].
  • 14. Jeong JW, Jeong MH, Yun KH, Oh SK, Park EM, Kim YK, Rhee SJ, Lee EM, Lee J, Yoo NJ, Kim NH, Park JC. Echocardiographic epicardial fat thickness and coronary artery disease. Circ J. 2007 Apr;71(4):536-9. [DOI: 10.1253/circj.71.536. PMID: 17384455].
  • 15. Iacobellis G, Barbaro G, Gerstein HC. Relationship of epicardial fat thickness and fasting glucose. Int J Cardiol. 2008 Aug 29;128(3):424-6. doi: 10.1016/j.ijcard.2007.12.072. Epub 2008 Mar 28. PMID: 18375002].
  • 16. Sironi AM, Pingitore A, Ghione S, De Marchi D, Scattini B, Positano V, Muscelli E, Ciociaro D, Lombardi M, Ferrannini E, Gastaldelli A. Early hypertension is associated with reduced regional cardiac function, insulin resistance, epicardial, and visceral fat. Hypertension. 2008 Feb;51(2):282-8. [DOI: 10.1161/HYPERTENSIONAHA.107.098640. Epub 2008 Jan 2. PMID: 18172058].
  • 17. Ding L, Xu Y, Liu S, Bi Y, Xu Y. Hemoglobin A1c and diagnosis of diabetes. J Diabetes. 2018 May;10(5):365-372. [DOI: 10.1111/1753-0407.12640. Epub 2018 Feb 9. PMID: 29292842].
  • 18. Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, Coresh J, Brancati FL. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010 Mar 4;362(9):800-11. [DOI: 10.1056/NEJMoa0908359. PMID: 20200384; PMCID: PMC2872990].
  • 19. Li Y, Liu B, Li Y, Jing X, Deng S, Yan Y, She Q. Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol. 2019 Jan 10;18(1):3. doi: 10.1186/s12933-019-0807-3. [PMID: 30630489; PMCID: PMC6327515].
  • 20. Christensen RH, von Scholten BJ, Hansen CS, Jensen MT, Vilsbøll T, Rossing P, Jørgensen PG. Epicardial adipose tissue predicts incident cardiovascular disease and mortality in patients with type 2 diabetes. Cardiovasc Diabetol. 2019 Aug 30;18(1):114. [DOI: 10.1186/s12933-019-0917-y. PMID: 31470858; PMCID: PMC6716926].
  • 21. Iacobellis G, Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab. 2005 Nov;90(11):6300-2 [DOI: 10.1210/jc.2005-1087. Epub 2005 Aug 9. PMID: 16091479].
  • 22. Abel ED, O'Shea KM, Ramasamy R. Insulin resistance: metabolic mechanisms and consequences in the heart. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2068-76. [DOI: 10.1161/ATVBAHA.111.241984. PMID: 22895668; PMCID: PMC3646067].
  • 23. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999 Oct 7;341(15):1097-105[DOI: 10.1056/NEJM199910073411501. PMID: 10511607].
  • 24. Abel ED, O'Shea KM, Ramasamy R. Insulin resistance: metabolic mechanisms and consequences in the heart. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2068-76. [DOI: 10.1161/ATVBAHA.111.241984. PMID: 22895668; PMCID: PMC3646067].
There are 22 citations in total.

Details

Primary Language English
Subjects Cardiovascular Surgery
Journal Section Articles
Authors

Fatih Aydın 0000-0002-1017-1917

Özge Turgay Yıldırım 0000-0002-6731-4958

Publication Date August 31, 2021
Acceptance Date July 24, 2021
Published in Issue Year 2021 Volume: 4 Issue: 2

Cite

APA Aydın, F., & Turgay Yıldırım, Ö. (2021). Investigation of the Relationship Between Epicardial Fat Tissue Thickness and Hemoglobin A1c Levels. Journal of Cukurova Anesthesia and Surgical Sciences, 4(2), 75-80.

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