Serum Soluble Urokinase Plasminogen Activator Receptor as a Prognostic Biomarker in Children with Chronic Kidney Disease Due to Congenital Anomalies of the Kidney and Urinary System

Year 2025, Volume: 8 Issue: 3, 271 - 275, 30.09.2025

Aylin Gençler , Seyhan Taşkın

Abstract

Introduction: This study aimed to evaluate the relationship between serum soluble urokinase plasminogen activator receptor (suPAR) levels and chronic kidney disease (CKD) stages in children with CAKUT, the leading cause of pediatric CKD.
Metarials and Methods: Forty-two children with CAKUT-related CKD and 42 healthy controls were prospectively enrolled. Serum suPAR levels, estimated glomerular filtration rate (eGFR), and other laboratory parameters were compared. ROC analysis was used to assess the diagnostic performance of suPAR.
Results: suPAR levels were significantly higher in the patient group (p<0.001) and increased with CKD severity. A suPAR cut-off of ≥3.38 ng/mL predicted CKD with 85.7% sensitivity and 78.6% specificity. suPAR showed a negative correlation with eGFR and a positive correlation with creatinine and potassium levels.
Conclusion: Elevated suPAR levels may reflect CKD progression in children with CAKUT and serve as a non-invasive biomarker for early detection and disease monitoring.

Keywords

Soluble Urokinase Plasminogen Activator Receptor (suPAR) , Chronic Kidney Disease (CKD) , Congenital Kidney and Urinary System Anomalies (CAKUT) , Child , Estimated Glomerular Filtration Rate (eGFR)

Konjenital Böbrek ve Üriner Sistem Anomalilerine bağlı Kronik Böbrek Hastalığı olan Çocuklarda Prognostik Biyobelirteç olarak Serum Çözünür Ürokinaz Plazminojen Aktivatör Reseptörü

Abstract

Giriş: Bu çalışmanın amacı, çocuklarda kronik böbrek hastalığının (KBH) en yaygın nedeni olan konjenital böbrek ve üriner sistem anomalileri (CAKUT) bulunan çocuklarda serum suPAR düzeyleri ile KBH evreleri arasındaki ilişkiyi değerlendirmektir.
Gereç ve Yöntem: CAKUT kaynaklı KBH tanısı alan 42 çocuk hasta ve 42 sağlıklı kontrol prospektif olarak çalışmaya dahil edildi. Serum suPAR düzeyleri, tahmini glomerüler filtrasyon hızı (eGFR) ve diğer laboratuvar parametreleri karşılaştırıldı. suPAR’ın tanısal değerini belirlemek amacıyla ROC analizi yapıldı.
Sonuç: suPAR düzeyleri hasta grubunda anlamlı olarak yüksekti (p<0,001) ve KBH evresi ilerledikçe arttı. 3,38 ng/mL ve üzeri suPAR değerleri, KBH tanısını %85,7 duyarlılık ve %78,6 özgüllük ile öngördü. suPAR ile eGFR arasında negatif, kreatinin ve potasyum düzeyleri ile pozitif korelasyon saptandı.
Tartışma: Yükselmiş suPAR düzeyleri, CAKUT’a bağlı KBH ilerlemesini yansıtabilir ve bu biyobelirteç, hastalığın erken tanısı ve takibinde kullanılabilecek non-invaziv bir yöntem olabilir.

Keywords

Çözünür Ürokinaz Plazminojen Aktivatör Reseptörü (suPAR) , Kronik Böbrek Hastalığı (KBH) , Konjenital Böbrek ve Üriner Sistem Anomalileri (CAKUT) , Çocuk , Tahmini Glomerüler Filtrasyon Hızı (eGFR)

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