Lokal İleri Meme Kanseri Hastalarında Neoadjuvan Tedavi Sonrası Patolojik Tam Yanıtı Tahmin Etmede Radyolojik Yöntemlerin Etkinliği

Year 2023, Volume: 6 Issue: 2, 235 - 240, 31.08.2023

Serkan Erkan , Hakan Yabanoğlu , Ramazan Gündoğdu , Tevfik Avcı , Eda Çakmak

https://doi.org/10.36516/jocass.1294672

Abstract

Öz
Amaç: Meme kanseri tedavisindeki güncel yenilikler, neoadjuvan tedavinin kullanımının artmasına neden olmuştur. Neoadjuvan tedaviyi takiben patolojik tam yanıt , sağkalımı tahmin etmek için çok önemli bir prognostik faktördür. Bu çalışmanın amacı, lokal ileri meme kanserli hastalarımızda radyolojik yöntemlerin patolojik tam yanıtı öngörmedeki etkinliğini göstermektir.
Materyal ve Metod: Hastanemizde Ocak 2017-Ocak 2022 tarihleri arasında meme kanseri tedavisi gören hastaların tıbbi kayıtları retrospektif olarak incelendi. Çalışmaya, neoadjuvan kemoterapi uygulanan, lokal ileri tek odaklı meme kanserli 18 yaş üstü kadın hastalar dahil edildi. Hastaların demografik bilgileri, menopoz durumu, moleküler alt tipleri, radyolojik sonuçları, hastalık evresi, tedavi ve cerrahi yöntemleri, patoloji sonuçları kaydedildi.
Bulgular: Toplam 4474 hasta meme kanseri tedavisi gördü ve bunların 94'ü bu çalışmanın kriterlerini karşıladı. Hastaların yaş ortalaması 49,9 ± 11,06 idi. Radyolojik yanıt değerlendirmesi için tüm hastalara ultrasonografi, 47 (%50) hastaya FDG-PetCT ve 31 (%33) hastaya manyetik rezonans görüntüleme (MRG) yapıldı. Radyolojik tam yanıt FDG-petCT grubunda (%39.4) en yüksekti. Patolojik tam yanıt oranı %35.1 idi.
Sonuç: FDG-PETCT'nin lokal ileri meme kanserlerinde neoadjuvan kemoterapi sonrası patolojik tam yanıtı öngörmede yüksek duyarlılığı olmasına rağmen, ultrasonografi, FDG-PETCT ve manyetik rezonans görüntülemenin ortak kullanımı, farklı yararları nedeniyle daha avantajlıdır.

Keywords

meme, meme kanseri, neoadjuvan tedavi

Supporting Institution

Başkent Üniversitesi

Project Number

KA22/457

Thanks

Başkent Üniversitesine desteklerinden dolayı teşekkür ederim.

The Effectiveness of Radiological Methods in Predicting Pathological Complete Response After Neoadjuvant Therapy in Locally Advanced Breast Cancer Patients

Abstract

Abstract

Aim: The current innovations in breast cancer treatment have led to an increased utilization of neoadjuvant therapy. Pathological complete response following neoadjuvant therapy is a crucial prognostic factor for predicting survival. The objective of this study is to demonstrate the efficacy of radiological methods in predicting patholojical complete response in our patients with locally advanced breast cancer.
Material and Methods: The medical records of patients who received treatment for breast cancer at our hospital between January 2017 and January 2022 were retrospectively reviewed. The study included female patients over the age of 18 with locally advanced unifocal breast cancer who underwent neoadjuvant chemotherapy. Demographic information, menopausal status, molecular subtypes, radiological results, disease stage, treatment and surgical methods, and pathology results were recorded.
Results: A total of 4474 patients were treated for breast cancer out of which 94 patients met the criteria for this study. The mean age of the patients was 49.9 ± 11.06 years. Ultrasonography was performed on all patients, while FDG-PetCT was performed on 47 (50%) patients and magnetic resonance imaging (MRI) was performed on 31 (33%) patients for radiological response evaluation. The radiological complete response was highest in the FDG-petCT group (39.4%). The rate of pathological complete response was 35.1%.
Conclusion: Although FDG-PETCT has high sensitivity in predicting pathological complete response after neoadjuvant chemotherapy in locally advanced breast cancers, the common use of ultrasonography, FDG-PETCT, and magnetic resonance imaging is more advantageous due to their different benefits.

Keywords

breast, beast cancer, neoadjuvant therapy

Project Number

KA22/457

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