Epilepsi türlerine göre gündüz uyku hali düzeylerinin değerlendirilmesi Özet

Year 2025, Volume: 8 Issue: 1, 51 - 55

Metin Balduz , Halit Fidancı

Abstract

Giriş: Bu çalışma, yetişkin epilepsi hastalarında elektroensefalogram (EEG) bulguları, klinik özellikler ve öznel uyku ölçümleri arasındaki ilişkiyi araştırmayı amaçlamıştır.
Gereç ve Yöntemler: Daha önce epilepsi tanısı almış 105 hasta bu çalışmaya dahil edilmiştir. EEG kayıtları interiktal epileptiform deşarjlar açısından analiz edilmiştir. Katılımcılar jeneralize epilepsi ve fokal epilepsi şeklinde iki gruba ayrılmış, fokal epilepsi hastaları da alt gruplara ayrılmıştır. Uyku kalitesini değerlendirmek için Jenkins Uyku Ölçeği (JSS), gündüz uykululuğunu değerlendirmek için ise Epworth Uykululuk Ölçeği (ESS) kullanılmıştır. Gruplar arasında ikili karşılaştırmalar yapılarak istatistiksel veriler elde edilmiştir.
Bulgular: Bu çalışma EEG bulguları ile cinsiyet arasında anlamlı bir ilişki olduğunu ortaya koymuştur; frontal lob epilepsisinin (FLE) kadınlarda, temporal lob epilepsisinin (TLE) ise erkeklerde daha yaygın olduğu görülmüştür. Tedavi yöntemlerine göre monoterapinin FLE ve TLE hastalarında baskın olduğu tespit edilmiş, ancak gruplar arasında istatistiksel olarak fark bulunmamıştır. EEG anormallikleri en sık temporal ve jeneralize anormallikler şeklinde gözlenmiştir. ESS ve JSS puanlarında epilepsi grupları arasında anlamlı farklar bulunmuş, en yüksek puanlar FLE grubunda gözlemlenmiştir. ESS ve JSS puanları arasında pozitif bir korelasyon bulunmuştur.
Sonuç: Epilepsinin, bir bireyin yaşamının çeşitli yönleri üzerindeki etkisi, özellikle uyku açısından, oldukça önemlidir. Bu çalışma, epilepsisi olan bireyler için klinik uygulamada kapsamlı uyku değerlendirmelerinin yapılmasının önemini vurgulamaktadır.

Keywords

Epilepsi, uyku, Epworth, Jenkins

Evaluation of Daytime Sleepiness Levels According to Types of Epilepsy

Abstract

Aim: This study aimed to investigate the relationship between electroencephalogram (EEG) findings, clinical characteristics, and subjective sleep measures in adult patients with epilepsy.
Material and Methods: 105 patients previously diagnosed with epilepsy were included in this study. EEG recordings analyzed for interictal epileptiform discharges. Participants were divided into two groups: generalized and focal epilepsy, patients with focal epilepsy were also divided into subgroups. The Jenkins Sleep Scale (JSS) and Epworth Sleepiness Scale (ESS) were used to assess sleep quality and daytime sleepiness, respectively. Statistical data were obtained by making pairwise comparisons between groups.
Findings: This study revealed that there is a significant association between EEG findings and gender, with frontal lobe epilepsy (FLE) more prevalent in females and temporal lobe epilepsy (TLE) more common in males. According to treatment modalities, monotherapy was predominantly in patients with FLE and TLE, but statistically there is no difference across the groups. EEG abnormalities varied, with temporal and generalized abnormalities most prevalent. Significant differences were found in ESS and JSS scores across epilepsy groups, with higher scores observed in FLE. A positive correlation was found between ESS and JSS scores.
Results: The impact of epilepsy on various aspects of a person's life, including sleep, is significant. This study underscores the importance of conducting comprehensive sleep assessments in clinical practice for individuals with epilepsy.

Keywords

Epilepsy, sleep, Epworth, Jenkins

References

• 1.Grigg-Damberger MM, Foldvary-Schaefer N. Primary sleep disorders in people with epilepsy: clinical questions and answers. Child Adolesc Psychiatr Clin N Am. 2015;24(1):145-76. https://doi.org/10.1016/j.chc.2014.09.001
• 2.Malow BA. Sleep disorders, epilepsy, and autism. Ment Retard Dev Disabil Res Rev. 2004;10(2):122-5. https://doi.org/10.1002/mrdd.20023
• 3.Bazil CW, Walczak TS. Effects of sleep and sleep stage on epileptic and nonepileptic seizures. Epilepsia. 1997;38(1):56-62. https://doi.org/10.1111/j.1528-1157.1997.tb01077.x
• 4.Touchon J, Baldy-Moulinier M, Billiard M, Besset A, Cadilhac J. Sleep organization and epilepsy. Epilepsy Res Suppl. 1991;2:73-81.
• 5.Foldvary-Schaefer N, Grigg-Damberger M. Sleep and epilepsy: what we know, don't know, and need to know. J Clin Neurophysiol. 2006;23(1):4-20. https://doi.org/10.1097/01.wnp.0000206877.90232.cb
• 6.Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522-30. https://doi.org/10.1111/epi.13670
• 7.Kane N, Acharya J, Benickzy S, Caboclo L, Finnigan S, Kaplan PW, et al. A revised glossary of terms most commonly used by clinical electroencephalographers and updated proposal for the report format of the EEG findings. Revision 2017. Clin Neurophysiol Pract. 2017;2:170-85. https://doi.org/10.1016/j.cnp.2017.07.002
• 8.Kural MA, Duez L, Sejer Hansen V, Larsson PG, Rampp S, Schulz R, et al. Criteria for defining interictal epileptiform discharges in EEG: A clinical validation study. Neurology. 2020;94(20):e2139-e47. https://doi.org/10.1212/WNL.0000000000009439
• 9.Jenkins CD, Stanton BA, Niemcryk SJ, Rose RM. A scale for the estimation of sleep problems in clinical research. J Clin Epidemiol. 1988;41(4):313-21. https://doi.org/10.1016/0895-4356(88)90138-2
• 10.Schubert CR, Cruickshanks KJ, Dalton DS, Klein BE, Klein R, Nondahl DM. Prevalence of sleep problems and quality of life in an older population. Sleep. 2002;25(8):889-93.
• 11.Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540-5. https://doi.org/10.1093/sleep/14.6.540
• 12.Duruöz MT, Ünal Ç, Ulutatar F, Sanal Toprak C, Gündüz OH. The Validity and Reliability of Turkish Version of the Jenkins Sleep Evaluation Scale in Rheumatoid Arthritis. Arch Rheumatol. 2018;33(2):160-7. https://doi.org/10.5606/ArchRheumatol.2018.6376
• 13.Foldvary-Schaefer N, Neme-Mercante S, Andrews N, Bruton M, Wang L, Morrison S, et al. Wake up to sleep: The effects of lacosamide on daytime sleepiness in adults with epilepsy. Epilepsy Behav. 2017;75:176-82. https://doi.org/10.1016/j.yebeh.2017.08.002
• 14.Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475-82. https://doi.org/10.1111/epi.12550
• 15.Kobau R, Gilliam F, Thurman DJ. Prevalence of self-reported epilepsy or seizure disorder and its associations with self-reported depression and anxiety: results from the 2004 HealthStyles Survey. Epilepsia. 2006;47(11):1915-21. https://doi.org/10.1111/j.1528-1167.2006.00612.x
• 16.Vignatelli L, Bisulli F, Giovannini G, Licchetta L, Naldi I, Mostacci B, et al. Prevalence of nocturnal frontal lobe epilepsy in the adult population of Bologna and Modena, Emilia-Romagna region, Italy. Sleep. 2015;38(3):479-85. https://doi.org/10.5665/sleep.4514
• 17.Motamedi M, Yordkhani F, Shirali A, Gheini M. Comparison of the baseline, waking and sleep EEGs after sleep deprivation in patients with sleep seizure. Tehran University Medical Journal. 2011;69(8).
• 18.Kothare SV, Kaleyias J. Sleep and epilepsy in children and adolescents. Sleep Med. 2010;11(7):674-85. https://doi.org/10.1016/j.sleep.2010.01.012
• 19.Byars AW, Byars KC, Johnson CS, DeGrauw TJ, Fastenau PS, Perkins S, et al. The relationship between sleep problems and neuropsychological functioning in children with first recognized seizures. Epilepsy Behav. 2008;13(4):607-13. https://doi.org/10.1016/j.yebeh.2008.07.009
• 20.Xu Y, Hackett ML, Nikpour A, Somerville E, Bleasel A, Ireland C, et al. Course and impact of sleep disturbance in newly diagnosed epilepsy: A prospective registry study. Clin Neurol Neurosurg. 2020;195:105963. https://doi.org/10.1016/j.clineuro.2020.105963
• 21.Maganti R, Sheth RD, Hermann BP, Weber S, Gidal BE, Fine J. Sleep architecture in children with idiopathic generalized epilepsy. Epilepsia. 2005;46(1):104-9. https://doi.org/10.1111/j.0013-9580.2005.06804.x
• 22.Parrino L, De Paolis F, Milioli G, Gioi G, Grassi A, Riccardi S, et al. Distinctive polysomnographic traits in nocturnal frontal lobe epilepsy. Epilepsia. 2012;53(7):1178-84. https://doi.org/10.1111/j.1528-1167.2012.03502.x
• 23.Crespel A, Coubes P, Baldy-Moulinier M. Sleep influence on seizures and epilepsy effects on sleep in partial frontal and temporal lobe epilepsies. Clin Neurophysiol. 2000;111 Suppl 2:S54-9. https://doi.org/10.1016/S1388-2457(00)00402-8
• 24.Vignatelli L, Bisulli F, Naldi I, Ferioli S, Pittau F, Provini F, et al. Excessive daytime sleepiness and subjective sleep quality in patients with nocturnal frontal lobe epilepsy: a case-control study. Epilepsia. 2006;47 Suppl 5:73-7. https://doi.org/10.1111/j.1528-1167.2006.00882.x
• 25.Malow BA, Levy K, Maturen K, Bowes R. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology. 2000;55(7):1002-7. https://doi.org/10.1212/WNL.55.7.1002